Research Progress on the Correlation between Serum Uric Acid and Head and Neck Tumors
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摘要: 尿酸是嘌呤代谢的最终产物，也是重要的内源性抗氧化剂，尿酸通过其抗氧化和促氧化作用在不同恶性肿瘤中发挥不同作用并与多种恶性肿瘤的发生、发展和预后密切相关。血清尿酸与头颈肿瘤如口腔癌、喉癌、鼻咽癌、甲状腺肿瘤等的相关性研究报道较少，本文对血清尿酸与头颈肿瘤发生、发展及预后的相关性进行综述以期揭示尿酸在头颈肿瘤预防、诊断和治疗中的价值。Abstract: Uric acid is the final product of purine metabolism and an important endogenous antioxidant. Uric acid plays different roles in different malignant tumors through its antioxidant and pro-oxidative effects, and is closely related to the occurrence, development and prognosis of various malignant tumors. There are few reports on the correlation between serum uric acid and head and neck tumors, such as oral cancer, larynx cancer, nasopharyngeal cancer, thyroid cancer, etc. In this paper, the correlation between serum uric acid and the occurrence, development and prognosis of head and neck tumors is reviewed to reveal the value of uric acid in the prevention, diagnosis and treatment of head and neck tumors.
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Key words:
- Uric acid /
- Head and neck tumors /
- Thyroid tumor /
- Etiology
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图 2 口腔癌、喉癌、鼻咽癌“尿酸-微生物-免疫”交互作用可能机制
Akt：丝氨酸/苏氨酸激酶；IM：炎症微环境；IL-1β：白介素-1β；IL-6：白介素-6；LMP1：EB病毒潜伏膜蛋白1；MAPK：丝裂原激活蛋白激酶；M2：巨噬细胞（M2型）；NF-κB：转录因子-κB；NLRP3：核苷酸结合寡聚化结构域样受体蛋白3炎症小体；ROS：活性氧族；TNF-α：肿瘤坏死因子-α；UA：尿酸。
Figure 2. The “uric acid-microbiota-immunity” interaction mechanism in oral cancer，laryngeal cancer and nasopharyngeal carcinoma
图 3 尿酸影响甲状腺肿瘤发生发展的可能机制
CREB：环磷腺苷效应元件结合蛋白；IL-1β：白介素-1β；IL-6：白介素-6；IRS1：胰岛素受体底物1；NF-κB：转录因子-κB；NLRP3：核苷酸结合寡聚化结构域样受体蛋白3炎症小体；PKA：蛋白激酶A；PKB：蛋白激酶B；ROS：活性氧族；TNF-α：肿瘤坏死因子-α；TSH ：促甲状腺激素；UA 尿酸。
Figure 3. Possible mechanisms by which uric acid affects the occurrence and development of thyroid tumors
表 1 高尿酸血症与头颈部主要肿瘤类型发病风险和/或预后的关系
Table 1. The relationship between hyperuricemia and the risk of and/or prognosis of the main tumor types in the head and neck region
肿瘤类型 发病风险/预后 相关研究纳入的
最大病例数甲状腺结节
（良性）发病风险增加 698.6万例 甲状腺癌 发病风险增加、预后较差 139例 鼻咽癌 预后较差 341例 喉癌 预后较好 814例 口腔癌 发病风险降低 145例 食管癌 预后较差 209例 
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