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Zhixin NIU, Lihua TANG, Lei SHI, Chao HONG, Yufeng YAO, Zhiling YAN. Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population[J]. Journal of Kunming Medical University.
Citation: Zhixin NIU, Lihua TANG, Lei SHI, Chao HONG, Yufeng YAO, Zhiling YAN. Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population[J]. Journal of Kunming Medical University.
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Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population

  • 1.

    Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118

  • 2.

    Dept. of Gynecology，The 1st People’s Hospital of Yuanmou County，Yuanmou Yunnan 651300

  • 3.

    Dept. of Gynecology，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

  • Received Date: 2024-01-16
    Available Online: 2024-04-29
    Abstract
  •   Objective  NRAS and MAPK1 genes are important regulators of the Ras/Raf/MEK/ERK signaling pathway, and their functions and expression levels have been associated with a variety of human tumors. This study aims to investigate the correlation between the rs14804 and rs9340 polymorphic loci of NRAS and MAPK1 genes and the susceptibility to cervical intraepithelial neoplasia （CIN） in Yunnan Han population.   Methods  1399 persons of the population were enrolled in the current study, with 416 as the CIN patient group and 983 as the healthy control group. The SNPs loci （rs14804 and rs9340） in the NRAS gene and the MAPK1 gene were genotyped using the TaqMan assays, and the correlation between the two SNPs loci and the risk of CIN was analyzed.   Results  The difference in the frequency of distribution of SNP locus rs9340 allele （P = 0.008） and genotype （P = 0.002） of MAPK1 gene in the CIN group versus the control group was statistically significant, and allele A may be associated with a higher risk of developing CIN （OR = 1.28, 95%CI 1.07 ～ 1.54）, especially for people in the lower age group （≤ 50 years） of CIN risk （OR = 1.35, 95%CI 1.09 ～ 1.67）.   Conclusion  rs9340 in the MAPK1 gene might be correlated with the risk of CIN in the Chinese Han population in Yunnan.
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  • [1]
    Bruni L A G,Serrano B,Mena M,et al. Human papillomavirus and related diseases in the world [R]. Barcelona,Spain,2023: ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre),Summary Report 22 October 2021.
    [2]
    冯明月,闫萍. 宫颈上皮内瘤变诊治现状[J]. 河北医科大学学报,2020,41(4):480-483.
    [3]
    Schiffman M, Castle P E, Jeronimo J, et al. Human papillomavirus and cervical cancer[J]. Lancet (London, England),2007,370(9590):890-907.
    [4]
    Chen D,Cui T,Ek W E,et al. Analysis of the genetic architecture of susceptibility to cervical cancer indicates that common SNPs explain a large proportion of the heritability[J]. Carcinogenesis,2015,36(9):992-998. doi: 10.1093/carcin/bgv083
    [5]
    Vink J M,Van Kemenade F J,Meijer C J,et al. Cervix smear abnormalities: Linking pathology data in female twins,their mothers and sisters [J]. European Journal of Human Genetics : EJHG,2011,19(1): 108-111.
    [6]
    Zhang X,Zhang L,Tian C,et al. Genetic variants and risk of cervical cancer: Epidemiological evidence,meta-analysis and research review[J]. BJOG,2014,121(6):664-674. doi: 10.1111/1471-0528.12638
    [7]
    Hatzivassiliou G,Song K,Yen I,et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth[J]. Nature,2010,464(7287):431-435. doi: 10.1038/nature08833
    [8]
    Yuan J,Dong X,Yap J,et al. The MAPK and AMPK signalings: Interplay and implication in targeted cancer therapy[J]. Journal of Hematology & Oncology,2020,13(1):113.
    [9]
