Abstract: Objective To observe the incidence of secondary epilepsy in patients with cerebral infarction and explore the risk factors of secondary epilepsy. Me thods Eighty-four patients with secondary epilepsy diagnosed as cerebral infarction from April 2016 to August 2017 in our hospital were selected as the observation group, and 84 patients of cerebral infarction without epilepsy in the same period were selected as the control group. Follow-up of secondary epileptic seizures, the general information of patients, basic diseases, hypertension grade, blood electrolytes, lesion location, diameter of lesion were recorded, and the risk factors of secondary epilepsy in cerebral infarction were screened, and the status of secondary epilepsy were analyzed. Re s ults (1) The types of epilepsy in secondary epilepsy: partial seizure in 69 cases, complete attack in 15 cases; onset time: early onset in 60 cases, late in 24 cases. (2) There was no significant difference between the two groups in general information, underlying disease, lesion diameter and grade ofhypertension (P>0.05) . The differences statistically significento significance in the consist of lesion location and lesion specific location and blood electrolyte levels (P <0.05) .Unconditional multivariate logistic regression analysis showed thoao infarction involving the cortex, temporal lobe, and serum chloride value was correlated with the occurrence of secondary epilepsy (P<0.05) . (3) MultivariateLogistic regression analysis showed tthat infaretion involving the cortex (OR = 3.10, P = 0.004, 95% CI =1.52-7.41) , locating in the temporal lobe, (OR = 2.98, P = 0.012, 95% CI = 1.32-7.35) and serum chlorine (OR = 1.25, P = 0.017, 95% CI = 1.00-1.38) were the risk factors for secondary epilepsy in cerebral infarction.Conclusions Partial and early onset of seizures are the most common in cerebral infarction secondary epilepsy.Infarction involving the cortex, locating in the temporal lobe and serum chlorine are the risk factors for secondary epilepsy in patients with cerebral infarction. Necessary measures should be taken to intervene at high risk of secondary epilepsy and to improve the clinical quality of life of patients.