Association between Calcitonin Receptor Gene Polymorphism and Type 2 Diabetes with Osteoporosis in Kunming

Bo-yi LI; Ling NIU; Rong MA; Xian ZHANG; Fang LIU; Yan TANG; Cui-juan MIAO; Zhu-jun HAN; Cheng ZHANG

doi:10.12259/j.issn.2095-610X.S20210709

Volume 42 Issue 7

Jul. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(7): 57-63

Bo-yi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cui-juan MIAO, Zhu-jun HAN, Cheng ZHANG. Association between Calcitonin Receptor Gene Polymorphism and Type 2 Diabetes with Osteoporosis in Kunming[J]. Journal of Kunming Medical University, 2021, 42(7): 57-63. doi: 10.12259/j.issn.2095-610X.S20210709

Citation:

Bo-yi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cui-juan MIAO, Zhu-jun HAN, Cheng ZHANG. Association between Calcitonin Receptor Gene Polymorphism and Type 2 Diabetes with Osteoporosis in Kunming[J]. Journal of Kunming Medical University, 2021, 42(7): 57-63. doi: 10.12259/j.issn.2095-610X.S20210709

Citation:

Bo-yi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cui-juan MIAO, Zhu-jun HAN, Cheng ZHANG. Association between Calcitonin Receptor Gene Polymorphism and Type 2 Diabetes with Osteoporosis in Kunming[J]. Journal of Kunming Medical University, 2021, 42(7): 57-63. doi: 10.12259/j.issn.2095-610X.S20210709

PDF( 728 KB)

Association between Calcitonin Receptor Gene Polymorphism and Type 2 Diabetes with Osteoporosis in Kunming

doi: 10.12259/j.issn.2095-610X.S20210709

Dept. of Endocrinology，The First People’s Hospital of Kunming，Kunming Yunnan 650011，China

Received Date: 2021-04-19
Available Online: 2021-07-19
Publish Date: 2021-07-21

Abstract

Abstract

Objective To study the relationship between calcitonin receptor （CTR） gene polymorphism and type 2 diabetes （T2DM） with osteoporosis in Kunming area, and to explore the genetic predisposing factors of T2DM with osteoporosis. Methods A total of 237 T2DM patients who were hospitalized in the Department of Endocrinology, Ganmei Hospital, the First People’ s Hospital of Kunming from June 2017 to January 2019 were collected. According to the results of bone mineral density, they were divided into T2DM without osteoporosis （group A）, 61 cases, and T2DM combined with osteopenia （Group B）, 111 cases, T2DM with osteoporosis group （Group C） 65 cases. By using polymerase chain reaction （PCR-RFLP） and restriction fragment length polymorphism technology, we analyzed the CTR gene polymorphism of the three groups of people, and compared the three groups of patients with gender, age, diabetes course, blood pressure, height, weight, body mass index （BMI）, fasting blood glucose （FPG）, glycosylated hemoglobin （HbA1c）, blood calcium, blood lipids, blood uric acid （UA）, vitamins D concentration, estrogen, testosterone levels, high-sensitivity C-reactive protein （Hs-CRP）, fibrinogen （FIB）, oral glucose tolerance （OGTT） -0 h, 2 h blood glucose, 0 h, 2 h insulin （INS） levels, insulin Resistance index（HOMA-IR）clinical indicators. We also compared the bone mineral density of different parts of the CTR genotype in 237 cases of T2DM and 65 cases of T2DM with osteoporosis, and compared the CTR genotype and the clinical indicators with statistical differences between the three groups Multivariate logistic regression analysis. Results （1） In patients with T2DM and T2DM with osteoporosis in Kunming area. The CTR genotype was mainly type CC. （2） There was no significant difference in the distribution frequency of CTR genotype between the three groups A, B and C （P > 0.05））. The distribution frequencies of CTR alleles C and T in the three groups were not statistically different （P > 0.05）. （3） There was a statistically significant difference in the age, height, weight, and BMI of the three groups of patients （P < 0.05）. And pairwise comparison, the difference was statistically significant （P < 0.017）. （4） In patients with T2DM and T2DM with osteoporosis, the difference in bone mineral density of different CTR genotypes at each site was not statistically significant （P > 0.05）. （5） Multivariate logistic regression analysis showed that age was an independent risk factor for T2DM with osteoporosis in Kunming. Conclusions （1） In patients with T2DM and T2DM with osteoporosis in Kunming, the CTR gene distribution is mainly of type CC. （2） In patients with T2DM with normal bone mass, T2DM with osteopenia, and T2DM with osteoporosis, CTR has no significant difference in the frequency of genotype distribution and allele distribution frequency; In patients with T2DM and T2DM with osteoporosis, the bone density of different CTR genotypes did not differ at each site. The CTR genotype may have nothing with genetic susceptibility in T2DM and T2DM with bone in Kunming. （3） BMI is a protective factor for T2DM without osteoporosis in Kunming, and proper weight gain has a positive significance in preventing and treating T2DM with osteoporosis. （4） Age is an independent risk factors for T2DM with osteoporosis in Kunming.
- Calcitonin receptor gene polymorphism,
- Type 2 diabetes,
- Osteoporosis

