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根尖牙乳头干细胞成骨分化的研究进展

钱石兵 史会萍 李艳秋 杨镕羽 段开文

钱石兵, 史会萍, 李艳秋, 杨镕羽, 段开文. 根尖牙乳头干细胞成骨分化的研究进展[J]. 昆明医科大学学报, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926
引用本文: 钱石兵, 史会萍, 李艳秋, 杨镕羽, 段开文. 根尖牙乳头干细胞成骨分化的研究进展[J]. 昆明医科大学学报, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926
Shibing QIAN, Huiping SHI, Yanqiu LI, Rongyu YANG, Kaiwen DUAN. Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells[J]. Journal of Kunming Medical University, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926
Citation: Shibing QIAN, Huiping SHI, Yanqiu LI, Rongyu YANG, Kaiwen DUAN. Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells[J]. Journal of Kunming Medical University, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926

根尖牙乳头干细胞成骨分化的研究进展

doi: 10.12259/j.issn.2095-610X.S20240926
基金项目: 国家自然科学基金资助项目(81160135);云南省生物医药重大科技专项基金(202102AA100007);云南省教育厅科学研究基金教师类项目(2024J1609)
详细信息
    作者简介:

    钱石兵(1996~),男,云南曲靖人,医学硕士,助教,主要从事牙周病和口腔黏膜疾病的防治工作

    通讯作者:

