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Supervisor：Education Department of Yunnan Province Sponsor：Kunming Medical University Chief Editor：Xia Xueshan

ISSN 2095-610X CN 53-1221/R

Address：1168 Chunrong West Road, Yuhua street, Chenggong New City, Kunming

Postal Code：650500 Telephone：0871－65936489 

E-mail：kmykdxxbzk@163.com

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Articles just accepted have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
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Relationship Between Serum CD46，KLF7，FURIN and Clinicopathological Features in Patients with Chronic Cervicitis Combined with HPV Infection and Their Prognostic Predictive Value
Zhiying ZHANG, Peijing SHI
Abstract(366) PDF(132)
Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
Display Method:
Construction of An Early Warning Model for Upper Gastrointestinal Bleeding in Patients with Cirrhotic Portal Hypertension Based on Serum miR-140 and miR-335-5p Combined with Clinical Indicators
Li YOU, Ning LI, Yunjun GAO, Yongsheng LI, Yafeng WU, Jiansheng LI
Abstract(46) PDF(6)
Advances in Squalene Epoxidase as A Potential Therapeutic Target in Breast Cancer
Ningxin ZHANG, Li LI, Shan LIU, Jianyun NIE
Abstract(19) PDF(2)
Predictive Value of Combined Detection of IL-10，IFN-γ，PLR，and FIB in Endometrial Lesions
Tianyuan ZHAO, Yanhe CHANG, Xiaoyan NI, Yijun WANG, Xiaoyu LIU, Lijie JIANG
Abstract(95) PDF(38)
Assessment Value of Neonatal Critical Illness Score，Umbilical Cord Blood MIF，and IL-1β in Evaluating Clinical Efficacy of Neonatal Respiratory Distress Syndrome
Yuru DUAN, Yiming WANG, Lei ZHU
 doi: 10.12259/j.issn.2095-610X.S20260000
Abstract(81) HTML PDF(38)
Prediction of Major Adverse Cardiovascular Events Following PCI in NSTEMI Patients Using Combined Myocardial Contrast Echocardiography and Three-dimensional Speckle Tracking Imaging
Ting WEN, Lingjiao ZENG, Ye HUANG, Qingyong QIU, Lingling ZHU
Abstract(95) PDF(36)
Efficacy of Visual Stent Boost-guided Percutaneous Coronary Intervention in Patients with Typical Angina Pectoris and Moderate-to-severe Calcified Lesions
Hongmei CHEN, Zhengbo ZHAO, Yun HU, Jun LI
Abstract(134) PDF(38)
Effects of Erianin on Ferroptosis in Prostate Cancer Cells via the Keap1/Nrf2/HO-1 Signaling Pathway
Haiying ZHAO, Jianrong LIU, Yang XIANG
Abstract(108) PDF(37)
Influencing Factors of First-episode Adolescent Depression with Suicidal Ideation in A Minority Ethnic Concentrated Region in Southern Yunnan
Xinyi DUAN, Xuejiao ZHANG, Xi HOU, Zhengdong NIE, Kang LI, Tingting LI
Abstract(145) PDF(37)
Combined Predictive Value of miR-155 and miR-146a in Peripheral Blood Mononuclear Cells for Assessing Poor Prognosis Risk in Patients with Uremia Undergoing Maintenance Hemodialysis
Xiaojian WANG, Junping LIU, Di ZHANG, Qian GUO
Abstract(80) PDF(38)
Mechanisms of Resveratrol Inhibiting Glycolysis in Glioblastoma Cells through G6PC
