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Supervisor：Education Department of Yunnan Province Sponsor：Kunming Medical University Chief Editor：Xia Xueshan

ISSN 2095-610X CN 53-1221/R

Address：1168 Chunrong West Road, Yuhua street, Chenggong New City, Kunming

Postal Code：650500 Telephone：0871－65936489 

E-mail：kmykdxxbzk@163.com

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Articles just accepted have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
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Predictive Assessment of Delirium in Elderly Frail Patients Using FRAIL，CFS，and REFS Scales: Analysis of Risk Factors
Jia TAN, Yixing ZOU, Xiaoying HAN, Guangming DING, Zhaohui LENG
Abstract(10) PDF(0)
Effects of Sanqi Oral Liquid on Glycolysis，Renal Cell Apoptosis，and Keap1-Nrf2 Signaling Pathway in Diabetic Nephropathy Rats
Wenchao LI, Xue LI, Shanshan LIN, Yun MA, Guorui KANG, Ye CHEN
Abstract(8) PDF(0)
Concordance and Correlation Analysis of Mismatch Repair and Microsatellite Status in 412 Cases of Colorectal Cancer in Yunnan Province
Anmin WANG, Zhongfa LIU, Chunhui YANG, Guangsi ZOU, Chengmin SHI, Yujian ZENG
Abstract(43) PDF(4)
Clinical Study on Predicting Pregnancy Outcomes through The Imbalance of Vaginal Microbiota and Levels of Inflammatory Factors in Pregnant Women
Qing LI, Wei GENG, Fengxi ZHANG, Dan ZHANG
Abstract(278) PDF(84)
Mechanism of miR-21-5p in Promoting Osteoarthritis Progression Through Inhibition of the SIRT2/AKT Signaling Pathway
Xiaotian CHEN, Zhenfei DING, Yining SONG, Banghong JIANG, Fan ZHANG, Yi GAO, Jianzhong GUAN
Abstract(0) PDF(0)
Serum sCD276 and HE4 Levels in Ovarian Cancer Patients and Their Correlation with Postoperative Recurrence
Ruisheng XING, Hua LIU, Li GAO, Xiaobai FANG, Lei ZHAO
Abstract(8) PDF(0)
Effect of Lipid Metabolism-Related Genes ASP and PPARα in Atherosclerosis
Yating WANG, Wei XIE, Yaling GUAN, Dilihumar ABULAITI, Meng YE, Taotao JIA, Ying GAO
Abstract(5) PDF(0)
Inhibition of Breast Cancer by Ethanol Extract of Hedyotis diffusa through Mitochondrial Apoptosis Mediated by Cytochrome c/Caspase-9
Xiaoxiao LIAN, Tao HAN, Kunmeng CUI, Yan WANG, Yongfang LIU, Tian GUO, Ruixue YANG, Ya WANG
Abstract(8) PDF(0)
Mechanism on Glu/GABA Regulating Neurotransmitter Balance to Improve Behavioral Abnormalities in Rat Models of Tourette Syndrome
Jingjing DUAN, Ningyu DU, Yan XIAO, Xiang LIU, Junxia CUI
Abstract(12) PDF(0)
Activation of γ-Aminobutyric Acid Type A Receptor Attenuates Oxygen-Glucose Deprivation/Reoxygenation-Induced Astrocyte Injury
Hongxia HE, Tingting CHEN, Fei HUANG, Junwu LIU, Hongli ZHOU, Lei XU
Abstract(8) PDF(0)
Effects of Stem Cells on Myocardial Infarction Repair and Cardiac Electrophysiology Based on Exosomal STAT3 Protein Transport
Xiaoxia SHEN, Chunhui FENG, Xiaodong ZHAO
Abstract(9) PDF(0)
Novel Conservative Treatment Mechanisms and Clinical Translation for Female Stress Urinary Incontinence
Jing FU, Jianlin PU, Zhong LI, Qiuyue MAO, Chunlan LI, Xuesong GAI
Abstract(11) PDF(0)
Evaluative Value of Serum TNFSF14，TLR7，and sCD14-ST Levels in Assessing Disease Severity and Prognosis of Respiratory Syncytial Virus Infection-Related Pneumonia in Children
Xiaowei LI, Kai YANG, Fanrong WANG, Xu LIU
Abstract(8) PDF(0)
Diagnostic Value of Ultrasonography Combined with Serum IL-1β And CYFRA21-1 in Ovarian Cancer
