Correlations between CD4<sup>+</sup>CD25<sup>+</sup>Treg，sCD30 and Clinical Characteristics of Lymphoma and Their Value in Predicting Infection after Chemotherapy

Chunyan LIU; Bingqing CHANG; Chao LI; Xin REN; Xiaoqin LIU

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 >

Chunyan LIU, Bingqing CHANG, Chao LI, Xin REN, Xiaoqin LIU. Correlations between CD4+CD25+Treg，sCD30 and Clinical Characteristics of Lymphoma and Their Value in Predicting Infection after Chemotherapy[J]. Journal of Kunming Medical University.

Citation:

Chunyan LIU, Bingqing CHANG, Chao LI, Xin REN, Xiaoqin LIU. Correlations between CD4⁺CD25⁺Treg，sCD30 and Clinical Characteristics of Lymphoma and Their Value in Predicting Infection after Chemotherapy[J]. Journal of Kunming Medical University.

Citation:

PDF( 706 KB)

Correlations between CD4⁺CD25⁺Treg，sCD30 and Clinical Characteristics of Lymphoma and Their Value in Predicting Infection after Chemotherapy

Dept. of Hematology，Beijing Aerospace General Hospital，Beijing 100076，China

More Information

Corresponding author: 刘小琴，E-mail：youzi520521@163.com
Received Date: 2023-12-31
Available Online: 2024-04-02

Abstract

Abstract

Objective To investigate the expression and significance of CD4⁺CD25⁺ regulatory T cells （CD4⁺CD25⁺Treg） and soluble CD30 （sCD30） in peripheral blood of lymphoma patients. Methods A total of 83 lymphoma patients admitted to Beijing Aerospace General Hospital from January 2018 to December 2022 were selected as the research subjects, and their peripheral blood CD4⁺CD25⁺Treg and sCD30 expressions were statistically analyzed. Spearman analysis was used to investigate the correlation between peripheral blood CD4⁺CD25⁺Treg and sCD30 expressions and bone marrow infiltration. At the same time, the research subjects were divided into an infection group （n = 26） and a non-infection group （n = 57） according to the presence or absence of infection after rituximab chemotherapy. The expressions and differences of peripheral blood CD4⁺CD25⁺Treg and sCD30 in the two groups were compared, and the receiver operating characteristic （ROC） curve and area under the curve （AUC） were used to analyze the predictive efficacy. Results The expression of CD4⁺CD25⁺Treg and sCD30 in peripheral blood of patients with bone marrow infiltration was higher than that of patients without bone marrow infiltration in the research group （P < 0.05）; the expression of CD4⁺CD25⁺Treg and sCD30 in peripheral blood of lymphoma patients was positively correlated with bone marrow infiltration （r = 0.612, 0.634, P < 0.05）; the expression of Tregs and sCD30 in peripheral blood of the infection group after chemotherapy was higher than that of the non-infection group, and the difference was higher than that of the non-infection group （P < 0.05）; the ROC curve showed that the combined prediction of the difference of CD4⁺CD25⁺Treg and sCD30 in peripheral blood for the infection after chemotherapy in lymphoma patients had an AUC of 0.916 （0.834-0.965）, which was superior to single prediction. Conclusion The high expression of CD4⁺CD25⁺Treg and sCD30 in peripheral blood of lymphoma patients is positively correlated with bone marrow infiltration. Combined testing can improve the predictive efficacy of infection after chemotherapy and guide clinical diagnosis and treatment.
- Lymphoma,
- Bone marrow infiltration,
- Chemotherapy,
- Infection,
- CD4⁺CD25⁺Treg,
- sCD30

FullText(HTML)

References(23)

