Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD

Sheng-hao LI; Jie DING; Qing-qing WANG; Si-qi LIU; Li-juan HUA; Jin-yu DUAN; Bao-li BO; An-rui DU; Guo-ji CHANG; Jun-yi LI

doi:10.12259/j.issn.2095-610X.S20210712

Volume 42 Issue 7

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(7): 77-82

Sheng-hao LI, Jie DING, Qing-qing WANG, Si-qi LIU, Li-juan HUA, Jin-yu DUAN, Bao-li BO, An-rui DU, Guo-ji CHANG, Jun-yi LI. Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD[J]. Journal of Kunming Medical University, 2021, 42(7): 77-82. doi: 10.12259/j.issn.2095-610X.S20210712

Citation:

Sheng-hao LI, Jie DING, Qing-qing WANG, Si-qi LIU, Li-juan HUA, Jin-yu DUAN, Bao-li BO, An-rui DU, Guo-ji CHANG, Jun-yi LI. Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD[J]. Journal of Kunming Medical University, 2021, 42(7): 77-82. doi: 10.12259/j.issn.2095-610X.S20210712

Citation:

Sheng-hao LI, Jie DING, Qing-qing WANG, Si-qi LIU, Li-juan HUA, Jin-yu DUAN, Bao-li BO, An-rui DU, Guo-ji CHANG, Jun-yi LI. Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD[J]. Journal of Kunming Medical University, 2021, 42(7): 77-82. doi: 10.12259/j.issn.2095-610X.S20210712

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Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD

doi: 10.12259/j.issn.2095-610X.S20210712

1.
Dept. of Infectious Disease
2.
Dept. of Information，The Third People’s Hospital of Kunming，Kunming Yunnan 650041，Kunming Yunnan 650041，China

Received Date: 2021-04-25
Available Online: 2021-07-19
Publish Date: 2021-07-21

Abstract

Abstract

Objective To investigate the influencing factors of liver injury in patients with chronic hepatitis B （CHB） and non-alcoholic fatty liver disease （NAFLD）. Methods The clinical data of 225 patients with CHB complicated with NAFLD admitted to the Third People’ s Hospital of Kunming from January 1^st, 2020 to December 30^th, 2020 were retrospectively analyzed. According to the liver function, they were divided into group A （120 cases, no liver injury or mild liver injury） and group B （105 cases, moderate or severe liver injury）. The basic information, metabolism biomarkers, routine blood, renal functions and etiology markers of hepatitis B were used to perform an unifactor analysis. To explore the influencing factors of moderate or severe liver injury, binary logistic regression analysis were further performed. Results 1. There were significant differences in gender[group A vs. group B （the same as following）: proportion of males = 76.67% vs. 87.62%], HBeAg （+/-） [（HBeAg positive） = 49.17% vs. 53.91%], CHOL[（4.89±0.95） mmol/L vs.（4.23±1.17） mmol/L], HDL-C[1.10 （0.94～1.28） mmol/L vs. 0.90 （0.53～1.18） mmol/L], LDL-C[3.03 （2.52～3.60）mmol/L vs. 2.70 （2.05～3.19） mmol/L], PLT[（202.47±60.79）*10⁹/L vs.（173.37±60.89）*10⁹/L], BUN[4.51 （3.83～5.41） mmol/L vs. 3.92 （3.37～5.02） mmol/L], UA[369.00 （314.00～421.00） μmol/L vs. 338.50 （292.00～397.25） μmol/L], Ln （HBV-DNA） [12.79 （7.82～17.31） IU/mL vs. 15.44 （12.64～17.76） IU/mL] between two groups （P < 0.05）. 2. Binary Logisitic regression analysis showed that PLT[OR （95%CI） = 0.993 （0.987～0.999）], BUN[OR （95%CI） = 0.726 （0.565～0.932）], UA[OR （95%CI） = 0.994 （0.990～0.998）], HDL-C[OR （95%CI） = 0.175 （0.060～0.510）] were protective factors, with 1 unit decrease of which, the probability of moderate and severe liver injury increased by 0.7%, 27.4%, 0.6% and 82.5%, respectively; ; and HBV-DNA [OR （95%CI）=1.138 （1.045～1.239）] was a risk factor, the probability of moderate to severe liver damage increased by 13.8% with 1 unit increase of Ln （HBV-DNA）. Conclusion HBV-DNA, HDL-C, BUN, UA and PLT are influencing factors for moderate or severe liver injury in CHB patients with NAFLD and a higher attention should to be paid.
- Chronic hepatitis B,
- Nonalcoholic fatty liverdisease,
- Liver injury,
- Influencing factors