Shuwei WANG, Yuli ZHANG, Heli LIU, Jie SU
Abstract(8) PDF(0)
Effects of p16 on the Cell Cycle and Fatty Acid Metabolism of Gallbladder Cancer Cells
Yongli MO, Xiaoping WEI, Henghai YU, Rui LIU
Abstract(16) PDF(0)
Efficacy of Multimodal Bronchoscopic Interventions for Benign Central Airway Stenosis and Prognostic Factors: A Retrospective Cohort Study
Chengjin LI, Rongrong WU, Guiping LIU, Jiefu TANG, Le WANG, Zhuang LUO
Abstract(0) PDF(0)
The Prognostic Value of Uterine Artery Blood Flow Combined with Serum Factors for Preeclampsia in Mid-pregnancy
Ruiyan LEI, Huimin HAO, Peiying WANG, Hui SUN, Li ZHANG
Abstract(31) PDF(0)
Mechanism of HDAC3-Targeted Regulation of GATA-2 Affecting Osteogenic Differentiation of Dental Pulp Stem Cells
Qian OUYANG, Yanfei HUANG, Lingyun YIN, Lingpeng ZHANG, Jing LIANG, Hongbin YU
Abstract(31) PDF(0)
The Effect of Microbial Metabolites on Immune Function Reconstruction of Aids Based on Mitochondrial Dysfunction
Mengtian XIA, Beilei LI, Qian CHEN, Xiafei JIN, Feng WEI, Kaixuan WANG
Abstract(28) PDF(0)
TMAO Inhibitors' Effects on Diabetic Sarcopenia in Rats
Shuimei LIAN, Qian YANG, Ting WANG
Abstract(31) PDF(0)
Efficacy of Sacubitril/Valsartan in the Treatment of Patients with Coronary Artery Disease Complicated by Heart Failure
Qianru XU, Songwu DONG, Rongyan Jiang
Abstract(38) PDF(1)
Study on the Mechanism of Trim47 in Acute Lung Injury via TAB1/I κB Inflammatory Signaling Pathway
Yunping OUYANG, Tao CHEN, Peng LI, Bo ZHAO, Xiaojun YANG
Abstract(25) PDF(0)
Expression of LMO2 and CAPRIN1 in Pancreatic Cancer Tissues and Their Correlation with Prognosis
Yuhua XIAO, Lingxin YAN, Jidong CAO, Jinhua CHAI
Abstract(39) PDF(0)
Construction of a Predictive Model for High-Risk ISS Stage in Newly Diagnosed Multiple Myeloma Patients Based on Coagulation Indicators
Ruicheng LI, Huarong JING, Yin WU, Ziqi LIN, Peipei ZHAO, Shan WEI, Tian WANG
Abstract(58) PDF(0)
Synergistic Mechanisms and Applications of Phage-Antibiotic Combination Therapy
Xuelin LI, Xiaoyan YANG, Zehua HAN, Yuliang CHEN, Xingyuan XU, Chunyan ZHANG, Yingying XIANG
Abstract(57) PDF(1)
Correlation between Serum IL-10，CTL and EB Virus Associated Infectious Mononucleosis Complicated with Liver Damage in Children
Weili LI, Danhua RU, Dan XIE, Jing ZHANG, Ya CHANG, Zhaoxin YANG
Abstract(37) PDF(0)
Relationship Between Latent Class of Frailty and Symptom Distress in Lung Cancer Radiotherapy Patients
Jiang WU, Xijuan ZHAO, Shoutao YANG, Yanyan FEI, Liping ZHOU, Jiang ZHANG
Abstract(34) PDF(1)
Empirical Analysis of the Three-Dimensional Structure of Clinical Reasoning Ability and Construction of Targeted Python Case Library from the Perspective of Cluster Analysis
Nana MENG, Lu SUN, Shenquan CHEN, Wenwen GUO, Haisi LIANG
Abstract(31) PDF(0)
Effects of Inhibiting lncRNA H19 Expression on Neuroinflammation and Cognitive Function in Vascular Dementia Models
Haixiao BAI, Huan WANG, Xinfei DUAN, Pingping FANG, Xiao LI, Jundong JIA
Abstract(45) PDF(1)
Clinical Efficacy of Short-term Spinal Cord Stimulation and Dorsal Root Ganglion Stimulation in the Treatment of Herpes Zoster-related Neuralgia and Improvement of Sleep Quality
Wenbiao HAN, Wenjuan HAN, Hongchen SHI, Liqin GAO, Xiaohui LIU, Junpeng LIU, Yunpeng MA
Abstract(35) PDF(2)
Effect of Rapamycin-induced Oxidative Stress on Thyroiditis Rats
Nan HUAI, Rui LI, Guangrong SONG, Anren KUANG
