Volume 42 Issue 7
Jul.  2021
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Article Navigation >  Journal of Kunming Medical University  > 2021  >  42(7): 20-24
Xibing Zhang, Ling Niu, Fang Liu, Jianghua Ran. The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases[J]. Journal of Kunming Medical University, 2024, 45(12): 1-9. doi: 10.12259/j.issn.2095-610X.S20241201
Citation: Hu ZHANG, An-rui PENG, Jia-ji ZHONG, Bo HUANG. Signal Pathway Related Mechanism of Vein Graft Failure in Coronary Artery Bypass Grafting[J]. Journal of Kunming Medical University, 2021, 42(7): 20-24. doi: 10.12259/j.issn.2095-610X.S20210704
shu

Signal Pathway Related Mechanism of Vein Graft Failure in Coronary Artery Bypass Grafting

doi: 10.12259/j.issn.2095-610X.S20210704
  • 1.

    Dept. of Cardiavascular Surgery

  • 2.

    Dept. Of Operating Room，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

  • Received Date: 2021-05-22
    Available Online: 2021-07-19
  • Publish Date: 2021-07-21
    Abstract
  •   Objective  To explore the signal pathway of vein graft failure in coronary artery bypass grafting.  Methods  40 rabbits were randomly divided into two groups. Group A was sham operation group; Group B was model group in which rabbit model of CABG was established. The jugular vein in group A and the graft vein group B was removed 2 days and 2 weeks after the vein grafting, and pathological section was used to quantify lumen stenosis, immunohistochemistry was used to detect the phosphorylated p38, and the indexes were comared.  Results  Compared with group A, the degree of luminal stenosis of group B were significantly higher in 2 weeks after vein graft （P < 0.05）. The expression of p-p38 in vein graft tissue of group B were significantly higher than group A in 2 days and 2 weeks after vein grafting, p-p38 were significantly higher 2 days than 2 weeks after vein grafting in group B （P < 0.05）.  Conclusion  The mechanism of vein graft failure in CABG might be related to the p38 MAPK signal pathway.
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    • References(14)
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