A Study of the Level Expression and Clinical Efficacy of Noninvasive Mechanical Ventilation in the Treatment of Insulin-like Growth Factor Ⅰ, Ⅱ and Cathepsin B in Patients with Chronic Obstructive Pulmonary Disease

Huang Li; Huang Xian Xiang

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(08): 74-79

Huang Li , Huang Xian Xiang . A Study of the Level Expression and Clinical Efficacy of Noninvasive Mechanical Ventilation in the Treatment of Insulin-like Growth Factor Ⅰ, Ⅱ and Cathepsin B in Patients with Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University, 2018, 39(08): 74-79.

Citation:

Huang Li , Huang Xian Xiang . A Study of the Level Expression and Clinical Efficacy of Noninvasive Mechanical Ventilation in the Treatment of Insulin-like Growth Factor Ⅰ, Ⅱ and Cathepsin B in Patients with Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University, 2018, 39(08): 74-79.

Citation:

Huang Li , Huang Xian Xiang . A Study of the Level Expression and Clinical Efficacy of Noninvasive Mechanical Ventilation in the Treatment of Insulin-like Growth Factor Ⅰ, Ⅱ and Cathepsin B in Patients with Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University, 2018, 39(08): 74-79.

PDF( 247 KB)

A Study of the Level Expression and Clinical Efficacy of Noninvasive Mechanical Ventilation in the Treatment of Insulin-like Growth Factor Ⅰ, Ⅱ and Cathepsin B in Patients with Chronic Obstructive Pulmonary Disease

Huang Li ¹,
Huang Xian Xiang ²

Funds:

基金：四川省卫生和计划生育委员会科研基金资助项目 (2016-PJ011);

Received Date: 2018-02-21

Abstract

Abstract

Objective To investigate the clinical effect of noninvasive mechanical ventilation in the treatment of chronic obstructive pulmonary disease (COPD) and the expression of insulin-like growth factor (IGF) Ⅰ, Ⅱand cathepsin B (CB) in patients.Methods 89 patients with chronic obstructive pulmonary disease from January2014 to June 2017 in the hospital for treatment were retrospectively chosen as the research objects. They were randomly divided into the control group (n = 43) and the study group (n = 46) . The control group was treated with conventional therapy. The study group was treated with noninvasive mechanical ventilation on the basis of the control group. The observation period was 10 days of treatment, the level of the indicators of lung function, arterial blood gas changes of the both groups were detected, and the clinical treatment efficiency was taken for statistics. At the same time, the levels of IGF-Ⅰ, Ⅱ and CB in patients were analyzed.Results (1) The lung function of the study group: the lung function VC [ (302.72 ± 40.79) m L], the maximum expiratory flow PEF (421.72 ± 37.59) L/min], and the first expiratory volume FEV1 [ (83.24 ± 11.65) %], were significantly higher than that of the control group (P<0.05) . (2) The arterial blood gas in the study group: arterial oxygen partial pressure (PaO2) [ (99.24 ± 10.16) mm Hg], partial pressure of carbon dioxide (PaCO2) [ (43.32 ± 5.37) mm Hg], oxygenation index (PaO2/FiO2) [ (281.02 ± 19.74) % ], were better than the level of detection in the control group (P<0.05) . (3) The effective rate of clinical treatment was 93.48% in the study group, which was significantly higher than that in the control group of 67.44% (P<0.05) . (4) The IGF-Ⅰ [ (11.47 ± 1.53) ug/L] and IGF-Ⅱ [ (28.27± 11.49) ug/L] in the study group were lower than those in the control group, while CB [ (1.03 ± 0.24) ng/ml]was higher than that of the control group (P<0.05) .Conclusions Noninvasive mechanical ventilation is helpful to clear the recovery of lung function in patients with chronic obstructive pulmonary disease, can alter the abnormal expression of insulin-like growth factor I, II and cathepsin B levels in patients, and the clinical treatment effect is significant.
- Chronic obstructive pulmonary disease,
- Noninvasive mechanical ventilation,
- IGF-Ⅰ、Ⅱ,
- CB

