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Supervisor：Education Department of Yunnan Province Sponsor：Kunming Medical University Chief Editor：Xia Xueshan

ISSN 2095-610X CN 53-1221/R

Address：1168 Chunrong West Road, Yuhua street, Chenggong New City, Kunming

Postal Code：650500 Telephone：0871－65936489 

E-mail：kmykdxxbzk@163.com

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Articles just accepted have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
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Diagnostic Performance of Interferon-γ Release Assay combined with Xpert MTB/RIF for Pulmonary Tuberculosis in AIDS Patients with Low CD4+ T Lymphocyte Counts
Yue ZHAO, Can LIU, Yawei CAO, Yingying ZHANG
Abstract(53) PDF(23)
A Two-Year Observation on the Efficacy and Safety of Enzyme Replacement Therapy in a Fabry Disease Pedigree: A Single-Center Case Series Report
Min DENG, Yinglu HAO, Min RAN, Qinglin LI, Yanping LI, Ziyang YU
Abstract(62) PDF(33)
Expression Profiles of KRT17，STOML2 and miR-196a in Cervical Lesions and Their Predictive Value for Cervical Cancer Prognosis
Yihua LV, Chao CHANG, Xueqin DIAO, Shan YU
Abstract(88) PDF(36)
Efficacy of Semaglutide in Patients with Type 2 Diabetes Mellitus Complicated by Non-alcoholic Fatty Liver Disease and Its Effects on IL-27 and TFEB Levels
Weiwei YUAN, Shengqing HE, Yuan ZANG, Liping DENG
Abstract(53) PDF(21)
Application of a Temporal Self-regulation Theory-guided Nursing Program in the Perioperative Care of Hepatic Arterial Infusion Chemotherapy for Liver Cancer
Xueting HONG, Ruodan CHEN, Xiuyan WANG, Lanxi QIU, Zhenlian SHEN, Ni JIANG
Abstract(49) PDF(23)
Relationship Between Serum β2-MG，1，5-AG，GLP-1 and Islet Function in Diabetic Patients and Their Predictive Value for Comorbid Cognitive Impairment
Xing HE, Fang YANG, Siyang LI, Yi LI, Yan WANG
Abstract(48) PDF(21)
The Moderating Effect of Pain Frequency on Sleep Quality and Anxiety in Young Adults with Chronic Low Back Pain
Rui YANG, Mou WANG, Yifan YANG, Tao DING, Shengliu SHI, Jing XU
Abstract(54) PDF(22)
Expression and Clinical Significance of the Endoplasmic Reticulum PERK/eIF-2α Signaling Pathway in Cervical Cancer
Peipei HE, Ke CHEN, Jun XU, Zhixia WANG, Xuemei YAN
Abstract(60) PDF(25)
The Role of HDAC8 Expression in Necrotizing Enterocolitis Through Ferroptosis and Inflammatory Response
Xing LANG, Yuguang GAO, Xinsheng MA, Jingtao LI, Jianxin WEI
Abstract(66) PDF(25)
The Role and Mechanism of Mitochondrial Ferroptosis in Uremic Toxin-Associated Myocardial Injury
Yaping ZHOU, Fangfang DI, Wei WANG
Abstract(76) PDF(23)
Risk Factors for Primary Aldosteronism in a Hypertensive Population Predicted by Logistic Regression and Decision Tree Models
Wenxiu XU, Te LI, Qifan GUAN, Jihong DUAN
Abstract(66) PDF(24)
Research Advances in D-dimer/Fibrinogen Ratio and Fibrinogen/Albumin Ratio in Acute Coronary Syndromes
Jizhou LI, Hongwei LI, Ye ZHANG, Hongling YANG
Abstract(98) PDF(27)
PCK2 Promotes Malignant Phenotypes of Non-Small Cell Lung Cancer Cells via SLC38A2-Mediated Glutamine Uptake
Libo RUAN, Kewang XU, Minjun ZHAO, Fan ZHANG, Wenjun ZENG, Haiyan ZHANG
