A Comparative Study of Developmental Trajectories in Term ART and Spontaneously Conceived Infants During Infancy: A Multicenter Investigation Using the Denver Developmental Screening Test
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摘要:
目的 经辅助生殖技术（assisted reproductive technology，ART）足月儿和正常受孕婴儿在6个月和12个月时的发育差异，为辅助生殖技术对婴儿认知发育的健康发展提供科学依据。 方法 采用巢式病例对照研究的方法，对来大连市妇女儿童医疗中心和昆明市妇幼保健院就诊的2023年10月至2024年4月试管婴儿和正常受孕婴儿进行发育情况比较。比较两组在性别、出生孕周、体重、身长、头围等基本人口特征及发育筛查结果，对丹佛发育内容登记，并根据丹佛发育筛查表（denver developmental screening test，DDST）进行综合评价。 结果 两组在基本特征方面差异无统计学意义（P > 0.05），6月龄和12月龄时的精细运动、大运动、语言和社会发育评估差异无统计学意义（P > 0.05）。通过SPSS20.0进行统计分析，DDST总体比较显示两组在早期发育水平上相似（P = 0.957和P = 0.965）。 结论 经ART技术受孕产下的婴儿与同龄的自然受孕婴儿在丹佛发育中的精细动作、大动作、社会发育及语言发育情况基本一致。试管婴儿的早期发育潜力与正常受孕婴儿相当。 Abstract:Objective To investigate the developmental differences between full-term infants born through assisted reproductive technology （ART） and infants conceived naturally at 6 and 12 months of age, in order to provide scientific evidence for the healthy development of infants' cognitive abilities due to assisted reproductive technology. Methods A nested case-control study was conducted to compare the developmental status of infants conceived through ART and those conceived naturally who visited the Women and Children's Medical Center of Dalian and Kunming Maternal and Child Health Hospital from October 2023 to April 2024. The basic demographic characteristics such as gender, gestational age at birth, weight, height, and head circumference, as well as the developmental screening results of both groups were compared. The Denver Developmental Content Record was used for assessment, and a comprehensive evaluation was conducted based on the Denver Developmental Screening Test （DDST）. Results There was no statistically significant difference in basic characteristics between the two groups （P > 0.05）. There was no statistically significant difference in fine motor skills, gross motor skills, language, and social development assessments at 6 months and 12 months （P > 0.05）. Statistical analysis using SPSS 20.0 showed that the overall comparison of DDST indicated that the early developmental levels of the two groups were similar （P = 0.957 and P = 0.965）. Conclusions Infants conceived through ART and those conceived naturally at the same age have basically the same developmental status in terms of fine motor skills, gross motor skills, social development, and language development in the Denver Developmental Assessment. The early developmental potential of infants conceived through ART is comparable to that of naturally conceived infants, reflecting the effectiveness of modern assisted reproductive technologies. -
Key words:
- Assisted reproduction /
- Term infants /
- Denver development
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图 2 精细动作、大运动、社会发育、语言发育比较对比图
Figure 2. Comparison chart of fine motor skills，gross motor skills，social development and language development
表 1 一般资料比较[$\bar x \pm s $，n（%）]
Table 1. General Information Comparison [$\bar x \pm s $，n（%）]
变量 试管婴儿组 正常受孕组 χ2/t P n 32 34 出生孕周 38.4 ± 1.43 38.6 ± 1.35 −0.445 0.658 男 18（56.2） 19（55.9） 0.001 0.976 女 14（43.8） 15（44.1） − − 体重（kg） 3.1 ± 0.59 3.2 ± 0.54 −0.562 0.576 身长（cm） 46.5 ± 4.04 47.1 ± 3.84 0.643 0.522 头围（cm） 32.5 ± 1.34 33.0 ± 1.75 −1.454 0.151 Apgar评分（1 min） 8.9 ± 1.00 8.5 ± 0.99 1.780 0.080 Apgar评分（5 min） 9.6 ± 0.67 9.7 ± 0.57 −1.134 0.261 
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表 2 6月龄、12月龄DDST总体比较[n（%）]
Table 2. Overall comparison of DDST at 6 months and 12 months [n （%）]
组别 n 正常组（%） 可疑组（%） 异常组（%） χ2 P 6月龄 试管婴儿组 32 30（93.8） 2（6.2） 0（0.0） 0.003 0.957 正常受孕组 34 33（97.1） 1（2.9） 0（0.0） 12月龄 试管婴儿组 32 31（96.9） 1（3.1） 0（0.0） 0.002 0.965 正常受孕组 34 33（97.1） 1（2.9） 0（0.0）
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