大剂量盐酸氨溴索治疗早产儿呼吸窘迫综合征疗效观察
Therapeutic Effect of Large Dose of Mucosolvan on Respiratory Distress Syndrome in Premature Children
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摘要: 目的 探讨盐酸氨溴索对治疗早产儿呼吸窘迫综合征的疗效.方法 将72例NRDS早产儿随机分成治疗组37例和对照组35例.两组均给予相同综合基础治疗及鼻塞式cpap给氧,治疗组加用盐酸氨溴索注射液30 mg/(kg.d)分4次静脉给药,比较两组在治疗后48 h的临床表现及血气变化,(PaO2、PaCO2及PaO2/FiO2).结果 治疗组21例经治疗48 h后,呼吸困难和呻吟明显减轻或消失,血PaO2升高,PaCO2降低,氧和参数明显增加.两组疗效及血气,氧和指数比较有显著性差异.结论 在早产儿呼吸窘迫综合征常规治疗的基础上加用大剂量盐酸氨溴索有较好疗效,可以减少病死率,提高存活率.Abstract: Objective To investigate the therapeutic effect of large dose of mucosolvan on respiratory distress syndrome in premature children.Methods Seventy-two premature children with NRDS were randomly divided into treatment group(37 cases)and control group(35 cases),all cases were given same combined therapy and variant flow rate continuous positive airway by nasal mask.The cases in treatment group were given 30 mg/(kg.d)of mucosolvan for four times.The clinical symptoms and blood gas analysis(PaO2,PaCO2,PaO2/FiO2...
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Key words:
- Ambroxol hydrochloride /
- Respiratory distress syndrome /
- Neonatal /
- Premature children
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