Abstract(37) PDF(1)
Gut-Brain Axis Mediated Mechanisms of SGLT-2Inhibitors in Enhancing Neural Repair after Ischemic Stroke
Ni MAO, Xiaoling WANG, Yanzhao ZHAI, Lei ZHANG
Abstract(28) PDF(1)
Correlation Between Expression of Serum LncRNA TUG1 and MiR-29a-3p and the Severity and Prognosis in Patients with Severe Pneumonia
Zhaozhao LIU, Jun ZHANG, Xiaobo FAN
Abstract(33) PDF(0)
Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
Display Method:
Study on the Mechanism by Which GPX4 Expression Promotes Ferroptosis and Participates in Malignant Behavior of Endometrial Carcinoma
Xiaoxia DONG, Shuxian CHEN
Abstract(107) PDF(80)
Comparative Analysis of caIMR and CMR in Assessing Coronary Microvascular Dysfunction and Correlation of Cardiac and Cerebral Microvascular Lesions
Min YU, Lin SUN
Abstract(153) PDF(9)
Disease Spectrum Analysis of Oral Cavity and Throat Malignant Tumors in the First People’s Hospital of Yunnan Province from 2012 to 2021Epidemiological Analysis of Head and Neck Malignant Tumors in a Hospital from 2012 to 2021
Fan WANG, Rong ZENG, Mao ZHANG, Yi REN, Hao DING
Abstract(186) PDF(6)
Molecular Mechanism of the YAP1/ANXA2 Signaling Axis in Regulating Apoptosis and Migration of Renal Tubular Epithelial Cells
Shaoting SUN, Lanmei LI, Weiwei BAI, Na CHEN, Meng WANG, Ming ZHANG, Yafen LI
Abstract(136) PDF(7)
Intervention of AKR1C3 on Malignant Biological Behavior of Breast Cancer Cells through PD1/PD-L1 Signaling Pathway
Jingjing SONG, Wei XIONG, Shuhui YAO, Shuang LIU, Jing ZHANG
Abstract(194) PDF(13)
Research Advances in D-dimer/Fibrinogen Ratio and Fibrinogen/Albumin Ratio in Acute Coronary Syndromes
Jizhou LI, Hongwei LI, Ye ZHANG, Hongling YANG
Abstract(186) PDF(7)
Effect of Xiyanping on Inflammatory Microenvironment of COPD Model Based on TLR3-MAPK Signaling Pathway
Juan LI, Meiling WANG, Lihong LIU
Abstract(213) PDF(10)
Impact of Hospital-Community-Family Linkage Model Intervention on Patients with Schizophrenia during the Post-Discharge Rehabilitation Period
Shu TAN, Jing ZENG, Runjuan MA, Wensa YIN
Abstract(249) PDF(17)
Relationship between Serum PON-1，NDRG4 and SFRP4 Expression，Peripheral Blood Immune Cell Distribution，and Prognosis in Gastric Cancer Patients
Tian TIAN, Xiaodong YANG, Shujie GE
Abstract(121) PDF(10)
Weight Gain Pattern during Pregnancy and Its Association with Delivery Fear and Cesarean Section Rate in Primiparous Women
Xiaoli CHAI, Li LI, Zhigang LIU, Wenyu YAN
Abstract(172) PDF(10)
Inhibitory Effect of Low-Molecular-Weight Heparin and Insulin Supplemented with Fenofibrate Capsules on Local Inflammation in Patients with Hypertriglyceridemic Acute Pancreatitis
Yao TANG, Ting XU, Jun WU
Abstract(137) PDF(10)
Gastrodin Ameliorates Maternal-Fetal Interface Injury in Gestational Diabetes Mellitus Rats by Activating the GPR120/AMPK Pathway
Nan LI, Ziyi NIU, Lan SHAO
Abstract(155) PDF(8)
Survey on Mental Disorders in HIV/AIDS Patients with End-stage Renal Disease on Hemodialysis
Guonian HE, Yongmei JIN, Bo TIAN, Shoukun CHEN, Nihong LU, Jun LIU
Abstract(156) PDF(16)
Studies on the Correlation between Esophageal Manometry and Short-Term Efficacy of Endoscopic Myomectomy in Patients with Achalasia
Yingye SONG, Juanping LI, Rui LI
Abstract(130) PDF(26)
Analysis of the Value of Serum Testosterone，Sex Hormone-Binding Globulin and Vitamin D Levels in Predicting Gestational Diabetes Mellitus Complicated by Polycystic Ovary Syndrome
