Correlation between DDAH1 Gene 836A/T Polymorphism and Type 2 Diabetic Kidney Disease in Yunnan Han Population

Hong TAN; Hejia YIN; Yan LI; Qin HU; Lan LI; Zundan REN; Rou SHI

doi:10.12259/j.issn.2095-610X.S20230621

Volume 44 Issue 6

Jun. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2023 > 44(6): 26-32

Hong TAN, Hejia YIN, Yan LI, Qin HU, Lan LI, Zundan REN, Rou SHI. Correlation between DDAH1 Gene 836A/T Polymorphism and Type 2 Diabetic Kidney Disease in Yunnan Han Population[J]. Journal of Kunming Medical University, 2023, 44(6): 26-32. doi: 10.12259/j.issn.2095-610X.S20230621

Citation:

Hong TAN, Hejia YIN, Yan LI, Qin HU, Lan LI, Zundan REN, Rou SHI. Correlation between DDAH1 Gene 836A/T Polymorphism and Type 2 Diabetic Kidney Disease in Yunnan Han Population[J]. Journal of Kunming Medical University, 2023, 44(6): 26-32. doi: 10.12259/j.issn.2095-610X.S20230621

Citation:

Hong TAN, Hejia YIN, Yan LI, Qin HU, Lan LI, Zundan REN, Rou SHI. Correlation between DDAH1 Gene 836A/T Polymorphism and Type 2 Diabetic Kidney Disease in Yunnan Han Population[J]. Journal of Kunming Medical University, 2023, 44(6): 26-32. doi: 10.12259/j.issn.2095-610X.S20230621

PDF( 1278 KB)

Correlation between DDAH1 Gene 836A/T Polymorphism and Type 2 Diabetic Kidney Disease in Yunnan Han Population

doi: 10.12259/j.issn.2095-610X.S20230621

Hong TAN¹,
Hejia YIN¹,
Yan LI¹,
Qin HU¹,
Lan LI¹,
Zundan REN²,
Rou SHI^{1
,
,}

1.
Dept. of Endocrinology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
The 1st School of Clinical Medicine，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-02-24
Available Online: 2023-06-16
Publish Date: 2023-06-25

Abstract

Abstract

objective To investigate the association between DDAH1 gene 836A/T polymorphism and type 2 diabetic kidney disease （DKD） in Yunnan Han population. Methods A total of 660 patients with T2DM were included. Patients were divided into three groups based on UACR results: simple type 2 diabetes mellitus group （DN0 group）, complicated with early nephropathy group （DN1 group）, and complicated with clinical nephropathy group （DN2 group）. A total of 304 healthy people were included as normal control group （NC group）. The genotype of DDAH1 gene 836A/T polymorphism was determined by PCR-DNA sequencing. The plasma asymmetric dimethylarginine （ADMA）concentration was measured by ELISA. Results The distribution frequency of AA genotype and allele A at the 836 locus of DDAH1 gene in the DN1+DN2 group was significantly higher than those in the DN0 group （P < 0.05）. AA genotype carriers have higher ADMA levels than AT+TT genotype individuals in T2DM patients. The level of ADMA in DN1+DN2 group was higher than that in DN0 group （P < 0.05）. Logistic regression analysis showed that ADMA level and DDAH1 gene 836 AA genotype were risk factors for DKD in T2DM patients. Conclusions The DDAH1 gene 836 AA genotype may be a risk factor for diabetic kidney disease in T2DM patients of Han nationality in Yunnan Province, and patients with this genotype have higher ADMA levels.
- Type 2 diabetes mellitus,
- diabetic kidney disease,
- DDAH1,
- ADMA,
- Genetic polymorphism

FullText(HTML)

References(22)