Abstract(115) PDF(28)
Expression and Prognostic Value of WDR62 in Hepatocellular Carcinoma
Fuwei ZHANG, Tao WANG, Tao WU
Abstract(82) PDF(28)
Molecular Mechanism of Celastrol Intervening in TFEB-Mediated Lysosomal Biogenesis Dysfunction Inhibiting Cataract Formation
Chunmei QI, Xiuhui LI, Zhihui ZHANG
Abstract(94) PDF(25)
Effects of Lower Limb Robot Combined with Motor Therapy on Exercise Endurance，Cognitive Function and Limb Function in Stroke Patients with Spastic Hemiplegia
Yu LIU, Liru CUI, AI WEILA RI Guli., Wenshuang FENG, Qing ZHANG, Hanming WANG, Aoran YANG
Abstract(87) PDF(25)
Relationship Between Serum CD46，KLF7，FURIN and Clinicopathological Features in Patients with Chronic Cervicitis Combined with HPV Infection and Their Prognostic Predictive Value
Zhiying ZHANG, Peijing SHI
Abstract(121) PDF(26)
Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
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Evaluation Value of AKT/mTOR Signaling Pathway Expression in Peripheral Blood Mononuclear Cells in Patients with Chronic Obstructive Pulmonary Disease
Junjun ZHANG, Zhen LIANG, Yanfang PENG
Abstract(128) PDF(23)
Genomic Analysis of Two Novel Coxsackievirus B2 Strains in 2022
Xiang LI, Zhaoyang CHU, Hengli YANG, Changzeng FENG, Li LI, Jiansheng LIU, Shaohui MA
Abstract(92) PDF(20)
Correlation Between Serum NF-κB，S1P1，and SOCS3 Levels and Disease Severity in Children with Bacterial Infectious Pneumonia，and Their Prognostic Predictive Value
Mengjiao ZHAO, Yanni JU
Abstract(79) PDF(25)
Molecular Docking-Based Screening and Activity Studies of NDM-1 β-Lactamase Inhibitors against Klebsiella pneumoniae
Xiaoyu YANG, Bo LI, Rui ZHENG, Min SU
Abstract(64) PDF(22)
HIF-2Α Promotes Osteoarthritis Progression by Regulating Articular Cartilage Deg-eneration Through Activation of CXCR4
Peng XU, Yazhou XIAO, Zhengliang LEI, Huan LIU, Luchang LIU
Abstract(124) PDF(18)
Correlation Between Energy Spectrum CT Iodine-Based Values and FEV1/FVC in Early-Stage Small Airway Damage of the Lung
Xiang GAO, Cheng YANG
Abstract(82) PDF(22)
Core Active Substances and Molecular Mechanisms of Traditional Chinese Medicine in Treating IgA Nephropathy Based on Data Mining and Network Pharmacology
Chuanqi YANG, Ruolian ZHAO, Yajuan TANG, Zijie LIU, Huan LI, Hui ZHANG, Lin CHAI
Abstract(255) PDF(24)
Therapeutic Effects of Ultrasound-guided Closed Thoracic Drainage in Patients with Complex and Refractory Pneumothorax and Its Impact on Inflammatory Factors and Pulmonary Function
Dan LIU, Shanglin BAI, Xu WU, Wangsheng REN, Xianyu WU, Hang ZENG, Guo XU
Abstract(147) PDF(18)
Trajectories and Influencing Factors of Cancer-related Anorexia in Nasopharyngeal Carcinoma Patients under Local Hypothermia Care Combined with Nutritional Intervention for Radiation-induced Oral Mucositis
Yaping HU, Peijuan CHEN, Dan LI, Lian. HE
Abstract(88) PDF(18)
Disease Burden of Hypertensive Nephropathy Attributable to High Sodium Diet in China，Japan，and the United States During 1990-2021 and Its Predictive Analysis
Lanxi FANG, Guanlin LIU, Yuhang YANG, Delong ZHAO, Wanchen DAI, Qiong MENG
Abstract(93) PDF(17)