References

[1]	Olsen E A,Whittaker S,Willemze R,et al. Primary cutaneous lymphoma: Recommendations for clinical trial design and staging update from the ISCL,USCLC,and EORTC[J]. Blood,2022,140(5):419-437. doi: 10.1182/blood.2021012057
[2]	De Roos A J,Fritschi L,Ward M H,et al. Herbicide use in farming and other jobs in relation to non-Hodgkin's lymphoma (NHL) risk[J]. Occup Environ Med,2022,79(12):795-806. doi: 10.1136/oemed-2022-108371
[3]	李巧,王珂. 利妥昔单抗联合CHOP方案治疗弥漫大B细胞淋巴瘤的疗效观察[J]. 中国肿瘤临床与康复,2021,28(10):1162-1164.
[4]	包仁君,徐选福,莫文辉,等. 非霍奇金淋巴瘤患者R-CHOP 化疗后肝损伤的易感因素及异甘草酸镁预防性保肝作用研究[J]. 世界临床药物,2022,43(10):1362-1368.
[5]	Grygorowicz M A,Borycka I S,Nowak E,et al. Lenalidomide potentiates cd4+cd25+treg-related suppression of lymphoma B-cell proliferation[J]. Clin Exp Med,2017,17(2):193-207. doi: 10.1007/s10238-016-0411-8
[6]	Rhee J,Birmann B M,De Roos A J,et al. Circulating immune markers and risks of non-Hodgkin lymphoma subtypes: A pooled analysis[J]. Int J Cancer,2023,152(5):865-878. doi: 10.1002/ijc.34299
[7]	中国抗癌协会淋巴瘤专业委员会,中国医师协会肿瘤医师分会,中国医疗保健国际交流促进会肿瘤内科分会,等. 中国淋巴瘤治疗指南(2021年版)[J]. 中华肿瘤杂志,2021,43(7):707-735.
[8]	刘蕾,易琴,聂甜,等. NHL化疗患者NLR,PLR,RDW变化及对肺部感染的预测价值[J]. 分子诊断与治疗杂志,2021,13(11):1800-1804.
[9]	Wang Y,Liu X,Yan P,et al. Association between type 1 and type 2 diabetes and risk of non-Hodgkin's lymphoma: A meta-analysis of cohort studies[J]. Diabetes Metab,2020,46(1):8-19. doi: 10.1016/j.diabet.2019.04.006
[10]	Gerlach M M,Juskevicius D,Vela V,et al. Bone marrow infiltration of angioimmunoblastic T-cell lymphoma: Identification and prognostic impact of histologic patterns and diagnostic application of ancillary phenotypic and molecular analyses[J]. Arch Pathol Lab Med,2020,144(5):602-611. doi: 10.5858/arpa.2019-0007-OA
[11]	Alonso-Álvarez S,Alcoceba M,García-Álvarez M,et al. Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma[J]. Cancers (Basel),2020,12(2):474. doi: 10.3390/cancers12020474
[12]	陈香,乔文礼,宋建华,等. 继发性骨淋巴瘤的^(18)F-FDG PET/CT影像诊断及与骨髓活检诊断效能的比较[J]. 现代肿瘤医学,2021,29(14):6.
[13]	Shin H J,Kim D Y,Chung J,et al. Prognostic impact of peripheral blood T-cell subsets at the time of diagnosis on survival in patients with diffuse large B-cell lymphoma[J]. Acta Haematol,2021,144(4):427-437. doi: 10.1159/000510912
[14]	Liu B C,Wei C Y. Hypoxia induces overexpression of ccl28 to recruit treg cells to enhance angiogenesis in lung adenocarcinoma[J]. J Environ Pathol Toxicol Oncol,2021,40(1):65-74. doi: 10.1615/JEnvironPatholToxicolOncol.2020035859
[15]	Wang W,Ye C H,Deng Z F,et al. Cd4+cd25+ regulatory T cells decreased future liver remnant after associating liver partition and portal vein ligation for staged hepatectomy[J]. World J Gastrointest Surg,2023,15(5):917-930. doi: 10.4240/wjgs.v15.i5.917
[16]	王欣,梁艳丽,李艳秋,等. 血清TK1和sCD30水平与T细胞淋巴瘤患者临床特征的相关性[J]. 海军医学杂志,2022,43(1):65-69.
[17]	Levin L I,Ramirez C M,Liao E L,et al. Longitudinal changes in immune activation serum biomarkers prior to diagnosis and risk of B-cell nhl subtypes[J]. Cancer Epidemiol Biomarkers Prev,2023,32(2):233-241. doi: 10.1158/1055-9965.EPI-22-0247
[18]	陈瑜,陶石,胡敏,等. 血清Flt3L和Gas6水平对非霍奇金淋巴瘤患者利妥昔单抗化疗后肺部感染预测价值分析[J]. 分子诊断与治疗杂志,2022,14(4):652-655,659.
[19]	Lee J,Lee R,Beck K S,et al. Migratory pneumonia in prolonged SARS-COV-2 infection in patients treated with B-cell depletion therapies for B-cell lymphoma[J]. Korean J Radiol,2023,24(4):362-370. doi: 10.3348/kjr.2022.0844
[20]	康从越,夏永寿,叶先梅,等. 淋巴瘤患者化疗后肺部感染病原学分析及免疫球蛋白变化[J]. 中国肿瘤临床与康复,2021,28(9):1111-1115.
[21]	李碧云,韩亚辉,殷楚云,等. 利妥昔单抗治疗儿童及青少年成熟B细胞非霍奇金淋巴瘤疗效及安全性的Meta分析[J]. 中国当代儿科杂志,2023,25(1):51-59.
[22]	谷振阳,王全顺,黄文荣,等. 程序性死亡因子-1抑制剂治疗合并中枢神经系统受累的复发/难治性弥漫大B细胞淋巴瘤患者的临床分析并文献复习[J]. 国际输血及血液学杂志,2021,44(4):336-342.
[23]	张艳彬,陈文昆,周寅,等. NLRP3炎性小体水平检测在非霍奇金淋巴瘤患者免疫治疗相关细胞因子风暴及化疗相关间质性肺炎中的预测价值分析[J]. 疑难病杂志,2022,21(5):485-491,506.