Xuetao YI, Hui LI, Yongsheng HE, Yanjun WANG
Abstract(96) PDF(37)
Correlation between T1 Mapping and Feature Tracking in Hypertrophic Cardiomyopathy
Yan ZHANG, Lei YANG, Na LI, Mingjie PANG
Abstract(82) PDF(38)
Effect of Tirofiban on Serum miR-181c and miR-130a Expression in Patients with Acute Ischemic Stroke Following Failed Thrombolysis in the Hyperacute Phase
Jian SUN, Huanhuan WANG, Hongmei HE, Haiyan ZHANG, Qian XUE, Aixia SONG
Abstract(96) PDF(44)
Application of Backward Design Based on OBE Concept in Pathology Teaching
Wenqing SONG, Bo ZHU, Lan YU, Xiaomeng GONG
Abstract(112) PDF(37)
Correlation of Helicobacter pylori Antibody Serotypes，Immune Response，and Gut Microbiota in Children with Abdominal-type Henoch-Schönlein Purpura Presenting with Gastrointestinal Hemorrhage
Junying LIU, Wenhui LI, Xin ZHAO, Weina SHI, Xiaojuan WANG
Abstract(86) PDF(36)
miR-15a and miR-16-1 Combined with MEG3 for Assessing Recurrence Risk in Endometrial Cancer Patients
Zhaoqiang LI, Yingnan HUANG, Junying DU
Abstract(76) PDF(36)
Research Progress and Application Prospects of Neuroglia-associated Exosomes in Schizophrenia
Biyao GAO, Fuyi QIN, Yilin LIU, Jia WEN, Xinrui LI, Yuan FANG, Yunqiao ZHANG
Abstract(111) PDF(43)
miR-6509-3p Regulates EMT Process to Promote Migration and Invasion of Hepatocellular Carcinoma Cells
Shihan CHEN, Quanhui WANG, Lina ZHANG, Kun LI, Chunxu ZHANG
Abstract(107) PDF(47)
DAPK1/MAPK1 Axis Regulates Neuronal Damage in Parkinson's Disease Models
Zhongkun REN, Bibo GAO, Xueling SUN, Lingying ZHU, Yinfang SU
Abstract(93) PDF(37)
Diagnostic Value of Serum SHBG，NCAM and CCL2 Levels in Cognitive Dysfunction in First-episode Patients with Schizophrenia
Zhaogui CHEN, Yanhui MOU, Jingci CHEN, Zhi QUAN, Jingsi CHEN
Abstract(87) PDF(35)
Clinical and Pathological Characteristics of Non-small Cell Lung Cancer with Pleural Effusion at Different Hematocrit Levels and Their Correlation with Prognosis
Ruwei JIANG, Lijun XU, Huiru WANG, Siyu HUANG
Abstract(115) PDF(41)
Body Composition Differences and Influencing Factors in Early Pregnancy between Naxi and Han Ethnic Groups
Junqiang WANG, Limei HE, Jie SONG, Hongjuan HE, Ping HE
Abstract(107) PDF(42)
The Relationship between Peripheral Blood MiR-409-3p，MiR-6861-5p and the Prognosis of TACE in Patients with Hepatocellular Carcinoma
Tong HUANG, Jie HU, Haiting YUAN, Jiahui LI, Wuhua LIN
Abstract(148) PDF(58)
Expression and Clinical Significance of the Endoplasmic Reticulum PERK/eIF-2α Signaling Pathway in Cervical Cancer
Peipei HE, Ke CHEN, Jun XU, Zhixia WANG, Xuemei YAN
Abstract(240) PDF(107)
The Role and Mechanism of Mitochondrial Ferroptosis in Uremic Toxin-associated Myocardial Injury
Yaping ZHOU, Fangfang DI, Wei WANG
Abstract(293) PDF(107)
Evaluation Value of AKT/mTOR Signaling Pathway Expression in Peripheral Blood Mononuclear Cells in Patients with Chronic Obstructive Pulmonary Disease