The Burden and Trends of Ischemic Heart Disease Attributable to Low Physical Activity Globally and in China，1990—2021
Changyong WU, Zhongkai WANG, Menghan LI, Bingqing ZHANG, Yihua LUO, Yunzhu PENG
Abstract(166) PDF(35)
Effects of Dexmedetomidine Combined with Sufentanil on Pain Sensitization and Spinal Inflammatory Response in Rats with Incisional Pain
Huizhen GAO, Qingling YANG, Yanan ZHANG, Shujun GAO
Abstract(178) PDF(29)
Awareness of the Core Knowledge of Cancer Prevention and Control in Ethnic Minority Areas of Yunnan，China:A Cross-Sectional Study
Hai ZHOU, Jun HE, Fengjian SA, Sile LI, Yongcun CEN, Jie MA, Yunchao HUANG
Abstract(182) PDF(30)
Propofol Modulates the miR-142-3p/RAC1/NF-κB Axis to Influence Knee Osteoarthritis in Rats
Chengneng FAN, Jintao SHI, Shuangwei LU, Meng YU
Abstract(98) PDF(30)
Correlation and Predictive Value of Serum MiR-155，HBP and AECOPD Treatment Efficacy
Yang LI, Xueting YANG, Liling DING, Jie LONG
Abstract(114) PDF(26)
Application of miR-132，BDNF and NRG-1 in the Diagnosis and Prognosis of AI-related Vascular Dementia
Saibing LIU, Liping YAN, Ani SUN
Abstract(117) PDF(20)
Correlation and Significance of FCN3，IGF-1 and Immune Function in Children with Recurrent Respiratory Tract Infection
Jing LAN, Huaying YANG, Jianhong CHENG
Abstract(118) PDF(26)
Establishment of a Nomogram Model for Predicting Abnormal Bone Mass in Diabetic Patients
Hui LIU, Xinyi PENG, Tonger LIANG, Yong ZHAO
Abstract(143) PDF(24)
Research Progress on Bacteriophage Prevention and Treatment of Dental Caries
Zehua HAN, Xiaoyan YANG, Yuliang CHEN, Xuelin LI, Rongyu YANG, Yingying XIANG
Abstract(164) PDF(25)
Serological Features of Neurological Involvement in ANCA-associated Vasculitis and Their Predictive Value for Prognosis
Chunrong YAO, Danqing HUANG, Yini KE
Abstract(202) PDF(27)
The Prognostic Value of Uterine Artery Blood Flow Combined with Serum Factors for Preeclampsia in Mid-pregnancy
Ruiyan LEI, Huimin HAO, Peiying WANG, Hui SUN, Li ZHANG
Abstract(205) PDF(45)
TMAO Inhibitors' Effects on Diabetic Sarcopenia in Rats
Shuimei LIAN, Qian YANG, Ting WANG
Abstract(163) PDF(45)
Mechanism of miR-21-5p in Promoting Osteoarthritis Progression through Inhibition of the SIRT2/AKT Signaling Pathway
Xiaotian CHEN, Zhenfei DING, Yining SONG, Banghong JIANG, Fan ZHANG, Yi GAO, Jianzhong GUAN
Abstract(152) PDF(41)
Mechanistic Study of the Inhibitory Effects of Hedyotis diffusa Ethanol Extract on Breast Cancer Cells via Activation of the Cyt-c/Caspase-9–Related Mitochondrial Pathway
Xiaoxiao LIAN, Tao HAN, Kunmeng CUI, Yan WANG, Yongfang LIU, Tian GUO, Ruixue YANG, Ya WANG
Abstract(125) PDF(37)
Effects of Sanqi Oral Liquid on Glycolysis，Renal Cell Apoptosis，and Keap1-Nrf2 Signaling Pathway in Diabetic Nephropathy Rats
Wenchao LI, Xue LI, Shanshan LIN, Yun MA, Guorui KANG, Ye CHEN
Abstract(271) PDF(25)
Study on the Mechanism by Which GPX4 Expression Promotes Ferroptosis and Participates in Malignant Behavior of Endometrial Carcinoma
Xiaoxia DONG, Shuxian CHEN
Abstract(393) PDF(106)
Epidemiological Analysis of Head and Neck Malignant Tumors in a Hospital from 2012 to 2021
Fan WANG, Rong ZENG, Mao ZHANG, Yi REN, Hao DING