Yuzhen ZHAO, Yingyan MA, Lili HE
Abstract(276) PDF(30)
Efficacy of Butylphthalide Combined with Atorvastatin in the Treatment of Cerebral Infarction and Its Effects on the Expression of vWF，PAI-1 and Ve Cadherin in Vascular Endothelium
Kejiao LI, Zichen LIU, Sha CHANG, Xue SONG, Fang LI
Abstract(63) PDF(0)
The Relationship between PBEF，KLF2，IL-26 and The Condition and Prognosis of Severe Pneumonia in Children
Yan ZHANG, Yun TANG
Abstract(70) PDF(6)
Expert Consensus on the Diagnosis and Treatment of Chronic Coronary Syndrome with Traditional Chinese and Western Medicine in Yunnan Province
Li ZHANG, Ying ZHANG, Xueya ZHANG, Zhuo YU
Abstract(378) PDF(15)
Column
Expert Forum
Regional and Ethnic-Specific Characteristics of the Gut Microbiome in China and Their Impact on Disease
Binbin XIA, Rongxue HUANG, Hongju YANG, Yang SUN
2025, 46(11): 1-10.    doi: 10.12259/j.issn.2095-610X.S20251101
Abstract(202) HTML PDF(19)
Original Articles Basic of Medicine
Expression of Cell Pyroptosis-Associated TLR4 Signalling Pathway During the Progression from Actinic Keratosis to Cutaneous Squamous Cell Carcinoma
Xiaoyu ZHAO, Minyan ZHANG, Huiya CHEN, Tingting CUI, Yuhan HUANG, Dan XU
2025, 46(11): 11-17.    doi: 10.12259/j.issn.2095-610X.S20251102
Abstract(142) HTML PDF(16)
The Role of APOE4 in Regulating LRP1 on Aβ25-35-Induced Oxidative Stress and Inflammatory Response in Astrocytes
Yanping LI, Efty Fariha Tasnim, Zhixing LU, Lingying ZHU
2025, 46(11): 18-25.    doi: 10.12259/j.issn.2095-610X.S20251103
Abstract(3) HTML PDF(2)
Investigating the Effect of Dihydroartemisinin on Proliferation and Metastasis of Prostate Cancer Cells based on the SPOP/HnRNPK Pathway
Jiantong ZHANG, Zhenzhuang GAO, Zhixiu WANG, Lina SUN
2025, 46(11): 26-34.    doi: 10.12259/j.issn.2095-610X.S20251104
Abstract(107) HTML PDF(80)
The Mechanism of miR-23 Regulating PI3K/AKT/mTOR Pathway to Improve Myocardial Angiogenesis in Hypertensive Heart Failure Rats
Haixing ZHANG, Jingyun ZHANG, Dandan XU, Lu CAO, Jingjing LI
2025, 46(11): 35-42.    doi: 10.12259/j.issn.2095-610X.S20251105
Abstract(139) HTML PDF(10)
Effects of MiR-126 on Myocardial Remodeling and Macrophage Polarization after Acute Myocardial Infarction
Jiaojiao HAN, Liwei AN, Yangyang XIE, Bin WANG, Jin WANG, Lijun ZHANG
2025, 46(11): 43-49.    doi: 10.12259/j.issn.2095-610X.S20251106
Abstract(63) HTML PDF(2)
Molecular Mechanism of Finasteride Inhibition of Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells under Hypoxia-Inducible Factor 1-alpha/Snail Family Transcriptional Repressor 1 Pathway
Hongyu CHEN, Lei YANG, Xiao WANG, Ling XIE
2025, 46(11): 50-57.    doi: 10.12259/j.issn.2095-610X.S20251107
Abstract(150) HTML PDF(11)
Mechanism by Which T Cell Immune Structural Proteins Promote the Role of the Hippo Pathway in the Pathogenesis of Preeclampsia
Weiyi ZHANG, Liping YANG, Jiancai MA
2025, 46(11): 58-64.    doi: 10.12259/j.issn.2095-610X.S20251108
Abstract(102) HTML PDF(7)
RBBP7 Promotes the Malignant Progression and Radioresistance of Esophageal Cancer through Hippo Signaling Pathway
Zhiyu MA, Jie ZHENG
2025, 46(11): 65-73.    doi: 10.12259/j.issn.2095-610X.S20251109
Abstract(153) HTML PDF(8)
Clinical Research
Analysis of Thalassemia Gene Screening and Diagnosis Results in the Dehong Population