References

[1]	American Diabetes Association Professional Practice Committee. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2022. Amer diabet assoc professional pra jan 2022[J]. Diabetes Care,2022,45(9):S17-S38.
[2]	Alhaider A A,Korashy H M,Sayed-Ahmed M M,et al. Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression[J]. Chem Biol Interact,2011,192(3):233-242. doi: 10.1016/j.cbi.2011.03.014
[3]	Michael D W,Ting G,Kristen S,et al. Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy[J]. America Journal Of Physiology-Renal Physiology,2020,318(2):509-517. doi: 10.1152/ajprenal.00518.2019
[4]	Mannino G C,Pezzilli S,Averta C,et al. A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients[J]. Cardiovasc Diabetol.,2019,18(1):102. doi: 10.1186/s12933-019-0906-1
[5]	Rhys D. Fogarty,Sotoodeh Abhary,Shahrbanou Javadiyan,et al. Rlationship between DDAH gene variants and serum a ADMA level in individuals with type 1 diabetes[J]. Diabetes Complications,2012,26(3):195-198. doi: 10.1016/j.jdiacomp.2012.03.022
[6]	中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中华糖尿病杂志,2018,10(1):4-67. doi: 10.3760/cma.j.issn.1674-5809.2018.01.003
[7]	石柔,张娴,谭洪,等. 云南地区汉族2型糖尿病患者二甲基精氨酸二甲胺水解酶1、二甲基精氨酸二甲胺水解酶2基因单核苷酸多态性与动脉粥样硬化关系的研究[J]. 中国糖尿病杂志,2021,29(5):321-327. doi: 10.3969/j.issn.1006-6187.2021.05.001
[8]	Dagar N,Das P,Bisht P,et al. Diabetic nephropathy: A twisted thread to unravel[J]. Life Sciences,2021,278(8):119635.
[9]	Creager M A,Luscher T F,Cosentino F,et al. Diabetes and vascular disease: pathophysiology,clinical consequences,and medical therapy: Part I[J]. Circulation,2003,108(12):1527-1532. doi: 10.1161/01.CIR.0000091257.27563.32
[10]	Wieczor R,Wieczor A M,Rosc D J,et al. ADMA (asymmetric dimethylarginine) and angiogenic potential in patients with type 2 diabetes and prediabetes[J]. Experimental Biology and Medicine,2020,246(2):153-162.
[11]	Mihout F,Shweke N,N Big´e,et al. Asymmetric dimethylarginine(ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-β1 synthesis[J]. The Journal of Pathology,2011,223(1):37-45. doi: 10.1002/path.2769
[12]	Mei Rong D,Gui Xia J,Nian Sheng L,et al. Role of Asymmetrical Dimethyl- arginine in Diabetic Microvascular Complications[J]. Journal of Cardiovascular Pharmacology,2016,68(4):322-326. doi: 10.1097/FJC.0000000000000414
[13]	Jing L,Caiying L,Wen C,et al. Relationship between serum asymmetric dimethylarginine level and microvascular complications in diabetes mellitus:A meta-analysis[J]. BioMed Research International,2019,2019:2941861.
[14]	Isaivani J,Saravanakumar S,Prabu P,et al. Association of circulatory asymmetric dimethylarginine (ADMA) with diabetic nephropathy in Asian Indians and its causative role in renal cell injury[J]. Clinical Biochemistry,2017,50(15):835-842. doi: 10.1016/j.clinbiochem.2017.05.007
[15]	Hu X,Atzler D,Xu X,et al. Dimethylarginine dimethylaminoh ydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine[J]. Arterioscler Thromb Vasc Biol,2011,31(1):1540-1546.
[16]	Roman N R,Natalia J,Alfred S,et al. ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus[J]. Atherosclerosis Supplements,2019,30:319-325.
[17]	Shi L L,Zhao C Y,Wang H Y,et al. Dimethylarginine dimethylamin ohydrolase 1 deficiency induces the epithelial to mesenchymal transition in renal proximal tubular epithelial cells and exacerbates kidney damage in aged and diabetic mice[J]. Antioxidants & Redox Signaling,2017,27(16):1347-1360.
[18]	Abhary S,Burdon K P,Kuot A,et al. Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with Type 2 diabetes[J]. Plos One,2010,5(3):e9462. doi: 10.1371/journal.pone.0009462
[19]	Lind L,Ingelsson E,Kumar J,et al. Genetic variation in the dimethylarginine dimethylaminohydrolase 1 gene (DDAH1) is related to asymmetric dimethylarginine (ADMA) levels,but not to endothelium-dependent vasodilation[J]. Vascular Medicine,2013,18(4):192-199. doi: 10.1177/1358863X13496488
[20]	JHannemann J,Zummack J,Hillig J,et al. Association of variability in the DDAH1,DDAH2,AGXT2 and PRMT1 genes with circulating ADMA concentration in human whole blood[J]. Journal of Clinical Medicine,2022,11(4):941. doi: 10.3390/jcm11040941
[21]	Zhu F S,Zhou C,Wen Z,et al. DDAH1 promoter -396 4N insertion variant is associated with increased risk of type 2 diabetes in a gender‐dependent manner[J]. Molecular Genetics & Genomic Medicine,2020,8(1):e1011.
[22]	Wang S Y,Deng Z X,Zhang H,et al. The effect of haptoglobin genotype on the association of asymmetric dimethylarginine and DDAH 1 polymorphism with diabetic macroangiopathy[J]. Cardiovascular Diabetology,2022,21:265. doi: 10.1186/s12933-022-01702-6

Relative Articles(20)