Junjun ZHANG, Zhen LIANG, Yanfang PENG
Abstract(293) PDF(105)
Genomic Analysis of Two Novel Coxsackievirus B2 Strains in 2022
Xiang LI, Zhaoyang CHU, Hengli YANG, Changzeng FENG, Li LI, Jiansheng LIU, Shaohui MA
Abstract(261) PDF(100)
Correlation Between Serum NF-κB，S1P1，and SOCS3 Levels and Disease Severity in Children with Bacterial Infectious Pneumonia，and Their Prognostic Predictive Value
Mengjiao ZHAO, Yanni JU
Abstract(262) PDF(104)
Molecular Docking-Based Screening and Activity Studies of NDM-1 β-Lactamase Inhibitors against Klebsiella pneumoniae
Xiaoyu YANG, Bo LI, Rui ZHENG, Min SU
Abstract(214) PDF(101)
HIF-2Α Promotes Osteoarthritis Progression by Regulating Articular Cartilage Deg-eneration Through Activation of CXCR4
Peng XU, Yazhou XIAO, Zhengliang LEI, Huan LIU, Luchang LIU
Abstract(364) PDF(96)
Correlation Between Energy Spectrum CT Iodine-Based Values and FEV1/FVC in Early-Stage Small Airway Damage of the Lung
Xiang GAO, Cheng YANG
Abstract(208) PDF(99)
Core Active Substances and Molecular Mechanisms of Traditional Chinese Medicine in Treating IgA Nephropathy Based on Data Mining and Network Pharmacology
Chuanqi YANG, Ruolian ZHAO, Yajuan TANG, Zijie LIU, Huan LI, Hui ZHANG, Lin CHAI
Abstract(860) PDF(105)
Therapeutic Effects of Ultrasound-guided Closed Thoracic Drainage in Patients with Complex and Refractory Pneumothorax and Its Impact on Inflammatory Factors and Pulmonary Function
Dan LIU, Shanglin BAI, Xu WU, Wangsheng REN, Xianyu WU, Hang ZENG, Guo XU
Abstract(401) PDF(94)
Trajectories and Influencing Factors of Cancer-related Anorexia in Nasopharyngeal Carcinoma Patients under Local Hypothermia Care Combined with Nutritional Intervention for Radiation-induced Oral Mucositis
Yaping HU, Peijuan CHEN, Dan LI, Lian. HE
Abstract(250) PDF(96)
Disease Burden of Hypertensive Nephropathy Attributable to High Sodium Diet in China，Japan，and the United States During 1990-2021 and Its Predictive Analysis
Lanxi FANG, Guanlin LIU, Yuhang YANG, Delong ZHAO, Wanchen DAI, Qiong MENG
Abstract(322) PDF(95)
The Burden and Trends of Ischemic Heart Disease Attributable to Low Physical Activity Globally and in China，1990—2021
Changyong WU, Zhongkai WANG, Menghan LI, Bingqing ZHANG, Yihua LUO, Yunzhu PENG
Abstract(428) PDF(111)
Effects of Dexmedetomidine Combined with Sufentanil on Pain Sensitization and Spinal Inflammatory Response in Rats with Incisional Pain
Huizhen GAO, Qingling YANG, Yanan ZHANG, Shujun GAO
Abstract(356) PDF(104)
Awareness of the Core Knowledge of Cancer Prevention and Control in Ethnic Minority Areas of Yunnan，China:A Cross-Sectional Study
Hai ZHOU, Jun HE, Fengjian SA, Sile LI, Yongcun CEN, Jie MA, Yunchao HUANG
Abstract(448) PDF(103)
Propofol Modulates the miR-142-3p/RAC1/NF-κB Axis to Influence Knee Osteoarthritis in Rats
Chengneng FAN, Jintao SHI, Shuangwei LU, Meng YU
Abstract(216) PDF(102)
Correlation and Predictive Value of Serum MiR-155，HBP and AECOPD Treatment Efficacy