Abstract(472) PDF(24)
Molecular Mechanism of the YAP1/ANXA2 Signaling Axis in Regulating Apoptosis and Migration of Renal Tubular Epithelial Cells
Shaoting SUN, Lanmei LI, Weiwei BAI, Na CHEN, Meng WANG, Ming ZHANG, Yafen LI
Abstract(299) PDF(22)
Research Advances in D-dimer/Fibrinogen Ratio and Fibrinogen/Albumin Ratio in Acute Coronary Syndromes
Jizhou LI, Hongwei LI, Ye ZHANG, Hongling YANG
Abstract(430) PDF(30)
Studies on the Correlation between Esophageal Manometry and Short-Term Efficacy of Endoscopic Myomectomy in Patients with Achalasia
Yingye SONG, Juanping LI, Rui LI
Abstract(260) PDF(36)
Analysis of the Value of Serum Testosterone，Sex Hormone-Binding Globulin and Vitamin D Levels in Predicting Gestational Diabetes Mellitus Complicated by Polycystic Ovary Syndrome
Yuzhen ZHAO, Yingyan MA, Lili HE
Abstract(479) PDF(40)
Efficacy of Butylphthalide Combined with Atorvastatin in the Treatment of Cerebral Infarction and Its Effects on the Expression of vWF，PAI-1 and Ve Cadherin in Vascular Endothelium
Kejiao LI, Zichen LIU, Sha CHANG, Xue SONG, Fang LI
Abstract(270) PDF(11)
Expert Consensus on the Diagnosis and Treatment of Chronic Coronary Syndrome with Traditional Chinese and Western Medicine in Yunnan Province
Li ZHANG, Ying ZHANG, Xueya ZHANG, Zhuo YU
Abstract(589) PDF(26)
Column
Expert Forum
Neuroinflammatory Biomarkers and Related Pharmacological Treatment in Alzheimer's Disease
Zirong MA, Shaochuan ZHANG, Xue CAO, Yutao WANG, Qingrong LI
2026, 47(2): 1-13.    doi: 10.12259/j.issn.2095-610X.S20260201
Abstract(120) HTML PDF(25)
Original Articles Basic of Medicine
Mechanisms of Collagen-associated Integrin α1，α2 and β1 in the Caveolin-1/AQP1 Pathway During Scleral Remodeling in the Recovery Phase of Form-deprivation Myopia
Lulu CHEN, Yabin DONG
2026, 47(2): 14-20.    doi: 10.12259/j.issn.2095-610X.S20260202
Abstract(61) HTML PDF(20)
Predicting Active Components of Chinese Herbal Medicines for Treating Bone Aging Based on Reverse Network Pharmacology and Molecular Docking
Lirong GUO, Xiang LIU, Jiahao LI, Ying ZHANG
2026, 47(2): 21-34.    doi: 10.12259/j.issn.2095-610X.S20260203
Abstract(213) HTML PDF(24)
Mechanism of TPI-1 in Promoting the Proliferation and Invasion of Gastric Cancer Cells through Glycolytic Reprogramming
Haiwei WANG, Xiaohui ZHANG, Yunxiao TIAN, Shiqian WU
2026, 47(2): 35-42.    doi: 10.12259/j.issn.2095-610X.S20260204
Abstract(140) HTML PDF(19)
Gastrodin Ameliorates Maternal-fetal Interface Injury in Gestational Diabetes Mellitus Rats by Activating the GPR120/AMPK Pathway
Nan LI, Ziyi NIU, Lan SHAO
2026, 47(2): 43-50.    doi: 10.12259/j.issn.2095-610X.S20260205
Abstract(304) HTML PDF(19)
Clinical Research
Inhibitory Effect of Low-molecular-weight Heparin and Insulin Supplemented with Fenofibrate Capsules on Local Inflammation in Patients with Hypertriglyceridemic Acute Pancreatitis
Yao TANG, Ting XU, Jun WU
2026, 47(2): 51-59.    doi: 10.12259/j.issn.2095-610X.S20260206
Abstract(432) HTML PDF(21)
Predictive Value of Lipoprotein（a） and Pericoronary Adipose Tissue Attenuation Index in Risk Assessment of Coronary Heart Disease