Peng LI, Wei YI, Jie ZHANG, Yangjia ZHANG, Shijun GE
2025, 46(11): 74-80.    doi: 10.12259/j.issn.2095-610X.S20251110
Abstract(157) HTML PDF(15)
Analysis of Factors Influencing Recurrence in Osteosarcoma Patients and Construction of Nomogram Prediction Model
Guoyu MA, Xin YANG, Weilin SHAO, Chuqi QUAN, Xiaohui YANG, Zuozhang YANG, Zhihong YAO
2025, 46(11): 81-89.    doi: 10.12259/j.issn.2095-610X.S20251111
Abstract(181) HTML PDF(9)
The Levels of Serum CXCL5，TLR4，and MMP-3 in Gouty Arthritis Patients with Different Clinical Features and Their Correlation with the Joint Destruction and Serum Uric Acid Levels
Xiaohua LI, Yalu FU, Dan WANG
2025, 46(11): 90-99.    doi: 10.12259/j.issn.2095-610X.S20251112
Abstract(129) HTML PDF(11)
The Relationship between M1/M2 Macrophage Expression and the Severity of Diabetes Retinopathy
Nan HUO, Junbo ZHAO, Min WANG, Weiqiao AN, Cui CUI
2025, 46(11): 100-106.    doi: 10.12259/j.issn.2095-610X.S20251113
Abstract(45) HTML PDF(1)
Factors Influencing Respiratory Syncytial Virus Infection in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Correlation with Serum Levels of HSP70，KLF5，MIP-2
Xianbiao XU, Mingfang YANG, Ruidan LI, Li ZHANG
2025, 46(11): 107-115.    doi: 10.12259/j.issn.2095-610X.S20251114
Abstract(125) HTML PDF(12)
Correlation of Serum miR-21 and miR-23a Levels with Cognitive Function and Inflammatory Response in Patients with Parkinson’ s Disease
Zhiping HAN, Jing CHEN, Tao MA, Shaolan WANG, Jiandong LÜ
2025, 46(11): 116-121.    doi: 10.12259/j.issn.2095-610X.S20251115
Abstract(94) HTML PDF(8)
Application of Serum STAT3，HDAC2，and Del-1 Levels in the Evaluation of Disease Severity and Prognosis of Children with Respiratory Syncytial Virus Pneumonia
Hongyan CUI, Shuyang ZHANG, Wenwen ZHOU
2025, 46(11): 122-129.    doi: 10.12259/j.issn.2095-610X.S20251116
Abstract(108) HTML PDF(10)
Changes in Expression Levels and Clinical Significance of Park7 and P2X7R in the Serum of Patients with Acute Myocardial Infarction
Xuemei WANG, Haiqing CHEN, Lina CHEN
2025, 46(11): 130-137.    doi: 10.12259/j.issn.2095-610X.S20251117
Abstract(118) HTML PDF(7)
Changes in Ang-2 Levels Before and after Microwave Ablation Treatment in High-Risk Pulmonary Nodule Patients and Its Impact on Postoperative Recurrence
Yuxiang ZHOU, Guangjun MIAO, Honghong XIAN, Jiangrong LIAO
2025, 46(11): 138-147.    doi: 10.12259/j.issn.2095-610X.S20251118
Abstract(156) HTML PDF(11)
Review
Research Status and Clinical Application Progress of Peptide Drugs
Qiqi PEI, Qian CHEN, Hanying WANG, Li TIAN, Guizhu FENG
2025, 46(11): 148-159.    doi: 10.12259/j.issn.2095-610X.S20251119
Abstract(238) HTML PDF(88)
Teaching Research
Research on an Educational Milestone System for Nursing Students in Bachelor's，Master's，and Doctoral Programs
Yuxin HAN, Yu ZHANG, Xinhui WANG, Yuping LI, Rong RONG, Shuowei ZHANG
2025, 46(11): 160-171.    doi: 10.12259/j.issn.2095-610X.S20251120
Abstract(131) HTML PDF(15)
Nursing Forum
A Study on the Application of the Timing-It-Right Framework Combined with Phase I Cardiac Rehabilitation Model in Patients Undergoing Transcatheter Aortic Valve Replacement
Wenmin CHEN, Jinghong PI, Xintong FU, Yueqing CHEN, Hua LI, Zheng JIA
2025, 46(11): 172-178.    doi: 10.12259/j.issn.2095-610X.S20251121
Abstract(138) HTML PDF(12)

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