重组人血管内皮抑制素联合放化疗治疗局部晚期头颈部鳞癌

尚艺泰; 杨洁; 李磊; 李晓江

重组人血管内皮抑制素联合放化疗治疗局部晚期头颈部鳞癌

昆明医科大学第三附属医院头颈外科云南省头颈外科

基金项目:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2014FZ037);

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出版历程
- 收稿日期: 2017-03-14

Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma by Recombinant Human Vascular Endostatin Combined with Chemoradiotherapy

Funds:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2014FZ037);

摘要

摘要: 目的分析重组人血管内皮抑制素注射液 (恩度) 联合放化疗治疗局部晚期头颈部鳞癌的疗效及安全性.方法收集自2011年7月至2014年6月云南省肿瘤医院收治的局部晚期头颈部鳞癌患者病例资料.放化疗联合恩度组 (恩度组) 有46例患者, 放化疗组 (对照组) 有45例患者.分析比较2组近期疗效及毒副反应比, 总生存率 (OS) 、无疾病进展期 (PFS) .采用美国华盛顿大学生活质量评估比较2组生活质量.结果恩度组与对照组客观反应率分别为87.0%和75.6% (χ2=1.946, P>0.05) , 疾病控制率分别为97.8%和95.6% (χ2=0.368, P>0.05) .恩度组与对照组的中位PFS分别为18.7月和14.7月 (P<0.05) , 中位OS分别为26.8月和23.6月 (P>0.05) , 恩度组与对照组各项不良反应发生率相近.恩度组生活质量评估在心情、焦虑、总分方面高于对照组, 差异有统计学意义 (P<0.05) .结论恩度联合放化疗治疗局部晚期头颈部鳞癌过程中, 在一定程度上增加疗效, 延长了无疾病进展期, 同时不增加不良反应发生率, 提高一定生活质量, 但对于患者的生存期获益仍需进一步研究.
- 头颈部肿瘤 /
- 血管生成抑制剂 /
- 内皮抑素类
Abstract: Objective To analyze the therapeutic efficacy of chemoradiotherapy combined with recombinant human vascular endostatin (endostar) in the treatment of locally advanced head and neck squamous cell carcinoma.Methods From July 2011 to June 2014, data of the patients with locally advanced head and neck squamous cell carcinomas were collected, including 46 patients with chemoradiotherapy combined with endostar and 45 patients with chemoradiotherapy only and the two groups were divided: endostar groups (46 patients) and control group (45 patients) . Objective response rates, disease control rate, overall survival (OS) , and progress free survival (PFS) were compared. Quality of Life Questionnaire from University of Washington was applied to evaluate the life quality of the two groups. Results The objective response rate of endostar group and control group were 87.0% and 75.6% respectively (χ2=1.946, P>0.05) , disease control rate being 97.8% and 95.6% respectively (χ2=0.368, P>0.05) , the median PFS being 18.7 months and 14.7 months respectively (P<0.05) , and median OS being 26.8 months and 23.6 months respectively (P>0.05) . The adverse reaction rate were similar between the two groups. The scores of quality of life, including mood and anxiety domain and total score, in endostar group were higher than those in control group (P <0.05) . Conclusion Endostar combined with chemoradiotherapy can enhance the therapeutic effect of locally advanced head and neck squamous cell carcinoma, prolong free survival progress, improve the quality of life and does not increase adverse reaction rate. But the survival benefit for patients still needs further study.
- Head and Neck Neoplasms /
- Angiogenesis Inhibitors /
- Endostatin

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参考文献(12)

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