Yang LI, Xueting YANG, Liling DING, Jie LONG
Abstract(217) PDF(98)
Application of miR-132，BDNF and NRG-1 in the Diagnosis and Prognosis of AI-related Vascular Dementia
Saibing LIU, Liping YAN, Ani SUN
Abstract(250) PDF(91)
Correlation and Significance of FCN3，IGF-1 and Immune Function in Children with Recurrent Respiratory Tract Infection
Jing LAN, Huaying YANG, Jianhong CHENG
Abstract(315) PDF(97)
Establishment of a Nomogram Model for Predicting Abnormal Bone Mass in Diabetic Patients
Hui LIU, Xinyi PENG, Tonger LIANG, Yong ZHAO
Abstract(342) PDF(93)
Research Progress on Bacteriophage Prevention and Treatment of Dental Caries
Zehua HAN, Xiaoyan YANG, Yuliang CHEN, Xuelin LI, Rongyu YANG, Yingying XIANG
Abstract(324) PDF(95)
Serological Features of Neurological Involvement in ANCA-associated Vasculitis and Their Predictive Value for Prognosis
Chunrong YAO, Danqing HUANG, Yini KE
Abstract(441) PDF(102)
The Prognostic Value of Uterine Artery Blood Flow Combined with Serum Factors for Preeclampsia in Mid-pregnancy
Ruiyan LEI, Huimin HAO, Peiying WANG, Hui SUN, Li ZHANG
Abstract(423) PDF(113)
TMAO Inhibitors' Effects on Diabetic Sarcopenia in Rats
Shuimei LIAN, Qian YANG, Ting WANG
Abstract(351) PDF(115)
Mechanistic Study of the Inhibitory Effects of Hedyotis Diffusa Ethanol Extract on Breast Cancer Cells via Activation of the Cyt-c/Caspase-9-related Mitochondrial Pathway
Xiaoxiao LIAN, Tao HAN, Kunmeng CUI, Yan WANG, Yongfang LIU, Tian GUO, Ruixue YANG, Ya WANG
Abstract(287) PDF(105)
Mechanisms of miR-21-5p in Promoting Osteoarthritis Progression through Inhibition of SIRT2/AKT Signaling Pathway
Xiaotian CHEN, Zhenfei DING, Yining SONG, Banghong JIANG, Fan ZHANG, Yi GAO, Jianzhong GUAN
Abstract(305) PDF(112)
Effects of Sanqi Oral Liquid on Glycolysis，Renal Cell Apoptosis，and Keap1-Nrf2 Signaling Pathway in Diabetic Nephropathy Rats
Wenchao LI, Xue LI, Shanshan LIN, Yun MA, Guorui KANG, Ye CHEN
 doi: 10.12259/j.issn.2095-610X.S20250000
Abstract(555) HTML PDF(93)
Study on the Mechanism by Which GPX4 Expression Promotes Ferroptosis and Participates in Malignant Behavior of Endometrial Carcinoma
Xiaoxia DONG, Shuxian CHEN
Abstract(715) PDF(177)
Molecular Mechanism of the YAP1/ANXA2 Signaling Axis in Regulating Apoptosis and Migration of Renal Tubular Epithelial Cells
Shaoting SUN, Lanmei LI, Weiwei BAI, Na CHEN, Meng WANG, Ming ZHANG, Yafen LI
Abstract(480) PDF(87)
Research Advances in D-dimer/Fibrinogen Ratio and Fibrinogen/Albumin Ratio in Acute Coronary Syndromes
Jizhou LI, Hongwei LI, Ye ZHANG, Hongling YANG
Abstract(594) PDF(96)
Analysis of the Value of Serum Testosterone，Sex Hormone-binding Globulin and Vitamin D Levels in Predicting Gestational Diabetes Mellitus Complicated by Polycystic Ovary Syndrome
Yuzhen ZHAO, Yingyan MA, Lili HE
Abstract(688) PDF(103)
Correlation between Esophageal Manometry and Short-term Efficacy of Endoscopic Myotomy in Patients with Achalasia
