Expression and Significance of CARP, Myo and α1-microglobulin in Serum of Patients with Acute Myocardial Infarction

Zhen-lin XIE; Ya-jian FENG; Zhi-wei FAN; Dong-xing ZHANG

doi:10.12259/j.issn.2095-610X.S20211123

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Zhen-lin XIE, Ya-jian FENG, Zhi-wei FAN, Dong-xing ZHANG. Expression and Significance of CARP, Myo and α1-microglobulin in Serum of Patients with Acute Myocardial Infarction[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S20211123

Citation:

Zhen-lin XIE, Ya-jian FENG, Zhi-wei FAN, Dong-xing ZHANG. Expression and Significance of CARP, Myo and α1-microglobulin in Serum of Patients with Acute Myocardial Infarction[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S20211123

Citation:

Zhen-lin XIE, Ya-jian FENG, Zhi-wei FAN, Dong-xing ZHANG. Expression and Significance of CARP, Myo and α1-microglobulin in Serum of Patients with Acute Myocardial Infarction[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S20211123

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Expression and Significance of CARP, Myo and α1-microglobulin in Serum of Patients with Acute Myocardial Infarction

doi: 10.12259/j.issn.2095-610X.S20211123

Emergency Internal Medicine，Affiliated Zhongda Hospital of Southeast University ， Jiangsu Nanjing 210009，China

Received Date: 2021-09-11

Abstract

Abstract

Objective To explore the expression and significance of CARP, Myo and α 1-microglobulin in serum of patients with acute myocardial infarction. Methods From February 2019 to August 2019, 65 patients with acute myocardial infarction who were treated in our hospital were selected as the AMI group of this study, and 65 healthy volunteers who received routine physical examination in our hospital at the same time were selected as the control group of this study. Serum cardiac anchor repeat protein （CARP） was detected by enzyme-linked immunosorbent assay （ELISA）, Myo level by chemiluminescent immunoassay, α1-microglobulin, cTnI, HS-TnI level by immunoturbidimetry. Results Compared with the control group, the levels of serum CARP, myoglobin, α1-microglobulin, cTnI and HS-TnI in AMI group were higher, the difference was statistically significant （P<0.05）. CARP and Myo were positively correlated in AMI （r = 0.399, P = 0.001）; CARP and α1-microglobulin were positively correlated in AMI （r = 0.446, P = 0.001）; Myo and α1-microglobulin were positively correlated in AMI （r = 0.463, P = 0.001）. There was a positive correlation between the levels of cTnI and HS-TnI. Conclusions The levels of CARP, Myo and α1-microglobulin are abnormally increased in acute myocardial infarction, which has a certain correlation with the levels of cTnI and HS-TnI. The detection of CARP, Myo and α1-microglobulin can provide an important reference for the early diagnosis, treatment and prognosis of patients with acute myocardial infarction, and has a certain clinical value.
- Anchor repeat protein,
- Myoglobin,
- α1-microglobulin,
- Acute myocardial infarction

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References(20)