Baofa LUO, Cunwen MA, Chengshi DENG, Lingchuan MA, Bowen ZHANG, Fei JIANG
2026, 47(2): 60-67.    doi: 10.12259/j.issn.2095-610X.S20260207
Abstract(109) HTML PDF(21)
Comparative Analysis of caIMR and CMR in Assessing Coronary Microvascular Dysfunction and Correlation of Cardiac and Cerebral Microvascular Lesions
Min YU, Lin SUN
2026, 47(2): 68-82.    doi: 10.12259/j.issn.2095-610X.S20260208
Abstract(263) HTML PDF(27)
Intervention Mechanism of miR-155 in Macrophage-derived Exosomes from Sepsis Patients on Endothelial Cell Ferroptosis
Zhijie CHENG, Ruijing ZUO, Huanhuan LI, Linxia WU, Minchen KAN, Qianqian WANG
2026, 47(2): 83-92.    doi: 10.12259/j.issn.2095-610X.S20260209
Abstract(153) HTML PDF(19)
Analysis of Cervical Cancer Awareness and Self-sampling HPV Testing Accuracy Among Rural Women in Xiangyun County
Xinyue XU, Rufei DUAN, Kehui LUO, Hongying YANG, Hongyan YANG, Sheye YANG
2026, 47(2): 93-100.    doi: 10.12259/j.issn.2095-610X.S20260210
Abstract(70) HTML PDF(21)
Correlation Between Metabolic Syndrome and Diabetic Retinopathy
Chunhui ZHANG, Long YANG, Xu ZHA, Liqiong ZHOU, Quan CHENG, Yuanping ZHANG
2026, 47(2): 101-114.    doi: 10.12259/j.issn.2095-610X.S20260211
Abstract(82) HTML PDF(24)
Correlation between Infant Sleep and Cognitive Development
Yanqiong RAO, Shujin LI, Jihua CUI, Yanhui SUN, Yu SONG, Yanfei YANG, Yu LING
2026, 47(2): 115-123.    doi: 10.12259/j.issn.2095-610X.S20260212
Abstract(120) HTML PDF(18)
Weight Gain Pattern during Pregnancy and Its Association with Delivery Fear and Cesarean Section Rate in Primiparous Women
Xiaoli CHAI, Li LI, Zhigang LIU, Wenyu YAN
2026, 47(2): 124-132.    doi: 10.12259/j.issn.2095-610X.S20260213
Abstract(350) HTML PDF(23)
Relationship between Serum PON-1，NDRG4 and SFRP4 Expression，Peripheral Blood Immune Cell Distribution，and Prognosis in Gastric Cancer Patients
Tian TIAN, Xiaodong YANG, Shujie GE
2026, 47(2): 133-142.    doi: 10.12259/j.issn.2095-610X.S20260214
Abstract(261) HTML PDF(27)
Review
CGRP-mediated Cancer Pain Mechanisms and Targeted Therapeutic Approaches
Beining TANG, Shihao SHAO, Tao LI, Yun SHA, Jinyuan YANG, Zejing HUANGFU, Xinyu GU, Zhonghui WANG
2026, 47(2): 143-155.    doi: 10.12259/j.issn.2095-610X.S20260215
Abstract(202) HTML PDF(23)
Teaching Research
Cultivating Critical Thinking Ability in Clinical Medical Students of Tumor Interventional Radiology through Case-based Heuristic Teaching Method
Fangfang XIONG, Lanxi QIU, Haoyuan LI, Jinfeng BAI, Ming HUANG, Rong DING
2026, 47(2): 156-163.    doi: 10.12259/j.issn.2095-610X.S20260216
Abstract(170) HTML PDF(22)
Optimization and Practice of LD50 Experimental Teaching Based on An Alcohol Model
Lan GAO, Yuanhang YANG, Kaixuan QIN, Lei ZHANG
2026, 47(2): 164-170.    doi: 10.12259/j.issn.2095-610X.S20260217
Abstract(116) HTML PDF(21)
Nursing Forum
Influencing Factors and Correlation between Death Anxiety and Death Attitudes in Patients with Advanced Lung Cancer
Dingyi ZHANG, Yuelin LI, Yunhua WANG, Yiheng CHEN, Qian ZHANG, Yulin LU
2026, 47(2): 171-180.    doi: 10.12259/j.issn.2095-610X.S20260218
Abstract(136) HTML PDF(22)

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