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References(18)

References

[1]	Hanif H,Khan M M,Ali M J,et al. A new endemic of concomitant nonalcoholic fatty liver disease and chronic hepatitis B[J]. Microorganisms,2020,8(10):1526. doi: 10.3390/microorganisms8101526
[2]	Hou C,Hua Z,Xu P,et al. Estimating the prevalence of hepatitis B by wastewater-based epidemiology in 19 cities in China[J]. Sci Total Environ,2020,740(10):139696.
[3]	Karacaer Z,Okur G,Cermik H,et al. Is there an influence of hepatic steatosis on fibrosis and necroinflammation in young patients with chronic viral hepatitis B?[J]. Postgrad Med,2016,128(7):697-700. doi: 10.1080/00325481.2016.1221733
[4]	Kim D S,Jeon M Y,Lee H W,et al. Influence of hepatic steatosis on the outcomes of patients with chronic hepatitis B treated with entecavir and tenofovir[J]. Clin Mol Hepatol,2019,25(3):283-293. doi: 10.3350/cmh.2018.0054
[5]	中华医学会肝病学分会脂肪肝和酒精性肝病学组,中国医师协会脂肪性肝病专家委员会. 酒精性肝病防治指南(2018年更新版)[J]. 临床肝胆病杂志,2018,34(5):939-946. doi: 10.3969/j.issn.1001-5256.2018.05.006
[6]	Schwimmer J B,Ugalde-Nicalo P,Welsh J A,et al. Effect of a low free sugar diet vs usual diet on nonalcoholic fatty liver disease in adolescent boys:a randomized clinical trial[J]. JAMA,2019,321(3):256-265. doi: 10.1001/jama.2018.20579
[7]	中华医学会感染病学分会,中华医学会肝病学会. 慢性乙型肝炎防治指南(2019年版)[J]. 临床肝胆病杂志,2019,35(12):2648-2669.
[8]	杨小琴. HBV感染者外周血单核细胞Toll样受体4表达及意义[D]. 昆明: 昆明医科大学硕士学位论文, 2012.
[9]	Wang F S,Fan J G,Zhang Z,et al. The global burden of liver disease:the major impact of China[J]. Hepatology,2014,60(6):2099-2108. doi: 10.1002/hep.27406
[10]	Sheka A C,Adeyi O,Thompson J,et al. Nonalcoholic steatohepatitis:a review[J]. JAMA,2020,323(12):1175-1183. doi: 10.1001/jama.2020.2298
[11]	Liu W,Baker R D,Bhatia T,et al. Pathogenesis of nonalcoholic steatohepatitis[J]. Cellular and molecular life sciences:CMLS,2016,73(10):1969-1987. doi: 10.1007/s00018-016-2161-x
[12]	Mak L Y,Hui R W,Fung J,et al. Diverse effects of hepatic steatosis on fibrosis progression and functional cure in virologically quiescent chronic hepatitis B[J]. J Hepatol,2020,73(4):800-806. doi: 10.1016/j.jhep.2020.05.040
[13]	Choi J S,Han K J,Lee S,et al. Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome in Korean adult men[J]. J Epidemiol,2015,25(1):74-79. doi: 10.2188/jea.JE20140053
[14]	莫小庆,黄春,宋青青,等. 2型糖尿病伴非酒精性脂肪肝患者胱抑素C与胰岛素抵抗的相关性研究[J]. 中国医药导报,2017,14(24):78-80.
[15]	Brunham L R,Hayden M R. Human genetics of HDL:Insight into particle metabolism and function[J]. Prog Lipid Res,2015,58(4):14-25.
[16]	Lin Y Y,Hu C T,Sun D S,et al. Thioacetamide-induced liver damage and thrombocytopenia is associated with induction of antiplatelet autoantibody in mice[J]. Sci Rep,2019,9(1):17497. doi: 10.1038/s41598-019-53977-7
[17]	谢放,孟庆华,侯维,等. HBeAg阳性慢性乙型肝炎合并非酒精性脂肪肝患者的临床与病理学特征[J]. 中华实验和临床感染病杂志(电子版),2018,12(3):256-261. doi: 10.3877/cma.j.issn.1674-1358.2018.03.011
[18]	Amin A A,Alabsawy E I,Jalan R,et al. Epidemiology,pathophysiology,and management of hepatorenal syndrome[J]. Semin Nephrol,2019,39(1):17-30. doi: 10.1016/j.semnephrol.2018.10.002

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