A Two-Sample Mendelian Randomization Study of Nut Intake and Primary Lung Cancer

Xueyun GUO; Zheng HUANG; Na LI; Guozhong TAO

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 >

Xueyun GUO, Zheng HUANG, Na LI, Guozhong TAO. A Two-Sample Mendelian Randomization Study of Nut Intake and Primary Lung Cancer[J]. Journal of Kunming Medical University.

Citation:

Xueyun GUO, Zheng HUANG, Na LI, Guozhong TAO. A Two-Sample Mendelian Randomization Study of Nut Intake and Primary Lung Cancer[J]. Journal of Kunming Medical University.

Xueyun GUO, Zheng HUANG, Na LI, Guozhong TAO. A Two-Sample Mendelian Randomization Study of Nut Intake and Primary Lung Cancer[J]. Journal of Kunming Medical University.

Citation:

Xueyun GUO, Zheng HUANG, Na LI, Guozhong TAO. A Two-Sample Mendelian Randomization Study of Nut Intake and Primary Lung Cancer[J]. Journal of Kunming Medical University.

PDF( 2327 KB)

A Two-Sample Mendelian Randomization Study of Nut Intake and Primary Lung Cancer

1.
Oncology Department of Tianchang People’s Hospital
2.
Dep. of Infectious Diseases Tianchang Anhui 239321，China

Received Date: 2024-03-10
Available Online: 2024-05-11

Abstract

Abstract

Objective To investigate the potential causal relationship between nut consumption and primary lung cancer by two-sample Mendelian randomization method. Methods Single nucleotide polymorp hisms （P < 5×10^-7） associated with nut intake were screened from the openGWAS public database of genome - wide association study as instrumental variables. The inverse variance weighting method was the main analysis method to evaluate the causal effect of this study, and MR-Egger regression and weighted median method were used to supplement the explanation. OR value and 95%CI were used to evaluate whether there was a causal relationship between nut intake and primary lung cancer. The mr_pleiotropy_test and MR-PRESSO were used to test the level pleiotropy, and the leave-one-out method was used to test the sensitivity. Results A total of 100 SNPs were extracted from the ukb-b-16576 dataset as instrumental variables. The MR-Egger regression, weighted median, and inverse variance weighting methods yielded OR values and 95% confidence intervals [0.63, 95%CI （0.11-3.65）, P = 0.611], [0.34, 95%CI （0.19-0.61）, P = 0.001], [0.32, 95%CI （0.21-0.48）, P = 0.001], rerespectively. The mr_pleiotropy_test showed that the MR-Egger intercept was close to 0 （-7.66E-03） with a p-value of 0.441, indicating no significant horizontal pleiotropy. Similarly, the MR-PRESSO package GlobalTest yielded a p-value of 0.162, further confirming the absence of horizontal pleiotropy among the selected instrumental variables.After conducting the leave-one-out sensitivity analysis, no significant influence on the results was observed from any specific SNP locus, indicating that the results are highly stable and reliable. Conclusions The two-sample Mendelian randomization analysis revealed a negative causal relationship between nut intake and the risk of primary lung cancer. However, further verification is needed with larger sample sizes and data from individuals of different ethnic backgrounds to strengthen the findings.
- Nuts,
- Primary lung cancer,
- Mendel randomization,
- Causal inference

FullText(HTML)

References(20)