References

[1]	丁晓松,李虹伟. 急性心肌梗死合并高血糖的诊治[J]. 中国糖尿病杂志,2019,27(12):956-958.
[2]	孙达,常静,林莉莉. 川芎嗪治疗急性心肌梗死大鼠的作用机制研究[J]. 中国临床药理学杂志,2019,35(24):3208-3212.
[3]	孙润民,王琼英,齐苗苗,等. 急性心肌梗死后心力衰竭预测因素的研究进展[J]. 中华心血管病杂志,2019,47(11):923-926.
[4]	黄玲芳,狄宁宁,周松. 替格瑞洛联合匹伐他汀治疗急性心肌梗死临床研究[J]. 中国药业,2020,29(1):83-86.
[5]	龚艳君,霍勇. 急性ST段抬高型心肌梗死诊断和治疗指南(2019)解读[J]. 中国心血管病研究,2019,17(12):1057-1061. doi: 10.3969/j.issn.1672-5301.2019.12.001
[6]	Sezai Y S,Kudret K,Murat A,et al. Electrocardiographic diagnosis of atrial infarction in patients with acute inferior ST-segment elevation myocardial infarction[J]. Clinical Cardiology,2018,41(7):237-243.
[7]	Martovytskyi D V,Shelest O M,et al. Effect of endostatin and insulin-like growth factor-1 on angiogenesis in patients with acute myocardial infarction with obesity under the influence of zofenopril[J]. Wiad Lek,2020,73(1):63-67.
[8]	温志浩,卢健棋,潘朝锌,等. 益气活血通阳法不同配比对急性心肌梗死兔血管生成因子影响的研究[J]. 现代中西医结合杂志,2019,28(34):3768-3772,3806.
[9]	孟萌,魏佳丽,潘红,等. 血清HMGB1、sTLT-1水平对经皮冠状动脉介入治疗急性心肌梗死患者预后的影响[J]. 中国现代医学杂志,2019,29(24):38-43. doi: 10.3969/j.issn.1005-8982.2019.24.007
[10]	李霖,刘劲,黄创,等. 急性心肌梗死后心室重构患者超敏C反应蛋白及胱抑素C检测的临床价值研究[J]. 河北医学,2019,25(12):2045-2049.
[11]	张福伟,谢倩,陈漠水,等. 急性ST段抬高型心肌梗死患者血清心锚重复蛋白与高敏C反应蛋白、肌酸激酶同工酶、心肌肌钙蛋白I相关性研究[J]. 中华危重症医学杂志(电子版),2017,10(2):82-86. doi: 10.3877/cma.j.issn.1674-6880.2017.02.003
[12]	匡荣仁,原丽萍,贺献芝,等. 三七总皂苷联合胺碘酮对阵发性房颤左心房内径和心锚重复蛋白的影响[J]. 天津中医药,2018,35(8):573-575.
[13]	陈铭,廖禹林. 心肌锚定重复蛋白与心力衰竭之间的关系[J]. 广东医学,2011,32(23):3139-3141. doi: 10.3969/j.issn.1001-9448.2011.23.048
[14]	郝欣阳,刘洪梅,袁梦,等. 冠心病合并糖尿病患者血清CARP水平与冠脉病变关系的研究[J]. 天津医科大学学报,2017,23(4):337-339.
[15]	涂为民. 脑钠肽、肌红蛋白在慢性心力衰竭患者诊断中的临床价值[J]. 检验医学与临床,2019,16(21):3184-3186. doi: 10.3969/j.issn.1672-9455.2019.21.034
[16]	赵健红,丁阿凤. 心力衰竭患者血清心型脂肪酸结合蛋白肌钙蛋白T肌红蛋白N末端脑钠肽前体的检测及影响[J]. 山西医药杂志,2019,48(14):1699-1701. doi: 10.3969/j.issn.0253-9926.2019.14.022
[17]	林文利. 肌酸激酶血清肌红蛋白及炎症相关因子的动态监测在多发伤并发多器官功能障碍综合征诊断中的价值[J]. 山西医药杂志,2019,48(21):2594-2597.
[18]	温志浩,卢健棋,潘朝锌,等. 益气活血通阳法不同配比对急性心肌梗死兔血管生成因子影响的研究[J]. 现代中西医结合杂志,2019,28(34):3768-3772,3806.
[19]	Hakuno D,Kimura M,Nakashima Y,et al. Hepatokine a1-microglobulin signaling alters macrophage polarization,exacerbates acute inflammation and adverse left ventricular remodeling in myocardial infarction[J]. Journal of the American College of Cardiology,2019,73(9):47. doi: 10.1016/S0735-1097(19)30656-4
[20]	黄静,黄志刚,黄亨建. 血清α1-微球蛋白、尿激肽原1联合检测在糖尿病肾病患者诊断中的临床价值[J]. 实用医院临床杂志,2019,16(6):12-15. doi: 10.3969/j.issn.1672-6170.2019.06.004

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