Yingye SONG, Juanping LI, Rui LI
Abstract(372) PDF(102)
Efficacy of Butylphthalide Combined with Atorvastatin in the Treatment of Cerebral Infarction and Its Effects on the Expression of vWF，PAI-1 and Ve Cadherin in Vascular Endothelium
Kejiao LI, Zichen LIU, Sha CHANG, Xue SONG, Fang LI
Abstract(561) PDF(74)
Expert Consensus on the Diagnosis and Treatment of Chronic Coronary Syndrome with Traditional Chinese and Western Medicine in Yunnan Province
Li ZHANG, Ying ZHANG, Xueya ZHANG, Zhuo YU
Abstract(797) PDF(90)
Column
Expert Forum
Research Progress of Mesenchymal Stem Cells in the Treatment of Allergic Rhinitis via the Treg-ILC2 Axis
Rui CHEN, Shouming CAO, Haiying WU, Haosu HUANG, Xiaoying ZHOU, Weiyue HAN, Zongcheng JIANG
2026, 47(3): 1-11.    doi: 10.12259/j.issn.2095-610X.S20260301
Abstract(290) HTML PDF(56)
Original Articles Basic of Medicine
Expression and Prognostic Value of WDR62 in Hepatocellular Carcinoma
Fuwei ZHANG, Tao WANG, Tao WU
2026, 47(3): 12-22.    doi: 10.12259/j.issn.2095-610X.S20260302
Abstract(315) HTML PDF(112)
PCK2 Promotes Malignant Phenotypes of Non-Small Cell Lung Cancer Cells via SLC38A2-Mediated Glutamine Uptake
Libo RUAN, Kewang XU, Minjun ZHAO, Fan ZHANG, Wenjun ZENG, Haiyan ZHANG
2026, 47(3): 23-33.    doi: 10.12259/j.issn.2095-610X.S20260303
Abstract(392) HTML PDF(116)
The Mechanism of HDAC8 in Necrotizing Enterocolitis by Regulating Ferroptosis and Inflammatory Response
Xing LANG, Yuguang GAO, Xinsheng MA, Jingtao LI, Jianxin WEI
2026, 47(3): 34-44.    doi: 10.12259/j.issn.2095-610X.S20260304
Abstract(315) HTML PDF(108)
Molecular Mechanism of Celastrol Intervening in TFEB-Mediated Lysosomal Biogenesis Dysfunction Inhibiting Cataract Formation
Chunmei QI, Xiuhui LI, Zhihui ZHANG
2026, 47(3): 45-53.    doi: 10.12259/j.issn.2095-610X.S20260305
Abstract(285) HTML PDF(113)
Clinical Research
Epidemiological Analysis of Head and Neck Malignant Tumors in a Hospital from 2012 to 2021
Fan WANG, Mao ZHANG, Rong ZENG, Yi REN, Hao DING
2026, 47(3): 54-65.    doi: 10.12259/j.issn.2095-610X.S20260306
Abstract(727) HTML PDF(96)
Diagnostic Performance of Interferon-γ Release Assay Combined with Xpert MTB/RIF for Pulmonary Tuberculosis in AIDS Patients with Low CD4+ T Lymphocyte Counts
Yue ZHAO, Can LIU, Yawei CAO, Yingying ZHANG
2026, 47(3): 66-72.    doi: 10.12259/j.issn.2095-610X.S20260307
Abstract(242) HTML PDF(109)
Effects of Lower Limb Robot Combined with Motor Therapy on Exercise Endurance，Cognitive Function and Limb Function in Stroke Patients with Spastic Hemiplegia
Yu LIU, Liru CUI, AI WEILA RI Guli·, Wenshuang FENG, Qing ZHANG, Hanming WANG, Aoran YANG
2026, 47(3): 73-79.    doi: 10.12259/j.issn.2095-610X.S20260308
Abstract(340) HTML PDF(108)
Risk Factors for Primary Aldosteronism in a Hypertensive Population Predicted by Logistic Regression and Decision Tree Models
Wenxiu XU, Te LI, Qifan GUAN, Jihong DUAN