References

[1]	Sung H,Ferlay J,Siegel R L,et al. Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2021,71(3):209-249. doi: 10.3322/caac.21660
[2]	Xia C,Dong X,Li H,et al. Cancer statistics in China and United States,2022: Profiles,trends,anddeterminants[J]. Chin Med J (Engl),2022,135(5):584-590. doi: 10.1097/CM9.0000000000002108
[3]	Chen S,Cao Z,Prettner K,et al. Estimates and projections of the global economic cost of 29 cancers in 204 countries and territories from 2020 to 2050[J]. JAMA Oncol,2023,9(4):465-472. doi: 10.1001/jamaoncol.2022.7826
[4]	开比努尔·再比布力,姑丽切克然·艾斯克,韩加. 坚果营养成分及保健功效的研究[J]. 粮食与食品工业,2022,29(3):32-36. doi: 10.3969/j.issn.1672-5026.2022.03.009
[5]	Chang C,Xinyan G,Yan H,et al. Association between nut consumption and cancer risk: A meta-analysis[J]. Nutrition and cancer,2022,75(1):11-13.
[6]	Nieuwenhuis L,van den Brandt P A. Nut and peanut butter consumption and the risk of lung cancer and its subtypes: A prospective cohort study[J]. Lung Cancer,2019,128(1):57-66.
[7]	Hemani G,Zheng J,Elsworth B,et al. The MR-Base platform supports systematic causal inferenceacross the human phenome[J]. Elife,2018,7(1):e34408.
[8]	Rasooly D,Patel C J. Conducting a reproducible mendelian randomization analysis using the R analytic statistical environment.[J]. Current protocols in human genetics,2019,101(1):82. doi: 10.1002/cphg.82
[9]	Paraskevas A,Bellou E ,Keramida E,et al. Bronchial asthma and lung cancer[J]. Current Respira tory Medicine Reviews,2021,17(2): 78-82.
[10]	Forder A,Zhuang R,Souza V,et al. Mechanisms contributing to the comorbidity of COPD and lung cancer[J]. Int J Mol Sci,2023,24(3):2859-2861. doi: 10.3390/ijms24032859
[11]	Fu R,Kim S J. Inferring causality from observational studies: the role of instrumental variable ana lysis[J]. Kidney Int,2021,99(6):1303-1308. doi: 10.1016/j.kint.2021.03.018
[12]	Wang X,Jiang Y,Zhang N R,et al. Sensitivity analysis and power for instrumental variable studi es[J]. Biometrics,2018,74(4):1150-1160. doi: 10.1111/biom.12873
[13]	周启武,唐兴莹,李志宏,等. 5种市售坚果类产品部分营养成分及重金属元素分析[J]. 安徽农业科学,2022,50(19):193-197.
[14]	Luu H N,Cai H,Murff H J,et al. A prospective study of dietary polyunsaturated fatty acids int ke and lung cancer risk[J]. Int J Cancer,2018,143(9):2225-2237. doi: 10.1002/ijc.31608
[15]	Yang J J,Yu D,Takata Y,et al. Dietary Fat intake and lung cancer risk: A pooled analysis[J]. J Clin Oncol,2017,35(26):3055-3064. doi: 10.1200/JCO.2017.73.3329
[16]	Bai Y,Wang G,Fu W,et al. Circulating essential metals and lung cancer: risk assessment and p tential molecular effects[J]. Environ Int,2019,127:685-693. doi: 10.1016/j.envint.2019.04.021
[17]	李晓阳,吴志平,王梦馨,等. 表没食子儿茶素没食子酸酯抗癌分子机制及其应用的研究进展[J]. 草药,2019,50(13):3217-3229.
[18]	Zanoaga O,Braicu C,Jurj A,et al. Progress in research on the role of flavonoids in lung can cer[J]. Int J Mol Sci,2019,20(17):4291-4293. doi: 10.3390/ijms20174291
[19]	RBB,L R S ,Ashkan E. Discussion on instrumental variable estimation of the causal hazard ratio[J]. Biometrics,2023,79(2): 554-558.
[20]	Fei W,Dylan S,Nandita M. A general approach to evaluating the bias of 2-stage instrumental var iable estimators[J]. Statistics in medicine,2018,37(12):1997-2015. doi: 10.1002/sim.7636

Relative Articles(20)

Relative Articles

[1]	Wu Ke . Clinical Observation of Video Assisted Thoracic Surgery For Primary Non Small Cell Lung Cancer. Journal of Kunming Medical University,
[2]	Wang Yan Ping . . Journal of Kunming Medical University,
[3]	Gao Hong . . Journal of Kunming Medical University,
[4]	Hao Jian Cheng . . Journal of Kunming Medical University,
[5]	Yang Jing . . Journal of Kunming Medical University,
[6]	Huang Xing Zhi . . Journal of Kunming Medical University,
[7]	Wu Jian . . Journal of Kunming Medical University,
[8]	Yang Ying . . Journal of Kunming Medical University,
[9]	Lu Jing . . Journal of Kunming Medical University,
[10]	Lu Jian Fei . . Journal of Kunming Medical University,
[11]	Han Fang Qi . . Journal of Kunming Medical University,
[12]	Guo Xue Song . . Journal of Kunming Medical University,
[13]	Lai Wei . The Analysis of Endoscopic Ultrasonography Characteristics in Patients with Primary Sclerosing Cholangitis. Journal of Kunming Medical University,
[14]	Zhang Jie . . Journal of Kunming Medical University,
[15]	Xu Yang . . Journal of Kunming Medical University,
[16]	. Investigation on the Levels of Blood Glucose in 464 Hospitalized Non-diabetic Patients with Essential Hypertension. Journal of Kunming Medical University,
[17]	Zhang Hong Qing . . Journal of Kunming Medical University,
[18]	. . Journal of Kunming Medical University,
[19]	Dong Ming Lin . . Journal of Kunming Medical University,
[20]	Hao Jin Gang . . Journal of Kunming Medical University,