    段开文,E-mail:kwduan@aliyun.com

  • 中图分类号: R78

Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells

  • 摘要: 根尖牙乳头干细胞(stem cells from apical papilla,SCAP)具有很强的多系分化潜能,其中成骨分化可以应用于骨组织再生,为口腔颌骨缺损治疗提供新思路。成骨分化是个复杂的网络调控过程,诸如各种细胞因子、表观遗传物质、各种信号分子和信号通路等内源性物质均可产生不同程度的影响。这些因素相互作用可以促进SCAP的增殖、迁移和成骨分化,但其在SCAP成骨分化的不同进程中的具体机制和内在联系各不相同。对近年来有关促进SCAP成骨分化的各种因素及其可能的调控机制研究文献进行综述,以期为其进一步的应用研究提供新信息。
  • [1] Morsczeck C. Dental stem cells for tooth regeneration: how far have we come and where next?[J]. Expert Opin Biol Ther,2023,23(6):527-537. doi: 10.1080/14712598.2023.2208268
    [2] Sonoyama W,Liu Y,Fang D,et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine[J]. PLoS One,2006,1(1):e79-86. doi: 10.1371/journal.pone.0000079
    [3] Liu Q,Gao Y,He J. Stem cells from the apical papilla (SCAPs): past,present,prospects,and challenges[J]. Biomedicines,2023,11(7):2047-2059. doi: 10.3390/biomedicines11072047
    [4] Bakopoulou A,Leyhausen G,Volk J,et al. Comparative analysis of in vitro osteo/odontogenic differentiation potential of human dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAP)[J]. Arch Oral Biol,2011,56(7):709-721. doi: 10.1016/j.archoralbio.2010.12.008
    [5] Chen K,Xiong H,Huang Y,et al. Comparative analysis of in vitro periodontal characteristics of stem cells from apical papilla (SCAP) and periodontal ligament stem cells (PDLSCs)[J]. Arch Oral Biol,2013,58(8):997-1006. doi: 10.1016/j.archoralbio.2013.02.010
    [6] Chang H H,Chang M C,Wu I H,et al. Role of ALK5/Smad2/3 and MEK1/ERK signaling in transforming growth factor beta 1-modulated growth,collagen turnover,and differentiation of stem cells from apical papilla of human tooth[J]. J Endod,2015,41(8):1272-1280. doi: 10.1016/j.joen.2015.03.022
    [7] Li J,Ge L,Zhao Y,et al. TGF-beta2 and TGF-beta1 differentially regulate the odontogenic and osteogenic differentiation of mesenchymal stem cells[J]. Arch Oral Biol,2022,64(3):105357.
    [8] Yu S,Li J,Zhao Y,et al. Comparative secretome analysis of mesenchymal stem cells from dental apical papilla and bone marrow during early odonto/osteogenic differentiation: potential role of transforming growth factor-beta2[J]. Front Physiol,2020,11(3):41-53.
    [9] Zhang W,Zhang X,Ling J,et al. Proliferation and odontogenic differentiation of BMP2 genetransfected stem cells from human tooth apical papilla: an in vitro study[J]. Int J Mol Med,2014,34(4):1004-1012. doi: 10.3892/ijmm.2014.1862
    [10] Zhang W,Zhang X,Li J,et al. Foxc2 and BMP2 induce osteogenic/odontogenic differentiation and mineralization of human stem cells from apical papilla[J]. Stem Cells Int,2018,9(7):2363917.
    [11] Zhang W,Zhang X,Ling J,et al. Osteo-/odontogenic differentiation of BMP2 and VEGF gene-co-transfected human stem cells from apical papilla[J]. Mol Med Rep,2016,13(5):3747-3754. doi: 10.3892/mmr.2016.4993
    [12] Press T,Viale-Bouroncle S,Felthaus O,et al. EGR1 supports the osteogenic differentiation of dental stem cells[J]. Int Endod J,2015,48(2):185-192. doi: 10.1111/iej.12299
    [13] Wang J,Zhang H,Zhang W,et al. Bone morphogenetic protein-9 effectively induces osteo/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla[J]. Stem Cells Dev,2014,23(12):1405-1416. doi: 10.1089/scd.2013.0580
    [14] Wang F,Jiang Y,Huang X,et al. Pro-Inflammatory cytokine TNF-alpha attenuates BMP9-induced osteo/ odontoblastic differentiation of the stem cells of dental apical papilla (SCAPs)[J]. Cell Physiol Biochem,2017,41(5):1725-1735. doi: 10.1159/000471865
    [15] Zhang H,Wang J,Deng F,et al. Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs)[J]. Biomaterials,2015,39(1):145-154.
    [16] Zhu X Y,Diao S,Yang D M,et al. The Mechanism of GREM1's effect on osteogenic/odontogenic differentiation of stem cells from apical papilla[J]. Sichuan Da Xue Xue Bao Yi Xue Ban,2021,52(3):409-415.
    [17] Wang S,Mu J,Fan Z,et al. Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla[J]. Stem Cell Res,2012,8(3):346-356. doi: 10.1016/j.scr.2011.12.005
    [18] Wang Y,Pang X,Wu J,et al. MicroRNA hsa-let-7b suppresses the odonto/osteogenic differentiation capacity of stem cells from apical papilla by targeting MMP1[J]. J Cell Biochem,2018,119(8):6545-6554. doi: 10.1002/jcb.26737
    [19] Ma S,Liu G,Jin L,et al. IGF-1/IGF-1R/hsa-let-7c axis regulates the committed differentiation of stem cells from apical papilla[J]. Sci Rep,2016,6(11):36922-36933.
    [20] Cao Y,Xia D S,Qi S R,et al. Epiregulin can promote proliferation of stem cells from the dental apical papilla via MEK/Erk and JNK signalling pathways[J]. Cell Prolif,2013,46(4):447-456. doi: 10.1111/cpr.12039
    [21] Li Y,Yan M,Wang Z,et al. 17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway[J]. Stem Cell Res Ther,2014,5(6):125-149. doi: 10.1186/scrt515
    [22] Wang Y,Lu Y,Li Z,et al. Oestrogen receptor alpha regulates the odonto/osteogenic differentiation of stem cells from apical papilla via ERK and JNK MAPK pathways[J]. Cell Prolif,2018,51(6):e12485-12494. doi: 10.1111/cpr.12485
    [23] Pang X,Zhuang Y,Li Z,et al. Intermittent administration of parathyroid hormone enhances odonto/osteogenic differentiation of stem cells from the apical papilla via JNK and P38 MAPK pathways[J]. Stem Cells Int,2020,11(2):5128128.
    [24] Zhang J,Zhao I S,Yu O Y,et al. Layer-by-layer self-assembly polyelectrolytes loaded with cyclic adenosine monophosphate enhances the osteo/odontogenic differentiation of stem cells from apical papilla[J]. J Biomed Mater Res A,2021,109(2):207-218. doi: 10.1002/jbm.a.37017
    [25] Su S,Zhu Y,Li S,et al. The transcription factor cyclic adenosine 3',5'-monophosphate response element-binding protein enhances the odonto/osteogenic differentiation of stem cells from the apical papilla[J]. Int Endod J,2017,50(9):885-894. doi: 10.1111/iej.12709
