Clinical Significance of C Reactive Protein and Procalcitonin Detection in Neonatal ABO Hemolytic Jaundice

Tuan LI; Yu’e ZHOU; Li MA; Gui LIAO

doi:10.12259/j.issn.2095-610X.S20230122

Volume 44 Issue 1

Jan. 2023

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Tuan LI, Yu’e ZHOU, Li MA, Gui LIAO. Clinical Significance of C Reactive Protein and Procalcitonin Detection in Neonatal ABO Hemolytic Jaundice[J]. Journal of Kunming Medical University, 2023, 44(1): 80-84. doi: 10.12259/j.issn.2095-610X.S20230122

Siqi LI, Wenlin TAI. Significance of CXCL10 as a Biomarker of Liver Cirrhosis[J]. Journal of Kunming Medical University, 2022, 43(7): 55-61. doi: 10.12259/j.issn.2095-610X.S20220711

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Clinical Significance of C Reactive Protein and Procalcitonin Detection in Neonatal ABO Hemolytic Jaundice

doi: 10.12259/j.issn.2095-610X.S20230122

Tuan LI¹,
Yu’e ZHOU^{2
,
,},
Li MA¹,
Gui LIAO²

1.
School of Nursing，Yunnan University of Traditional Chinese Medicine ，Kunming Yunnan 650504
2.
Dept. of Paediatrics，The 3rd People’s Hospital of Yunnan Province， Kunming Yunnan 650011，China

Received Date: 2022-10-13
Available Online: 2022-12-23
Publish Date: 2023-01-18

Abstract

Abstract

Objective To investigate the clinical significance of c reactive protein and procalcitonin levels in neonatal ABO hemolytic jaundice . Methods A total of 50 ABO hemolytic jaundice neonates admitted to a grade III and class A hospital in Yunnan Province between September 2021and August 2022 were selected as the observation group and 53 newborns with non hemolytic and pathological jaundice were selected as the control group during the same period. Retrospective analysis was used to compare the levels of CRP and PCT, abnormal value detection rate and infection rate between the two groups. Results The levels of CRP [11.0000 （9.1750, 13.0025）], PCT [0.6750 （0.3175, 2.9025）], the detection rate of CRP abnormal value （80%）, the detection rate of PCT abnormal value （66%） and the incidence of infection （34%） in the observation group were higher than those in the control group [1.5000 （0.7000, 7.5000）, PCT level [0.3200 （0.2000, 0.5850）], CRP abnormal value detection rate （41.5%）, PCT abnormal value detection rate （32.1%） and infection incidence rate （11.3%）]. The differences were statistically significant （P < 0.05）. The area under the curve （AUC） of CRP in the diagnosis of neonatal progression was 0.664, the sensitivity was 91.3%, and the specificity was 46.2%. PCT had an AUC of 0.711, a sensitivity of 82.6%, and a specificity of 60.0%. Conclusion CRP and PCT can be significantly elevated in the early stage of neonatal ABO hemolytic jaundice, and its detection can detect the progress of the condition as early as possible, ensure the effectiveness of treatment and nursing measures taken in time in clinical practices, and have the great significance in promoting the early rehabilitation of newborns.
- ABO hemolytic jaundice,
- C reactive protein,
- Procalcitonin,
- Newborn

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