Research Advances in D-dimer/Fibrinogen Ratio and Fibrinogen/Albumin Ratio in Acute Coronary Syndromes
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摘要: 急性冠脉综合征（acute coronary syndromes，ACS）是冠状动脉粥样硬化进程中，不稳定的粥样硬化斑块破裂或糜烂继发新鲜血栓形成所导致的心脏急性缺血综合征。近年来，基于凝血-炎症通路的生物标志物，如血浆D-二聚体/纤维蛋白原比值（D-dimer/fibrinogen ratio，DFR）、纤维蛋白原/白蛋白比值（fibrinogen/albumin ratio，FAR），因其与斑块稳定性、血栓负荷及微血管功能障碍密切相关，成为预测冠脉病变严重程度的研究热点。系统综述了DFR、FAR在ACS患者冠脉病变评估中的机制及临床应用价值，指出DFR、FAR在评估ACS患者的冠脉病变程度，以及为后续制定合理的治疗方案和改善预后等方面的重要意义。
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关键词:
- 急性冠脉综合征 /
- D-二聚体/纤维蛋白原比值 /
- 纤维蛋白原/白蛋白比值 /
- 综述
Abstract: Acute coronary syndrome （ACS） represent a group of acute cardiac ischemic conditions resulting from the rupture or erosion of unstable atherosclerotic plaques in the coronary arteries, leading to fresh thrombus formation. In recent years, biomarkers based on the coagulation-inflammation pathway, such as plasma D-dimer/fibrinogen ratio （DFR） and fibrinogen/albumin ratio （FAR）, have become a hot research topic for predicting the severity of coronary artery disease. This is due to their close correlation with plaque stability, thrombotic burden, and microvascular dysfunction. This review systematically summarizes the mechanism and clinical application value of DFR and FAR in the assessment of coronary lesions in patients with ACS. It highlights the significant roles of DFR and FAR in evaluating the severity of coronary lesions, facilitating the formulation of appropriate treatment strategies, and potentially improving patient prognosis.-
Key words:
- Acute coronary syndromes /
- D-dimer/fibrinogen ratio /
- Fibrinogen/albumin ratio /
- Review
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图 1 DFR、FAR在ACS中的病理生理机制及临床意义示意图
Figure 1. Schematic diagram illustrating the pathophysiological mechanisms and clinical significance of DFR and FAR in ACS
图 2 凝血、纤溶系统示意图
Figure 2. Schematic diagram of the coagulation and fibrinolytic systems
图 3 炎症与营养状态综合反应示意图
Figure 3. Schematic diagram illustrating the integrated response of inflammation and nutritional status
表 1 DFR与ACS病变严重程度相关研究
Table 1. Studies on the correlation between DFR and the severity of ACS lesions
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表 2 FAR与ACS病变严重程度相关研究
Table 2. Studies on the correlation between FAR and the severity of ACS lesions
下载: 导出CSV
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