    [26] Zhang Y,Yuan L,Meng L,et al. Guanine and nucleotide binding protein 3 promotes odonto/osteogenic differentiation of apical papilla stem cells via JNK and ERK signaling pathways[J]. Int J Mol Med,2019,43(1):382-392.
    [27] Xiao M,Yao B,Zhang B D,et al. Stromal-derived Factor-1alpha signaling is involved in bone morphogenetic protein-2-induced odontogenic differentiation of stem cells from apical papilla via the Smad and Erk signaling pathways[J]. Exp Cell Res,2019,381(1):39-49. doi: 10.1016/j.yexcr.2019.04.036
    [28] Liu J,Wang X,Song M,et al. MiR-497-5p regulates osteo/odontogenic differentiation of stem cells from apical papilla via the smad signaling pathway by targeting smurf2[J]. Front Genet,2020,11(10):582366.
    [29] Li Z,Ge X,Lu J,et al. MiR-141-3p regulates proliferation and senescence of stem cells from apical papilla by targeting YAP[J]. Exp Cell Res,2019,383(2):111562. doi: 10.1016/j.yexcr.2019.111562
    [30] Xiao Y,Chen L,Xu Y,et al. Circ-ZNF236 mediates stem cells from apical papilla differentiation by regulating LGR4-induced autophagy[J]. Int Endod J,2024,57(4):431-450. doi: 10.1111/iej.14021
    [31] Jia Q,Chen X,Jiang W,et al. The regulatory effects of long noncoding RNA-ANCR on dental tissue-derived stem cells[J]. Stem Cells Int,2016,7(8):3146805.
    [32] Wang L,Yang H,Lin X,et al. KDM1A regulated the osteo/dentinogenic differentiation process of the stem cells of the apical papilla via binding with PLOD2[J]. Cell Prolif,2018,51(4):e12459-12467. doi: 10.1111/cpr.12459
    [33] Diao S,Yang D M,Dong R,et al. Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced osteogenic differentiation potentials of stem cells from apical papilla[J]. J Endod,2015,41(2):205-211. doi: 10.1016/j.joen.2014.09.027
    [34] Gao R,Dong R,Du J,et al. Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15INK4B and p27Kip1[J]. Mol Cell Biochem,2013,379(1-2):115-122. doi: 10.1007/s11010-013-1633-7
    [35] Su X,Yang H,Shi R,et al. Depletion of SNRNP200 inhibits the osteo-/dentinogenic differentiation and cell proliferation potential of stem cells from the apical papilla[J]. BMC Dev Biol,2020,20(1):22-32. doi: 10.1186/s12861-020-00228-y
    [36] Xu J,Yu B,Hong C,et al. KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells[J]. Int J Oral Sci,2013,5(4):200-205. doi: 10.1038/ijos.2013.77
    [37] Li W,Lin X,Yang H,et al. Depletion of HOXA5 inhibits the osteogenic differentiation and proliferation potential of stem cells from the apical papilla[J]. Cell Biol Int,2018,42(1):45-52. doi: 10.1002/cbin.10860
    [38] Gao R T,Zhan L P,Meng C,et al. Homeobox B7 promotes the osteogenic differentiation potential of mesenchymal stem cells by activating RUNX2 and transcript of BSP[J]. Int J Clin Exp Med,2015,8(7):10459-10470.
    [39] Yang H,Liang Y,Cao Y,et al. Homeobox C8 inhibited the osteo-/dentinogenic differentiation and migration ability of stem cells of the apical papilla via activating KDM1A[J]. J Cell Physiol,2020,235(11):8432-8445. doi: 10.1002/jcp.29687
    [40] Wu Z,Wang J,Dong R,et al. Depletion of MEIS2 inhibits osteogenic differentiation potential of human dental stem cells[J]. Int J Clin Exp Med,2015,8(5):7220-7230.
    [41] Yang H,Fan J,Cao Y,et al. Distal-less homeobox 5 promotes the osteo-/dentinogenic differentiation potential of stem cells from apical papilla by activating histone demethylase KDM4B through a positive feedback mechanism[J]. Exp Cell Res,2019,374(1):221-230. doi: 10.1016/j.yexcr.2018.11.027
    [42] Yang H,Cao Y,Zhang J,et al. DLX5 and HOXC8 enhance the chondrogenic differentiation potential of stem cells from apical papilla via LINC01013[J]. Stem Cell Res Ther,2020,11(1):271-286. doi: 10.1186/s13287-020-01791-8
    [43] Wan F,Gao L,Lu Y,et al. Proliferation and osteo/odontogenic differentiation of stem cells from apical papilla regulated by Zinc fingers and homeoboxes 2: An in vitro study[J]. Biochem Biophys Res Commun,2016,469(3):599-605. doi: 10.1016/j.bbrc.2015.11.135
    [44] Zhang J,Wang Z,Jiang Y,et al. Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro[J]. Exp Cell Res,2015,332(2):259-266. doi: 10.1016/j.yexcr.2015.01.020
    [45] Wang H,Cao Y. WIF1 enhanced dentinogenic differentiation in stem cells from apical papilla[J]. BMC Oral Health,2019,19(1):25-32. doi: 10.1186/s12903-018-0700-6
    [46] Jin L,Cao Y,Yu G,et al. SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway[J]. Cell Mol Biol Lett,2017,22(8):14-27.
    [47] Yang H,Li G,Han N,et al. Secreted frizzled-related protein 2 promotes the osteo/odontogenic differentiation and paracrine potentials of stem cells from apical papilla under inflammation and hypoxia conditions[J]. Cell Prolif,2020,53(1):e12694-12704. doi: 10.1111/cpr.12694
    [48] Zhou M,Guo S,Yuan L,et al. Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae[J]. J Mol Histol,2017,48(5-6):389-401. doi: 10.1007/s10735-017-9737-0
    [49] Cheng Q,Zeng K,Kang Q,et al. The antimicrobial peptide LL-37 promotes migration and odonto/osteogenic differentiation of stem cells from the apical papilla through the Akt/Wnt/beta-catenin signaling pathway[J]. J Endod,2020,46(7):964-972. doi: 10.1016/j.joen.2020.03.013
    [50] Liu J,Du J,Chen X,et al. The effects of mitogen-activated protein kinase signaling pathways on lipopolysaccharide-mediated osteo/odontogenic differentiation of stem cells from the apical papilla[J]. J Endod,2019,45(2):161-167. doi: 10.1016/j.joen.2018.10.009
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出版历程
  • 收稿日期:  2023-12-05
  • 网络出版日期:  2024-09-03
  • 刊出日期:  2024-09-25

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