Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance

Gang LI; Jin-song LI; Nan XIE; Chun-mang LI; Lei WEI; Fan CAO; Ying-zhen SU

doi:10.12259/j.issn.2095-610X.S20210415

Volume 42 Issue 4

Apr. 2021

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Gang LI, Jin-song LI, Nan XIE, Chun-mang LI, Lei WEI, Fan CAO, Ying-zhen SU. Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(4): 78-83. doi: 10.12259/j.issn.2095-610X.S20210415

Citation:

Gang LI, Jin-song LI, Nan XIE, Chun-mang LI, Lei WEI, Fan CAO, Ying-zhen SU. Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(4): 78-83. doi: 10.12259/j.issn.2095-610X.S20210415

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Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance

doi: 10.12259/j.issn.2095-610X.S20210415

1.
Dept. of Hepatobiliary Surgery，Cancer Hospital of Chengdu Medical College，The Seventh People’s Hospital of Chengdu，Chengdu Sichuan 610000
2.
The 4th Area，Dept. of Hepatobiliary and Pancreas Surgery，The Second Affiliated Hospital of Kunming Medical University ，Kunming Yunnan 650101
3.
Dept. of Laboratory Science and Preventive Medicine，Kunming University，Kunming Yunnan 650214，China

Received Date: 2021-01-08
Publish Date: 2021-04-01

Abstract

Abstract

Objective To investigate the expression of costimulatory molecule B7-H4 in intrahepatic cholangiocarcinoma （ICC）and its clinical significance. Methods Immunohistochemistry was used to detect the expression of B7-H4 in 90 cases of intrahepatic cholangiocarcinoma and its adjacent tissues, and analyzed the correlation between B7-H4 expression and the clinicopathological characteristics and prognosis of the patients. Results The expression rate of B7-H4 in intrahepatic cholangiocarcinoma was 44.4%, which was significantly higher than that of adjacent tissues. The increased expression of B7-H4 in intrahepatic cholangiocarcinoma was related to TNM staging, tumor differentiation, lymph node metastasis and poor prognosis （P < 0.05）. Survival analysis revealed that the overall survival rate of patients in the B7-H4 high expression group was significantly lower than that in the B7-H4 low expression group （P = 0.005）. Cox proportional hazards regression model analysis showed that B7-H4 is an independent prognostic factor for patients with intrahepatic cholangiocarcinoma. Conclusion The expression of B7-H4 is increased in intrahepatic cholangiocarcinoma tissues, and the high expression of B7-H4 is closely related to the malignant pathological characteristics and poor prognosis of ICC patients, which has clinical guiding significance for predicting the prognosis of patients.
- Co-stimulatory molecule B7-H4,
- Intrahepatic cholangiocarcinoma,
- Pathology,
- Prognosis

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References(21)