    Xie G,Zhu A,Gu X. Mitogen-activated protein kinase inhibition-induced modulation of epidermal growth factor receptor signaling in human head and neck squamous cell carcinoma[J]. Head & Neck,2021,43(6):1721-1729.
    [10]
    Zhou G,Yang J,Song P. Correlation of ERK/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells[J]. Oncology Letters,2019,17(2):2266-2270.
    [11]
    Bartholomeusz C,Gonzalez-Angulo A M,Liu P,et al. High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients[J]. The Oncologist,2012,17(6):766-774. doi: 10.1634/theoncologist.2011-0377
    [12]
    Rauen K A. Defining RASopathy[J]. Dis Model Mech,2022,15(2):dmm049344. doi: 10.1242/dmm.049344
    [13]
    Yan Y,Gao Z,Han H,et al. NRAS expression is associated with prognosis and tumor immune microenvironment in lung adenocarcinoma[J]. J Cancer Res Clin Oncol,2022,148(3):565-575. doi: 10.1007/s00432-021-03842-w
    [14]
    Wang Y,Guo Z,Tian Y,et al. MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor[J]. BMC Cancer,2023,23(1):959. doi: 10.1186/s12885-023-11480-3
    [15]
    Harada G,Yang S R,Cocco E,et al. Rare molecular subtypes of lung cancer[J]. Nature Reviews Clinical Oncology,2023,20(4):229-249. doi: 10.1038/s41571-023-00733-6
    [16]
    Cicenas J,Tamosaitis L,Kvederaviciute K,et al. KRAS,NRAS and BRAF mutations in colorectal cancer and melanoma[J]. Medical Oncology (Northwood,London,England),2017,34(2):26. doi: 10.1007/s12032-016-0879-9
    [17]
    Ekedahl H, Cirenajwis H, Harbst K, et al. The clinical significance of BRAF and NRAS mutations in a clinic-based metastatic melanoma cohort[J]. Br J Dermatol,2013,169(5):1049-1055.
    [18]
    Emrick M A,Hoofnagle A N,Miller A S,et al. Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations[J]. The Journal of Biological Chemistry,2001,276(49):46469-46479. doi: 10.1074/jbc.M107708200
    [19]
    Ojesina A I,Lichtenstein L,Freeman S S,et al. Landscape of genomic alterations in cervical carcinomas[J]. Nature,2014,506(7488):371-375. doi: 10.1038/nature12881
    [20]
    Insodaite R,Smalinskiene A,Liutkevicius V,et al. Associations of polymorphisms localized in the 3'UTR regions of the KRAS,NRAS,MAPK1 genes with laryngeal squamous cell carcinoma[J]. Genes,2021,12(11):1679. doi: 10.3390/genes12111679
    [21]
    国家癌症中心,国家肿瘤质控中心宫颈癌质控专家委员会. 中国宫颈癌规范诊疗质量控制指标(2022版)[J]. 中华肿瘤杂志,2022,44(7):615-622.
    [22]
    中华人民共和国国家卫生和计划生育委员会. 宫颈癌及癌前病变规范化诊疗指南(试行)[J]. 中国医学前沿杂志(电子版),2013,5(8):40-49.
    [23]
    Bhatla N,Aoki D,Sharma D N,et al. Cancer of the cervix uteri[J]. International Journal of Gynecology & amp; Obstetrics,2018,143(S2):22-36.
    [24]
    中华医学会妇产科学分会绝经学组. 中国绝经管理与绝经激素治疗指南2023版[J]. 中华妇产科杂志,2023,58(1):4-21.
    [25]
    Ma H,Tian T,Liu X,et al. Upregulated circ_0005576 facilitates cervical cancer progression via the miR-153/KIF20A axis[J]. Biomed Pharmacother,2019(10):109311. doi: 10.1016/j.biopha.2019.109311
    [26]
    Shao M X,Qu A Z,Wang Y Q,et al. Expression level of miRNA-210-3p in cervical cancer and its prognostic potential[J]. Eur Rev Med Pharmacol Sci,2020,24(12):6583-6588.
    [27]
    Bos J L. The ras gene family and human carcinogenesis[J]. Mutation Research,1988,195(3):255-271. doi: 10.1016/0165-1110(88)90004-8
    [28]
    Guin S,Theodorescu D. The RAS-RAL axis in cancer: Evidence for mutation-specific selectivity in non-small cell lung cancer[J]. Acta Pharmacologica Sinica,2015,36(3):291-297. doi: 10.1038/aps.2014.129
    [29]
    Lanfredini S,Thapa A,O'neill E. RAS in pancreatic cancer[J]. Biochemical Society Transactions,2019,47(4):961-972. doi: 10.1042/BST20170521
    [30]
    Afrăsânie V A,Marinca M V,Alexa-Stratulat T,et al. KRAS,NRAS,BRAF,HER2 and microsatellite instability in metastatic colorectal cancer - practical implications for the clinician[J]. Radiology and Oncology,2019,53(3):265-274. doi: 10.2478/raon-2019-0033
