-
摘要:
目的 研究云南独蒜兰化学成分,发现其活性成分。 方法 云南独蒜兰乙酸乙酯提取、硅胶柱层析和Sephadex LH-20柱层析进行分离纯化，波谱分析（核磁共振氢谱、碳谱、和质谱）确定结构。 结果 从该药用植物乙酸乙酯萃取部分分离并鉴定了5个化合物，分别为：gigantol（1），batatasin III（2），2-methoxy-4,7-dihydroxy-9,10-dihydrophenanthrene（3），2,7-dihydroxy-4-methoxy-9,10-dihydrophenanthrene（4），2,7-dihydroxy-4-methoxyphenanthrene（5）。 结论 化合物5为首次从本植物中分离得到。 Abstract:Objective Study the chemical compounds from the plants of P. yunnanensis and find its bioactive constituents. Methods The compounds were extracted by ethyl acetate and isolated by column chromatography on silica gel and Sephadex LH-20. 1H NMR, 13CNMR and EI-MS were used to elucidate their structure. Results Five compounds including gigantol （1）, batatasin III （2）, 2-methoxy-4,7-dihydroxy-9,10-dihydrophenanthrene （3）, 2,7-dihydroxy-4-methoxy-9,10-dihydro-phenanthrene （4）, 2,7-dihydroxy-4-methoxyphenanthrene （5） were obtained. Conclusion Compound 5 was isolated from the plant for the first time. -
Key words:
- Pleione yunnanensis /
- Phenanthranes /
- Bibenzyls
-
[1] Wang Z X,Zhang H,Chen L,et al. Leaf epidermal micro-morphology and taxonomic significance of 15 species of Pleione[J]. Acta Bot boreal,2020,40(9):1527-1538. [2] Dong H L,Wang C L,Guo S X,et al. Cheminform abstract:New bibenzyl derivatives from the tubers of Pleione yunnanensis[J]. Chemical & Pharmaceutical Bulletin,2010,40(43):513-515. [3] Dong H L,Liang H Q,Wang C L,et al. Shancigusins E-I,five new glucosides from the tubers of Pleione yunnanensis[J]. Magnetic Resonance in Chemistry,2013,51(6):371-377. doi: 10.1002/mrc.3953 [4] Won J H,Kim J Y,Yun K J,et al. Gigantol isolated from the whole plants of cymbidium goeringii inhibits the LPS-induced iNOS and COX-2 expression via NF-kappaB inactivation in RAW 264.7 macrophages cells[J]. Planta Medica,2006,72(13):1181-1187. doi: 10.1055/s-2006-947201 [5] Leong Y W,Kang C C,Harrison LJ,et al. Phenanthrenes,dihydrophenanthrenes and bibenzyls from the orchid Bulbophyllum vaginatum[J]. Phytochemistry,1997,44(1):157-165. doi: 10.1016/S0031-9422(96)00387-1 [6] Lee Y H,Park J D,Baek N I,et al. In-vitro antitumoral phenanthrenes from the aerial parts of Dendrobium nobile[J]. Planta Med,1995,61(2):178-180. doi: 10.1055/s-2006-958043 [7] Shiao Y J,Chen W P,Lin Y L,et al. New polyphenols and triterpene from the Pseudobulbs of Pleione formosana[J]. Journal of the Chinese Chemical Society,2009,56(4):828-833. doi: 10.1002/jccs.200900122 [8] Li B,Masukawa N,YAmaki M,et al. Four stilbenoids from Pleione bulbocodioides[J]. Phytochemistry,1998,48(2):327-331. doi: 10.1016/S0031-9422(97)01110-2 [9] Xin Qiao Liu,Wen Yuan Gao,Yuan Qiang Guo,et al. A new phenanthro [2,3-b] furan from Pleione bulbocodioides[J]. Chinese Chemical Letters,2007(18):1089-1091. [10] Liu X Q,Yuan Q Y. A New fibenzyl from Pleione bulbocodioides[J]. Asian Journal of Chemistry,2013,25(6):3519-3520. doi: 10.14233/ajchem.2013.13794 [11] Shao S Y,Wang C,Han S W,et al. Phenanthrenequinone enantiomers with cytotoxic activities from the tubers of Pleione bulbocodioides[J]. Organic & Biomolecular Chemistry,2019,17(3):567-572. [12] Xin Qiao Liu,Qiao Yu Yuan,Yuan Qiang Guo. A new bibenzyl derivative from Pleione bulbocodioides[J]. Chinese Chemical Letters,2008,19(5):559-561. doi: 10.1016/j.cclet.2008.03.023 [13] Li Bai,Masae Yamaki,Shuzo Takagi. Lignans and a bichroman from Pleione bulbocodioides[J]. Phytochemistry,1997,44(2):341-343. doi: 10.1016/S0031-9422(96)00549-3 -
下载:
点击查看大图
图(1) / 表(1)
计量
- 文章访问数: 2996
- HTML全文浏览量: 2012
- PDF下载量: 18
- 被引次数: 0