References

[1]	胡明,魏雷,谢楠,等. B7-H4与肿瘤发生、发展关系的研究进展[J]. 医学综述,2017,23(14):2760-2764. doi: 10.3969/j.issn.1006-2084.2017.14.012
[2]	Xie N,Cai J B,Zhang L,et al. Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma.[J]. Cell Death & Disease,2017,8(12):3205.
[3]	Cai J B,Shi G M,Dong Z R,et al. Ubiquitin-specific protease 7 accelerates p14(ARF)degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression[J]. Hepatology,2015,61(5):1603-1614. doi: 10.1002/hep.27682
[4]	Sica G L,Choi I H,Zhu G,et al. B7-H4,a molecule of the B7 family,negatively regulates T cell immunity[J]. Immunity,2003,18(6):849-861. doi: 10.1016/S1074-7613(03)00152-3
[5]	刘光艺,黄镇,王子卫. 第8版国际抗癌联盟和美国癌症联合委员会胃癌TNM分期系统简介及解读[J]. 腹部外科,2017,30(4):241-245. doi: 10.3969/j.issn.1003-5591.2017.04.002
[6]	Qian Y,Hong B,Shen L,et al. B7-H4 enhances oncogenicity and inhibits apoptosis in pancreatic cancer cells.[J]. Cell & Tissue Research,2013,353(1):139-151.
[7]	Chen Y,Guo G,Guo S,et al. Intracellular B7-H4 suppresses bile duct epithelial cell apoptosis in human primary biliary cirrhosis[J]. Inflammation,2011,34(6):688-697. doi: 10.1007/s10753-010-9280-6
[8]	Zhang L,Wu H,Lu D,et al. The costimulatory molecule B7-H4 promote tumor progression and cell proliferation through translocating into nucleus[J]. Oncogene,2013,32(46):5347. doi: 10.1038/onc.2012.600
[9]	Jeon Y K,Park S G,Choi I W,et al. Cancer cell-associated cytoplasmic B7-H4 is induced by hypoxia through hypoxia-inducible factor-1α and promotes cancer cell proliferation[J]. Biochem Biophys Res Commun,2015,459(2):277-283. doi: 10.1016/j.bbrc.2015.02.098
[10]	Cui L,Gao B O,Cao Z,et al. Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide[J]. Molecular Medicine Reports,2016,13(3):2032-2038. doi: 10.3892/mmr.2016.4757
[11]	Peng H,Wu W,Yang D,et al. Role of B7-H4 siRNA in proliferation,migration,and invasion of LOVO colorectal carcinoma cell line[J]. Biomed Research International,2015,2015(12):326981.
[12]	Chen X,Wang L,Wang W,et al. B7-H4 facilitates proliferation of esophageal squamous cell carcinoma cells through promoting IL-6/STAT3 pathway activation[J]. Cancer Science,2016,107(7):944-954. doi: 10.1111/cas.12949
[13]	宋慧,谢炜,练启慧,等. PI3K/AKT信号通路的抑制促进B7-H4分子的核转移[J]. 细胞与分子免疫学杂志,2014,30(11):1121-1124.
[14]	Kang Q,Zou H,Yang X,et al. Characterization and prognostic significance of mortalin,Bcl-2 and Bax in intrahepatic cholangiocarcinoma[J]. Oncol Lett,2018,15(2):2161-2168.
[15]	Ke A W,Shi G M,Zhou J,et al. Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma[J]. Hepatology ,2009,49(2):491-503. doi: 10.1002/hep.22639
[16]	Ke A W,Zhang P F,Shen Y H,et al. Generation and characterization of a tetraspanin CD151/integrin alpha6beta1-binding domain competitively binding monoclonal antibody for inhibition of tumor progression in HCC[J]. Oncotarget ,2016,7(5):6314-6322. doi: 10.18632/oncotarget.6833
[17]	Zhang C,Liu L X,Dong Z R,et al. Up-regulation of 14-3-3zeta expression in intrahepatic cholangiocarcinoma and its clinical implications[J]. Tumour Biol,2015,36(3):1781-1789. doi: 10.1007/s13277-014-2780-5
[18]	Yao Y,Ye H,Qi Z,et al. B7-H4(B7x)-mediated cross-talk between glioma-initiating cells and macrophages via the IL6/JAK/STAT3 pathway lead to poor prognosis in glioma patients[J]. Clin Cancer Res,2016,22(11):2778-2790. doi: 10.1158/1078-0432.CCR-15-0858
[19]	Liu L Z,He Y Z,Dong P P,et al. Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway[J]. Oncotrget ,2016,7(46):75210-75220. doi: 10.18632/oncotarget.12116
[20]	Smith J J,Deane N G,Wu F,et al. Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer[J]. Gastroenterology ,2010,138(3):958-968. doi: 10.1053/j.gastro.2009.11.005
[21]	Lan Z,Fu D,Xi M. Serum B7 homologous body 4 for the diagnosis of ovarian cancer in Chinese Han women:A meta-analysis[J]. J Cancer Res Ther ,2018,14(9):433-436. doi: 10.4103/0973-1482.177216