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胆绿素治疗作用的研究进展

白文娅,  杨渊,  霍思颖,  杨鑫,  邵建林

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文章导航 > 昆明医科大学学报  > 2022 >  43(6): 147-153
白文娅, 杨渊, 霍思颖, 杨鑫, 邵建林. 胆绿素治疗作用的研究进展[J]. 昆明医科大学学报, 2022, 43(6): 147-153. doi: 10.12259/j.issn.2095-610X.S20220601
引用本文: 白文娅, 杨渊, 霍思颖, 杨鑫, 邵建林. 胆绿素治疗作用的研究进展[J]. 昆明医科大学学报, 2022, 43(6): 147-153. doi: 10.12259/j.issn.2095-610X.S20220601
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Wenya BAI, Yuan YANG, Siying HUO, Xin YANG, Jianlin SHAO. Advances in Research Progress on the Therapeutic Function of Biliverdin[J]. Journal of Kunming Medical University, 2022, 43(6): 147-153. doi: 10.12259/j.issn.2095-610X.S20220601
Citation: Wenya BAI, Yuan YANG, Siying HUO, Xin YANG, Jianlin SHAO. Advances in Research Progress on the Therapeutic Function of Biliverdin[J]. Journal of Kunming Medical University, 2022, 43(6): 147-153. doi: 10.12259/j.issn.2095-610X.S20220601
shu

胆绿素治疗作用的研究进展

doi: 10.12259/j.issn.2095-610X.S20220601

  • 昆明医科大学第一附属医院麻醉科，云南 昆明　650032

基金项目: 国家自然科学基金资助项目（81960250）；云南省教育厅科研基金资助项目（2022J0192）；云岭产业技术领军人才项目（YLXL20170054）
详细信息
    作者简介:

    白文娅（1993～），女，山东菏泽人，在读博士研究生，住院医师，主要从事围术期器官保护工作

    通讯作者:

    杨鑫，E-mail： 1817415847@qq.com

    邵建林，E-mail： cmushaoji@aliyun.com

  • 中图分类号: R614.2

Advances in Research Progress on the Therapeutic Function of Biliverdin

  • Dept. of Anesthesiology，The 1st Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650032，China

    摘要
  • 摘要: 胆绿素、胆红素是血红素代谢的产物。有研究发现，胆绿素依靠胆绿素-胆红素氧化还原系统，不断地消耗氧自由基，激活胆绿素还原酶，从而发挥抗氧化、抗炎、抑制免疫反应、稳定血管内皮细胞、调控细胞凋亡等作用。将从胆绿素、胆红素的结构与代谢、胆绿素的作用及机制等方面作一综述。
    Abstract: Biliverdin and bilirubin are the products of heme metabolism. Many studies have found that biliverdin can continuously consume oxygen free radicals as well as activate biliverdin reductase, relying on the biliverdin-bilirubin redox recycling system. Biliverdin may play a crucial of antioxidant, anti-inflammatory, suppressing immune response, stabilizing vascular endothelial cells, regulating cell apoptosis and so on. In this review, we discussed the structure and metabolism of biliverdin/bilirubin, and mechanism of biliverdin therapeutic function in different diseases.
    • HTML全文

  • 图  1  胆绿素、胆红素氧化还原系统

    注：血红素在HO-1、CPR的作用下，生成胆绿素、一氧化碳（CO）、铁离子（Fe2+），接着胆绿素又在BVR的作用下还原成胆红素，胆红素又可通过和ROS反应，氧化成胆绿素。HO-1：血红素氧合酶1；CPR：细胞色素P450还原酶；BVR：胆绿素还原酶；ROS：活性氧自由基；NADPH：烟酰胺腺嘌呤二核苷酸磷酸；CO：一氧化碳。

    Figure  1.  The biliverdin-bilirubin redox recycling system

    下载: 全尺寸图片 幻灯片

    图  2  胆绿素作用及机制图

    注：PI3K/Akt信号通路：磷脂酰肌醇-3-激酶/蛋白激酶B；MAPK信号通路： p38促分裂原活化的蛋白激酶；NF-κB信号通路：核因子κB信号通路；NLRP3：核苷酸寡聚结合域样受体热蛋白结构域相关蛋白 3；NFAT：活化T细胞核因子；AAG：α1-酸糖蛋白。

    Figure  2.  Role of biliverdin in different pathophysiological processes

    下载: 全尺寸图片 幻灯片
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  • 收稿日期:  2022-03-13
  • 刊出日期:  2022-06-25

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