    [31]
    Li S,Balmain A,Counter C M. A model for RAS mutation patterns in cancers: Finding the sweet spot[J]. Nature Reviews Cancer,2018,18(12):767-777. doi: 10.1038/s41568-018-0076-6
    [32]
    Jakob J A,Bassett R L J r,Ng C S,et al. NRAS mutation status is an independent prognostic factor in metastatic melanoma[J]. Cancer,2012,118(16):4014-4023. doi: 10.1002/cncr.26724
    [33]
    Schirripa M,Cremolini C,Loupakis F,et al. Role of NRAS mutations as prognostic and predictive markers in metastatic colorectal cancer[J]. International Journal of Cancer,2015,136(1):83-90. doi: 10.1002/ijc.28955
    [34]
    Murphy B M, Terrell E M, Chirasani V R, et al. Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation[J]. Nat Commun,2022,13(1):3153.
    [35]
    Fu W,Zhuo Z,Hua R X,et al. Association of KRAS and NRAS gene polymorphisms with Wilms tumor risk: A four-center case-control study[J]. Aging,2019,11(5):1551-1563. doi: 10.18632/aging.101855
    [36]
    Alessandro L,Low K E,Abushelaibi A,et al. Identification of NRAS diagnostic biomarkers and drug targets for endometrial cancer-an integrated in silico approach[J]. International Journal of Molecular Sciences,2022,23(22):14285. doi: 10.3390/ijms232214285
    [37]
    Jin M,Li Z,Sun Y,et al. Association analysis between the interaction of RAS family genes mutations and papillary thyroid carcinoma in the Han Chinese population[J]. International Journal of Medical Sciences,2021,18(2):441-447. doi: 10.7150/ijms.50026
    [38]
    Li S,Ma Y M,Zheng P S,et al. GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2 [J]. Journal of Experimental & Clinical Cancer Research : CR,2018,37(1): 80.
    [39]
    Yan Z,Ohuchida K,Fei S,et al. Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis [J]. Journal of Experimental & Clinical Cancer Research : CR,2019,38(1): 221.
    [40]
    Deng R,Zhang H L,Huang J H,et al. MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis[J]. Autophagy,2021,17(10):3011-3029. doi: 10.1080/15548627.2020.1850609
    [41]
    Wills C, Watts K, Maughan TS, et al. Germline variation in RASAL2 may predict survival in patients with RAS-activated colorectal cancer[J]. Genes Chromosomes Cancer,2023,62(6):332-341.
    [42]
    Campbell J D,Alexandrov A,Kim J,et al. Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas[J]. Nature Genetics,2016,48(6):607-616. doi: 10.1038/ng.3564
    [43]
    Santos M,Lima L,Carvalho S,et al. The impact of BDNF,NTRK2,NGFR,CREB1,GSK3B,AKT,MAPK1,MTOR,PTEN,ARC,and SYN1 genetic polymorphisms in antidepressant treatment response phenotypes[J]. International Journal of Molecular Sciences,2023,24(7):6758. doi: 10.3390/ijms24076758
    [44]
    Zhu Y, Yang T, Duan J, et al. MALAT1/miR-15b-5p/MAPK1 mediates endothelial progenitor cells autophagy and affects coronary atherosclerotic heart disease via mTOR signaling pathway[J]. Aging,2019,11(4):1089-109.
    [45]
    Guney G,Taşkın M I,Sener N,et al. The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis [J]. Reproductive Biology and Endocrinology : RB&E,2022,20(1): 95.
    [46]
    Wei H,Ke H L,Lin J,et al. MicroRNA target site polymorphisms in the VHL-HIF1α pathway predict renal cell carcinoma risk[J]. Molecular Carcinogenesis,2014,53(1):1-7. doi: 10.1002/mc.21917
    [47]
    Guo N,Zhang N,Yan L,et al. Correlation between genetic polymorphisms within the MAPK1/HIF-1/HO-1 signaling pathway and risk or prognosis of perimenopausal coronary artery disease[J]. Clinical Cardiology,2017,40(8):597-604. doi: 10.1002/clc.22708
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