FullText(HTML)

References(20)

References

[1]蔡柏蔷.慢性阻塞性肺疾病诊断、处理和预防全球策略 (2011年修订版) 介绍[J].中国呼吸与危重监护杂志, 2012, 11 (1) :1-12.
[2]朱洁, 马啸, 李泽庚, 等.COPD气道重塑与炎症作用机制的研究进展[J].中华中医药学刊, 2015, 34 (3) :546-548.
[3]	[3]FENG E, WAN R, YANG S, et al.Expression levels of induced sputum IL-8 and IL-10 and drug intervention effects in patients with acute exacerbated COPD complicated with chronic corpulmonale athigh altitude[J].Exp Ther Med, 2013, 6 (3) :747-752.
[4] 吴波.无创机械通气治疗慢性阻塞性肺疾病合并呼吸衰竭稳定期的临床研究[J].国际呼吸杂志, 2013, 33 (3) :185-187.
[5]张维.慢性阻塞性肺疾病肺康复治疗新进展[J].实用医院临床杂志, 2012, 9 (5) :222-225.
[6]林晓军, 陈淼, 曾红科, 等.无创正压通气治疗急性左心力衰竭并呼吸衰竭的疗效观察[J].实用医院临床杂志, 2013, 10 (3) :83-84.
[7]李德鹏.无创正压通气在COPD急性加重期呼吸衰竭治疗中的作用[J].海南医学院学报, 2016, 22 (9) :892-894.
[8]	[8]ALTINKAYNAK K, BILICI M, BAKAN N, et al.Circulating levels of IGF-I and IGFBP-3 in gastric cancer[J].Turkish Journal of Medical Sciences, 2012, 42 (9) :1458-1462.
[9] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南 (2013年修订版) [J].中华结核和呼吸杂志, 2013, 36 (4) :255-264.
[10]侯景玉.两种通气模式对慢性阻塞性肺部疾病合并呼吸衰竭周围循环和血气分析的影响[J].中国临床药理学杂志, 2013, 29 (3) :172.
[11]李鹏飞, 安福成, 台娜.无创性目标潮气量机械通气治疗慢性阻塞性肺疾病合并急性II型呼吸衰竭临床观察[J].实用医院临床杂志, 2015, 12 (1) :89-90.
[12]赵华琴.有创机械通气实施时机对COPD急性发作期合并重度呼吸衰竭患者临床疗效的影响[J].检验医学与临床, 2016, 13 (6) :789.
[13]	[13]ZIELINSKI M, CZAJKOWSKI W, GWOZDZ P, et al.Resection of thymomaswith use of the new minimallyinvasive technique of extendedthymectomy performed through the subxiphoid-right video-thoracoscopic approach with double elevation of the sternum[J].Eur J Cardiotorac Surg, 2013, 44 (2) :113-119.
[14]申潞璐, 宋亚茹, 赵卉, 等.胰岛素样生长因子及组织蛋白酶B在慢性阻塞性肺疾病患者血浆中的表达及临床意义[J].当代医学, 2012, 18 (7) :112-113.
[15]邱勤, 李小惠, 陈红.早期应用无创正压通气治疗慢性阻塞性肺疾病急性加重合并呼吸衰竭疗效观察[J].实用医院临床杂志, 2013, 10 (4) :130-132.
[16]	[16]TIAN L.IGF-1 promotes the growth and metastasis of hepatocellularcarcinoma via the inhibition of proteasome-mediated cathepsin B degradation[J].World Journal of Gastroenterology, 2015, 21 (35) :10137-10149.
[17]李雪.COPD患者血液中组织蛋白酶B和胰岛素样生长因子的观察结果分析[J].临床肺科杂志, 2014, 18 (8) :1441-1443.
[18]李毅.胰岛素生长因子与组织蛋白酶B在慢性阻塞性肺疾病患者血液中的表达水平及其临床意义[J].实用医院临床杂志, 2016, 13 (4) :158-159.
[19]李威, 林盪, 陈燕明, 等.无创性目标潮气量机械通气治疗COPD伴重度CO2潴留的疗效观察[J].临床肺科杂志, 2013, 18 (1) :71-72.
[20]邱淑佳.有创-无创序贯机械通气与单纯有创机械通气治疗慢性阻塞性肺疾病并肺源性心脏病伴Ⅱ型呼吸衰竭的临床效果比较[J].实用心脑肺血管病杂志, 2015, 23 (12) :77-78.

