Application of Logistic Regression and Decision Tree Model in Prediction of Adverse Reactions of Iodinated Contrast Medium

Wenxiu XU; Xiaofeng MO; Xiangmin YANG; Silu YANG; Fan WU; Te LI

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Wenxiu XU, Xiaofeng MO, Xiangmin YANG, Silu YANG, Fan WU, Te LI. Application of Logistic Regression and Decision Tree Model in Prediction of Adverse Reactions of Iodinated Contrast Medium[J]. Journal of Kunming Medical University.

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Application of Logistic Regression and Decision Tree Model in Prediction of Adverse Reactions of Iodinated Contrast Medium

Wenxiu XU¹,
Xiaofeng MO¹,
Xiangmin YANG²,
Silu YANG¹,
Fan WU^{1
,
,},
Te LI^{1
,
,}

1.
Dept. of Pharmacy，Fuwai Yunnan Hospital，Chinese Academy of Medical Sciences，Kunming Yunnan 650102
2.
School of Pharmaceutical Sciences，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-12-05
Available Online: 2024-03-06

Abstract

Abstract

Objective Logistic regression and decision tree model were used to analyze the influencing factors of adverse reactions of iodine contrast agents and to provide guidance for clinical safe drug use. Methods The adverse reaction group consisted of 129 patients who underwent CT examination using ICM and had adverse reactions from January 2019 to August 2023 in Fuwai Yunnan Hospital. The control group consisted of 135 patients who did not have adverse reactions during the same period using ICM. The variables with statistical significance in the univariate analysis were incorporated into multi-factor Logistic regression and decision tree model to extract and analyze the influencing factors causing adverse reactions. Results Logistic regression showed that BMI, allergic history, and renal insufficiency were the influencing factors of ICM （P < 0.05）. The prediction model was: Lggit （P） = 0.123×BMI+1.684×allergy history + 2.551×renal insufficiency −3.652. Decision tree analysis screened out three risk variables, including allergy history, renal insufficiency and ICM type, among which allergy history was the most important influencing factor. Conclusion Logistic regression and the decision tree model can predict the influencing factors of adverse reactions and transform the study into an active prediction to avoid adverse reactions, it has reference value for the safe drug use of patients.
- Iodinated contrast medium,
- Adverse reactions,
- Logistic regression,
- Decision tree model

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References(24)

References

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