Relative Articles

[1]	Xinlin ZHU, Yanan WU, Qi MENG, Qianzi YANG, Yuanbiao LI, Junheng TAO, Mengyang HE. Influence of Medication Compliance of Type 2 Diabetes Chronic Disease Management Patients in Two Communities of Kunming on Disease Control. Journal of Kunming Medical University, 2024, 45(3): 79-83. doi: 10.12259/j.issn.2095-610X.S20240312
[2]	Ling NIU, Rong MA, Cheng ZHANG, Cuijuan MIAO, Yan TANG, Fang LIU, Boyi LI. Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis. Journal of Kunming Medical University, 2024, 45(6): 106-112. doi: 10.12259/j.issn.2095-610X.S20240614
[3]	Boyi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cuijuan MIAO, Cheng ZHANG, Zhujun HAN. The Relationship Between T950C Polymorphism in the Promoter Region of Osteoprotegerin Gene and Type 2 Diabetes with Osteoporosis. Journal of Kunming Medical University, 2022, 43(3): 67-73. doi: 10.12259/j.issn.2095-610X.S20220306
[4]	Ling NIU, Bo-yi LI, Jing-qiu MAO, Yan TANG, Rong MA, Fang LIU, Chen ZHANG, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. The Relationship between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 42(7): 70-76. doi: 10.12259/j.issn.2095-610X.S20210711
[5]	Bo-yi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cui-juan MIAO, Zhu-jun HAN, Cheng ZHANG. The Relationship between T950C Polymorphism in the Promoter Region of Osteoprotegerin Gene and Type 2 Diabetes with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 43(): 1-8. doi: 10.12259/j.issn.2095-610X.S20211112
[6]	Bo-yi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cui-juan MIAO, Zhu-jun HAN, Cheng ZHANG. Association between Calcitonin Receptor Gene Polymorphism and Type 2 Diabetes with Osteoporosis in Kunming. Journal of Kunming Medical University, 2021, 42(7): 57-63. doi: 10.12259/j.issn.2095-610X.S20210709
[7]	Li-xuan YAO, Ben NIU, Wei YUE, Wen-lin ZHOU, Ya-ting ZHANG. Correlation Between Hepatitis C Virus Infection and Type 2 Diabetes Mellitus. Journal of Kunming Medical University, 2021, 42(8): 83-89. doi: 10.12259/j.issn.2095-610X.S20210815
[8]	Cong MEI, Xiao-chun WENG, Bao-kun PENG, Sui-jun YAN, Chun LI, Qiong ZHOU, Zhe TANG. Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality. Journal of Kunming Medical University, 2021, 42(3): 135-139. doi: 10.12259/j.issn.2095-610X.S20210332
[9]	Er-shu RUAN, Shuo WANG, Hui SU, Feng-qiong YIN, Zhong-yi QIAN, Jian-yu YANG. Effect of Ginsenoside Rg1 on Renal Protection in Type 2 Diabetic Rats. Journal of Kunming Medical University, 2021, 42(6): 50-55. doi: 10.12259/j.issn.2095-610X.S20210625
[10]	Jie CHEN, Wei-chang GUO, He-jia YIN, Hong-xia YAN, Fan ZHANG, Yao-yi WANG, Hui-fang LI. The Interaction among Gene Polymorphisms of RANTES and Its Receptor CCR5 and Environmental Factors in the Development of T2DM in Kunming Han Nationality. Journal of Kunming Medical University, 2021, 42(6): 38-44. doi: 10.12259/j.issn.2095-610X.S20210606
[11]	Ling NIU, Bo-yi LI, Cheng ZHANG, Rong MA, Yan TANG, Fang LIU, Li-min YIN, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. Relationship between Calcitonin Receptor，Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 42(11): 74-80. doi: 10.12259/j.issn.2095-610X.S20211114
[12]	Li Jia Li , Zhou Xiao Wei , Guo Wei Chang , Chen Jie , Zhang Fan , Li Hui Fang . . Journal of Kunming Medical University, 2020, 41(06): 60-66.
[13]	Zheng Dang . The Efficacy and Safety of Alpha Lipoic Acid Combined with Methycobal for Patients with Type-2 Diabetes Combined with Diabetic Peripheral Neuropathy. Journal of Kunming Medical University,
[14]	Han Wen Ju , Niu Ben , Liang Yun, Duan Xiao Yan , Su Heng , Xue Yuan Ming . The Relationship between Thyroid Hormone and Purine Metabolism and Body Weight in Patients with Type II Diabetes and Normal Thyroid Function. Journal of Kunming Medical University, 2016, 37(11): 82-85.
[15]	Nian Xin . Difference of Metallothionein Gene G-201A Polymorphism in Type 2 Diabetes and Essential Hypertension. Journal of Kunming Medical University,
[16]	Zhang Wei . Meta Analysis of ADAM33 T1，S2 Polymorphism and the Susceptibility of Bronchial Asthma in China. Journal of Kunming Medical University,
[17]	Deng De Yao . . Journal of Kunming Medical University,
[18]	Nian Xin . The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol. Journal of Kunming Medical University, 2012, 33(02): 1-1.
[19]	Wang Yan . . Journal of Kunming Medical University,
[20]	Li Mei Rui . . Journal of Kunming Medical University,