Relative Articles(20)

Relative Articles

[1]	Junjun ZHANG, Zhen LIANG, Yanfang PENG. Evaluation Value of AKT/mTOR Signaling Pathway Expression in Peripheral Blood Mononuclear Cells in Patients with Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2026, 47(6): 93-100. doi: 10.12259/j.issn.2095-610X.S20260610
[2]	Yushan TANG, Liuhui ZHANG, Yang WAN. Construction and Validation of a Nomogram for Predicting the Risk of Delirium in Patients with Acute Exacerbation of COPD Complicated by Respiratory Failure. Journal of Kunming Medical University, 2026, 47(6): 1-10.
[3]	Menghuan LI, Li AI, Yongxia LI. Single-cell RNA Sequencing: A New Perspective in the Study of Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2025, 46(3): 1-6. doi: 10.12259/j.issn.2095-610X.S20250301
[4]	Su ZHANG, Zheng HUANG, Na LI, Jing XU, Yiting TAO. A Two Sample Mendelian Randomization Study on Nut Intake and Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2024, 45(11): 81-86. doi: 10.12259/j.issn.2095-610X.S20241112
[5]	Wei MA, Meihua LI, Jing JIANG, Xingxu LIU, Lifen YANG, Li LI. Advances in the study of heparin-binding protein and serum amyloid A in AECOPD co-infection of the lung. Journal of Kunming Medical University, 2023, 44(2): 172-176. doi: 10.12259/j.issn.2095-610X.S20230228
[6]	Jinmei LU, Yuzhu LI, Lin WANG, Xin SU, Jinxiu LIN, Jianhui ZHANG. Study on the Effectiveness of Wearable Device-based Lung Rehabilitation in Patients with COPD. Journal of Kunming Medical University, 2023, 44(11): 175-182. doi: 10.12259/j.issn.2095-610X.S20231127
[7]	Ye Xiu Lin , Yang Jiao , Li Min , Fang Yan , Tian Xi , Zhu Wen Zhuo . . Journal of Kunming Medical University, 2020, 41(02): 43-48.
[8]	He-ping LIU, Hong-mei WU, Yang LIU, Chun ZHANG, Wei-zhou WANG, Ding-yun YOU, Hong-xiang WU. Correlation between Anxiety Depression Symptoms of Patients with Chronic Obstructive Pulmonary Disease and CAT Score. Journal of Kunming Medical University, 2020, 41(12): 29-35. doi: 10.12259/j.issn.2095-610X.S20201212
[9]	Sun Shi Bo , Luo Zhuang , Du Xiao Hua , Yang Jiao , Ye Xiu Lin , Zhang Dong Xian , Yang Wei Min . . Journal of Kunming Medical University, 2019, 40(06): 109-113.
[10]	Yang Xia , Feng Mei , Wu Ying , Zhu Jing . . Journal of Kunming Medical University, 2019, 40(08): 83-87.
[11]	Liu Jian Hong , Zhou Ji Bo . . Journal of Kunming Medical University, 2017, 38(03): 39-42.
[12]	Lai 碁. The Application Time of NIMV Treatment in ACS Patients with Hypoxaemia. Journal of Kunming Medical University,
[13]	Bi Hong . The Analysis of Influential Factors of Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease in Kunming. Journal of Kunming Medical University,
[14]	Zeng Hai Ping . . Journal of Kunming Medical University,
[15]	Yang Huan Zhi . . Journal of Kunming Medical University,
[16]	Dong Yu . . Journal of Kunming Medical University,
[17]	Wang Zhu Jun . . Journal of Kunming Medical University,
[18]	Liu Shi Chang . . Journal of Kunming Medical University,
[19]	Wang Xin . . Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,