Relative Articles(20)

Relative Articles

[1]	Caini ZHANG, Ya LI. A Meta-analysis of the Efficacy and Safety of Camrelizumab Combined with Chemotherapy in the Treatment of Non-small Cell Lung Cancer. Journal of Kunming Medical University,
[2]	Shuangshuang WANG, Liqin CHEN, Yaling LI, Weijie LI, Jiayi YANG. Analysis of Epidemiological Characteristics of Neonatal Rotavirus Infection from 2020 to 2022. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230509
[3]	Xi LIU, Xin LIU, Jingjing CAI, Yaxi DU, Hongsheng LI, Yongchun ZHOU. Application of Nanopore Sequencing in Tumor with Infection. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230710
[4]	Jiang WU, Shuifen DAI, Qin LIU, Shoutao YANG, Jiang ZHANG, Jiao YANG, Qiongyao GUAN. Effect of Nutrition Clinical Nursing Pathway for Nasopharyngeal Carcinoma Patients Concurrent Radiotherapy and Chemotherapy. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230510
[5]	Shulan SHI, Lijuan QIU, Liyue KUI, Min SU, Bailing ZHOU, Rongjie LI, Jianming SUN. Diagnostic Value of Interleukin-6，Interleukin-10，High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230115
[6]	Jiawei LIAO, Xiaoqing HU, Yi YANG. Changes of Thyroid Function and Its Clinical Significance before and after Radiotherapy and Chemotherapy in Patients Undergoing Radical Breast Cancer Treatment. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220229
[7]	Tingting YU, Dongling LI, Hongying WANG, Lihua LI, Dong PU, Kunli WU. Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220133
[8]	Ling ZHOU, Feng-di HU, Rong LI, Ye-dan LIAO, Zheng-qin GENG, Jia-dai TANG, Xue-qi ZHANG, Lin XIE, Zuo-zhang YANG. A Clinical Scoring System Predicting the Osteosarcoma Chemotherapy Drug Resistance. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210144
[9]	Fu-Jun ZHANG, Rong GONG. Significance of Dynamic Monitoring of T Lymphocyte Subsets and NK Cells in Patients with Esophageal Cancer before and after the Surgery and Chemotherapy. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210935
[10]	Nie Bo . Clinical Characteristic of 34 Patients with Extranodal Nasal Type NK/T-Cell Lymphoma. Journal of Kunming Medical University,
[11]	Wang Yuan Yuan . . Journal of Kunming Medical University,
[12]	Yang Huan Zhi . . Journal of Kunming Medical University,
[13]	Song Jian Ling . . Journal of Kunming Medical University,
[14]	Wu Xue Song . . Journal of Kunming Medical University,
[15]	Liu Yi . . Journal of Kunming Medical University,
[16]	Wang Ruo Tian . . Journal of Kunming Medical University,
[17]	Li Chong Yang . . Journal of Kunming Medical University,
[18]	Chen Hong Bo . . Journal of Kunming Medical University,
[19]	Duan Xian Meng . . Journal of Kunming Medical University,
[20]	Yu Mei . . Journal of Kunming Medical University,