FullText(HTML)

References(13)

References

[1]	王南飞,陈路. 川北地区老年骨质疏松性骨折临床分析[J]. 川北医学院学报,2015,30(6):864-867. doi: 10.3969/j.issn.1005-3697.2015.06.33
[2]	GordonGong,Gleb Haynatzki,Vera Haynatzka,et al. Bone miberal density-affecting denes in Africans[J]. J The National Medical Association,2006,98(7):1102-1108.
[3]	中华医学会糖尿病学分会. 中国2型糖尿病防治指南[J]. 中国糖尿病杂志,2014,22(8):2-42.
[4]	中华医学会骨质疏松和骨矿盐分会. 原发性骨质疏松症诊治指南[J]. 中华骨质疏松和骨矿盐疾病杂志,2011,4(1):2-17. doi: 10.3969/j.issn.1674-2591.2011.01.002
[5]	Nicodemus K K,Folsom A R. Type 1and type 2 diabetesand incident hip fractures in postmenopausal women[J]. Diabetes Care,2001,24(7):1192-1197. doi: 10.2337/diacare.24.7.1192
[6]	周后德,满晓朏,周智广. 糖尿病对骨代谢的影响[J]. 中华医师杂志,2014,16(2):156-160.
[7]	杨军. CTR基因多态性与绝经后妇女2型糖尿病伴骨质疏松症的相关性研究[D]. 上海: 同济大学附属同济医院硕士学位论文, 2009.
[8]	孟德锋,杨立,张斌,等. 维生素受体和降钙素受体基因多态性与新疆地区汉族女性人群骨密度的相关性[J]. 广东医学,2017,38(9):1343-1347. doi: 10.3969/j.issn.1001-9448.2017.09.011
[9]	章振林,孟迅吾,周学瀛,等. 北京地区汉族妇女维生素D受体基因和降钙素受体基因多态性与骨密度的关系[J]. 中华内分泌代谢杂志,2002,18(2):90-94. doi: 10.3760/j.issn:1000-6699.2002.02.002
[10]	李东风,吴文,蔡雪珍,等. 降钙素受体基因多态性与广州地区绝经后妇女骨密度关系研究[J]. 华南预防医学,2005,3l(6):12-14.
[11]	Tsai F J,Chen W C,Chen H Y,et a1. The ALU—I calcitonin receptor gene pelymorphism(1W is associatedwith low bone mineral density and susceptibility to osteoporosis in postmenopausal women[J]. Gynecol Obetet Invest,2003,55(2):82-87. doi: 10.1159/000070179
[12]	Nakamura M,Zhang Z Q,Shan L,el a1. Allelic variants of human calcitonin receptor in the Japanese population[J]. Hum Genet,1997,99(1):3841.
[13]	Masi L,Becherini L,Germari L,et a1. Allelic vraiants of human calcitonin receptor distribution and association with bone mass in postmenopausal women[J]. Bioch Biophys Res Commun,1998,245(2):622-626. doi: 10.1006/bbrc.1998.8445

Relative Articles(20)

