Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer

Shiguo LI; Shulan JIAO

doi:10.12259/j.issn.2095-610X.S20220308

Volume 43 Issue 3

Mar. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(3): 98-102

Shiguo LI, Shulan JIAO. Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer[J]. Journal of Kunming Medical University, 2022, 43(3): 98-102. doi: 10.12259/j.issn.2095-610X.S20220308

Citation:

Shiguo LI, Shulan JIAO. Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer[J]. Journal of Kunming Medical University, 2022, 43(3): 98-102. doi: 10.12259/j.issn.2095-610X.S20220308

Citation:

Shiguo LI, Shulan JIAO. Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer[J]. Journal of Kunming Medical University, 2022, 43(3): 98-102. doi: 10.12259/j.issn.2095-610X.S20220308

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Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer

doi: 10.12259/j.issn.2095-610X.S20220308

Shiguo LI^1
,,
Shulan JIAO²

1.
Dept. of Anesthesiology，Medical Center Hospital Of Qionglai City，Chengdu Sichuan 611500
2.
Dept. of Anesthesiology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2022-01-18
Available Online: 2022-02-18
Publish Date: 2022-03-22

Abstract

Abstract

Objective To compare the effects of hydromorphone and sufentanil on early postoperative cognitive function in patients with colorectal cancer. Methods Eighty-five patients with selective radical resection of colorectal cancerr （including laparoscopic surgery or open surgery） were randomly divided into hydromorphone group of 44 （H group） and sufentanil group of 41 （S group） by random number table method. Postoperative H group was treated with hydromorphone for intravenous analgesia. Group S was treated with sufentanil for intravenous analgesia. Visual analogue score （VAS） was recorded at 6, 12, 24, 48 h after surgery. The adverse reactions such as nausea, vomiting, skin itching, respiratory inhibition, hypotension and dizziness occurred within 48 hours after the operation were observed. Ramsay sedation score was recorded 24 hours after surgery. Mini-Mental State Examination （MMSE） scores were recorded at 1, 2, 3 d after the operation were recorded. Results There was no significant difference in postoperative VAS scores between the two groups （P > 0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups within 48 hours after surgery （P > 0.05）. There was no statistically significant difference in Ramsay sedation score at 24h after surgery between the two groups （P > 0.05）. There was a statistical difference in the postoperative MMSE score between the two groups （P < 0.05）. The incidence of postoperative cognitive dysfunction （POCD） in group H was 15.9% （7/44）, and group S 39% （16/41）. There was a statistical difference in the incidence of POCD between the two groups （P < 0.05）. The grouping factor was an independent one affecting the occurrence of POCD （OR = 3.307, P < 0.05）. Conclusions Hydromorphone and sufentanil are both safe and effective for intravenous controlled analgesia in patients after radical resection of colorectal cancer with no difference in analgesia. Compared with sufentanil, hydromorphone can significantly improve the cognitive impairment of patients after radical colon cancer.
- Hydromorphone,
- Sufentanil,
- Postoperative cognitive dysfunction,
- Patient-controlled intravenous analgesia

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References(17)

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