Single-cell RNA Sequencing: A New Perspective in the Study of Chronic Obstructive Pulmonary Disease

Menghuan LI; Li AI; Yongxia LI

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Menghuan LI, Li AI, Yongxia LI. Single-cell RNA Sequencing: A New Perspective in the Study of Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University.

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Menghuan LI, Li AI, Yongxia LI. Single-cell RNA Sequencing: A New Perspective in the Study of Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University.

Menghuan LI, Li AI, Yongxia LI. Single-cell RNA Sequencing: A New Perspective in the Study of Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University.

Citation:

Menghuan LI, Li AI, Yongxia LI. Single-cell RNA Sequencing: A New Perspective in the Study of Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University.

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Single-cell RNA Sequencing: A New Perspective in the Study of Chronic Obstructive Pulmonary Disease

Department of Respiratory and Critical Care Medicine，The Second Affiliated Hospital of Kunming Medical Univercity，Kunming Yunnan 650101，China

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Corresponding author: 李永霞，女，博士，主任医师，二级教授，昆明医科大学第二附属医院呼吸与危重症医学科二病区科主任，教研室副主任，博士研究生导师。主要从事呼吸疑难危重症、慢阻肺、哮喘、睡眠呼吸紊乱、肺部结节影、呼吸衰竭等呼吸系统疾病诊治。云南省睡眠呼吸紊乱疾病研究中心主任；中国医师协会呼吸分会全国委员；云南肺癌防治协会副会长；云南省医师协会呼吸分会副主任委员；云南省万人计划名医；云南省享受政府特殊津贴人员；云南省中青年学术和技术带头人；昆明市医疗事故鉴定委员会专家库成员。主持多项国家自然科学基金项目（已结题），目前主持省科技厅和省教育厅的科研项目2项，在国内外学术刊物上发表学术论文16余篇，授权实用性新型专利1项。
Available Online: 2025-03-20

Abstract

Abstract

Chronic obstructive pulmonary disease （COPD） is a polygenic disease influenced by the interaction of genetic and environmental factors, characterized by persistent airflow limitation and chronic respiratory symptoms. Traditional gene sequencing methods have revealed the genetic basis of COPD but are limited by the average data of cell populations, making it difficult to fully display the complexity of the disease. Single-cell RNA sequencing technology provides a new perspective, allowing researchers to analyze gene expression at the individual cell level, revealing cellular heterogeneity, which is of great significance for understanding the pathological process of COPD, discovering biomarkers, and personalized medicine. This article reviews the principles of single-cell sequencing technology and its application in COPD research.
- Single-cell RNA sequencing,
- Chronic obstructive pulmonary disease,
- Cellular heterogeneity,
- Pathogenesis,
- Clinical application

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References(38)

References

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