Relative Articles

[1]	Xinlin ZHU, Yanan WU, Qi MENG, Qianzi YANG, Yuanbiao LI, Junheng TAO, Mengyang HE. Influence of Medication Compliance of Type 2 Diabetes Chronic Disease Management Patients in Two Communities of Kunming on Disease Control. Journal of Kunming Medical University, 2024, 45(3): 79-83. doi: 10.12259/j.issn.2095-610X.S20240312
[2]	Ling NIU, Rong MA, Cheng ZHANG, Cuijuan MIAO, Yan TANG, Fang LIU, Boyi LI. Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis. Journal of Kunming Medical University, 2024, 45(6): 106-112. doi: 10.12259/j.issn.2095-610X.S20240614
[3]	Hong TAN, Hejia YIN, Yan LI, Qin HU, Lan LI, Zundan REN, Rou SHI. Correlation between DDAH1 Gene 836A/T Polymorphism and Type 2 Diabetic Kidney Disease in Yunnan Han Population. Journal of Kunming Medical University, 2023, 44(6): 26-32. doi: 10.12259/j.issn.2095-610X.S20230621
[4]	Boyi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cuijuan MIAO, Cheng ZHANG, Zhujun HAN. The Relationship Between T950C Polymorphism in the Promoter Region of Osteoprotegerin Gene and Type 2 Diabetes with Osteoporosis. Journal of Kunming Medical University, 2022, 43(3): 67-73. doi: 10.12259/j.issn.2095-610X.S20220306
[5]	Li-xuan YAO, Ben NIU, Wei YUE, Wen-lin ZHOU, Ya-ting ZHANG. Correlation Between Hepatitis C Virus Infection and Type 2 Diabetes Mellitus. Journal of Kunming Medical University, 2021, 42(8): 83-89. doi: 10.12259/j.issn.2095-610X.S20210815
[6]	Cong MEI, Xiao-chun WENG, Bao-kun PENG, Sui-jun YAN, Chun LI, Qiong ZHOU, Zhe TANG. Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality. Journal of Kunming Medical University, 2021, 42(3): 135-139. doi: 10.12259/j.issn.2095-610X.S20210332
[7]	Ling NIU, Bo-yi LI, Cheng ZHANG, Rong MA, Yan TANG, Fang LIU, Li-min YIN, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. Relationship between Calcitonin Receptor，Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 42(11): 74-80. doi: 10.12259/j.issn.2095-610X.S20211114
[8]	Ling NIU, Bo-yi LI, Jing-qiu MAO, Yan TANG, Rong MA, Fang LIU, Chen ZHANG, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. The Relationship between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 42(7): 70-76. doi: 10.12259/j.issn.2095-610X.S20210711
[9]	Bo-yi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cui-juan MIAO, Zhu-jun HAN, Cheng ZHANG. The Relationship between T950C Polymorphism in the Promoter Region of Osteoprotegerin Gene and Type 2 Diabetes with Osteoporosis in Kunming Area. Journal of Kunming Medical University, 2021, 43(): 1-8. doi: 10.12259/j.issn.2095-610X.S20211112
[10]	Liu Jun Ping , Liang Jie , Su Bing Chi , Ma Jia , Wang Rui Ping . Multivariate Analysis of the Influence Factors of Osteoporosis in Elderly Patients with Type 2 Diabetes Mellitus. Journal of Kunming Medical University, 2017, 38(07): 111-114.
[11]	Zhang Qi Wei , Li Hai Feng , Li Qun Hui . Epidemiological Investigation of Osteoporosis in Kunming. Journal of Kunming Medical University, 2017, 38(04): 35-39.
[12]	Zheng Dang . The Efficacy and Safety of Alpha Lipoic Acid Combined with Methycobal for Patients with Type-2 Diabetes Combined with Diabetic Peripheral Neuropathy. Journal of Kunming Medical University,
[13]	Han Wen Ju , Niu Ben , Liang Yun, Duan Xiao Yan , Su Heng , Xue Yuan Ming . The Relationship between Thyroid Hormone and Purine Metabolism and Body Weight in Patients with Type II Diabetes and Normal Thyroid Function. Journal of Kunming Medical University, 2016, 37(11): 82-85.
[14]	Nian Xin . Difference of Metallothionein Gene G-201A Polymorphism in Type 2 Diabetes and Essential Hypertension. Journal of Kunming Medical University,
[15]	Yang Zai Ying . The Effect of Osteoporosis on the Pathogenesis of Osteoarthritis. Journal of Kunming Medical University,
[16]	Long Qiong Hua . . Journal of Kunming Medical University,
[17]	Deng De Yao . . Journal of Kunming Medical University,
[18]	Wang Yan . . Journal of Kunming Medical University,
[19]	Nian Xin . The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol. Journal of Kunming Medical University, 2012, 33(02): 1-1.
[20]	Li Jing . . Journal of Kunming Medical University,