2026, 47(3): 80-87.    doi: 10.12259/j.issn.2095-610X.S20260309
Abstract(261) HTML PDF(107)
The Moderating Effect of Pain Frequency on Sleep Quality and Anxiety in Young Adults with Chronic Low Back Pain
Rui YANG, Mou WANG, Yifan YANG, Tao DING, Shengliu SHI, Jing XU
2026, 47(3): 88-94.    doi: 10.12259/j.issn.2095-610X.S20260310
Abstract(269) HTML PDF(111)
Efficacy of Semaglutide in Patients with Type 2 Diabetes Mellitus Complicated by Non-alcoholic Fatty Liver Disease and Its Effects on IL-27 and TFEB Levels
Weiwei YUAN, Shengqing HE, Yuan ZANG, Liping DENG
2026, 47(3): 95-104.    doi: 10.12259/j.issn.2095-610X.S20260311
Abstract(487) HTML PDF(107)
Relationship between Serum β2-MG，1，5-AG，GLP-1 and Islet Function in Diabetic Patients and Their Predictive Value for Comorbid Cognitive Impairment
Xing HE, Fang YANG, Siyang LI, Yi LI, Yan WANG
2026, 47(3): 105-113.    doi: 10.12259/j.issn.2095-610X.S20260312
Abstract(274) HTML PDF(102)
The Predictive Value of Serum HSP27，CCL22，sTim-3 for the Prognosis of Periodontitis
Yingjie ZHAO, Han GAO, Yiqi ZHENG, Yang CAO, Xin LIU
2026, 47(3): 114-122.    doi: 10.12259/j.issn.2095-610X.S20260313
Abstract(127) HTML PDF(27)
Expression Levels of t-PA，TN-C and Cav-1 in Patients with Different Clinical Outcomes after Decompressive Craniectomy for Massive Cerebral Infarction
Dongliang GUO, Dehui LI, Na WANG
2026, 47(3): 123-132.    doi: 10.12259/j.issn.2095-610X.S20260314
Abstract(210) HTML PDF(57)
Expression Profiles of KRT17，STOML2 and miR-196a in Cervical Lesions and Their Predictive Value for Cervical Cancer Prognosis
Yihua LÜ, Xueqin DIAO, Shan YU, Xiaorong SUN
2026, 47(3): 133-142.    doi: 10.12259/j.issn.2095-610X.S20260315
Abstract(308) HTML PDF(115)
A Two-year Observation on the Efficacy and Safety of Enzyme Replacement Therapy in a Fabry Disease Pedigree: A Single-center Case Series Report
Min DENG, Yinglu HAO, Min RAN, Qinglin LI, Yanping LI, Ziyang YU
2026, 47(3): 143-150.    doi: 10.12259/j.issn.2095-610X.S20260316
Abstract(292) HTML PDF(129)
Review
Research Progress on Non-coding RNA in the Pathogenesis and Clinical Application of Preeclampsia
Yali LIU, Yao SHEN, Xingqi WU, Jinman ZHANG
2026, 47(3): 151-162.    doi: 10.12259/j.issn.2095-610X.S20260317
Abstract(196) HTML PDF(55)
Research Advances in D-dimer/Fibrinogen Ratio and Fibrinogen/Albumin Ratio in Acute Coronary Syndromes
Jizhou LI, Hongwei LI, Ye ZHANG, Hongling YANG
2026, 47(3): 163-170.    doi: 10.12259/j.issn.2095-610X.S20260318
Abstract(342) HTML PDF(114)
Nursing Forum
Application of a Temporal Self-regulation Theory-guided Nursing Program in the Perioperative Care of Hepatic Arterial Infusion Chemotherapy for Liver Cancer
Xueting HONG, Ruodan CHEN, Xiuyan WANG, Lanxi QIU, Zhenlian SHEN, Ni JIANG
2026, 47(3): 171-180.    doi: 10.12259/j.issn.2095-610X.S20260319
Abstract(325) HTML PDF(119)

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