Correlation Analysis between Pathological Features of IgA Nephropathy and Dyslipidemia

Jingshan CHEN; Li LI; Shili SHANG; Guoyong HE; Wenjing ZHOU; Sha LI; Di ZHANG; Yonglan LIU; Jun LI

doi:10.12259/j.issn.2095-610X.S20230111

Volume 44 Issue 1

Jan. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(1): 47-53

Jingshan CHEN, Li LI, Shili SHANG, Guoyong HE, Wenjing ZHOU, Sha LI, Di ZHANG, Yonglan LIU, Jun LI. Correlation Analysis between Pathological Features of IgA Nephropathy and Dyslipidemia[J]. Journal of Kunming Medical University, 2023, 44(1): 47-53. doi: 10.12259/j.issn.2095-610X.S20230111

Citation:

Jingshan CHEN, Li LI, Shili SHANG, Guoyong HE, Wenjing ZHOU, Sha LI, Di ZHANG, Yonglan LIU, Jun LI. Correlation Analysis between Pathological Features of IgA Nephropathy and Dyslipidemia[J]. Journal of Kunming Medical University, 2023, 44(1): 47-53. doi: 10.12259/j.issn.2095-610X.S20230111

Citation:

Jingshan CHEN, Li LI, Shili SHANG, Guoyong HE, Wenjing ZHOU, Sha LI, Di ZHANG, Yonglan LIU, Jun LI. Correlation Analysis between Pathological Features of IgA Nephropathy and Dyslipidemia[J]. Journal of Kunming Medical University, 2023, 44(1): 47-53. doi: 10.12259/j.issn.2095-610X.S20230111

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Correlation Analysis between Pathological Features of IgA Nephropathy and Dyslipidemia

doi: 10.12259/j.issn.2095-610X.S20230111

1.
Dept.of Nephrology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept.of Nephrology，The 1st People’s Hospital of Kunming， Kunming Yunnan 650200，China

Received Date: 2022-11-14
Available Online: 2022-12-23
Publish Date: 2023-01-18

Abstract

Abstract

Objective To investigate the relationship between dyslipidemia and its clinical features and renal pathological features in patients with IgA nephropathy. Methods 150 patients with lgA nephropathy were divided into dyslipidemia group and normal blood lipid group, according to the blood lipid level. The dyslipidemia group was further divided into hypercholesterolemia group, hypertriglyceridemia group, mixed hyperlipidemia group and low high density lipoproteinemia group according to the types of dyslipidemia. The clinical features and pathological characteristics of each group. Results Compared with normal blood lipid group, BMI, urea, creatinine, uric acid and 24h-UP of abnormal blood lipid group were significantly higher （P < 0.05）, albumin, eGFR in dyslipidemia group were lower （P < 0.05）. Between different types of dyslipidemia, serum uric acid in hypertriglyceridemia group was higher than that in other dyslipidemia groups （P < 0.05）.The serum albumin in mixed hyperlipidemia group was lower than that in other dyslipidemia groups （P < 0.05）, while the 24-hour urine protein content was higher than that in other dyslipidemia groups （P < 0.05）. The proportion of Lee’s pathological grade Ⅲ-Ⅴ in dyslipidemia group was higher than that in normal blood lipid group, and the difference was statistically significant （P < 0.05）.The proportion of T1 and T2 in dyslipidemia group was higher than that in the normal blood lipid group （P < 0.05）. Multivariatelogistic regression analysis showed that BMI was a high-risk factor for dyslipidemia in patients with IgA nephropathy. Conclusions Dyslipidemia can predict the disease and progression of IgAN. The dyslipidemia group has more severe renal clinical features and pathological grading, and is more pronounced in tubular atrophy/interstitial fibrosis.Elevated BMI is a highrisk factor for dyslipidemia in IgAN patients.
- IgA nephropathy,
- Dyslipidemia,
- Pathological,
- Clinical features,
- Risk factors

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References(19)

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