Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020

Hai-lin HUANG; Xiao-juan LI; Jian-wen YIN; Hong-chao JIANG

doi:10.12259/j.issn.2095-610X.S20210713

Volume 42 Issue 7

Jul. 2021

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Hai-lin HUANG, Xiao-juan LI, Jian-wen YIN, Hong-chao JIANG. Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020[J]. Journal of Kunming Medical University, 2021, 42(7): 83-87. doi: 10.12259/j.issn.2095-610X.S20210713

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Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020

doi: 10.12259/j.issn.2095-610X.S20210713

1.
Dept. of Clinical Laboratory，Kunming Children’s Hospital，Kunming Yunnan，650228
2.
Center for Disease Control of Yunnan Province，Kunming Yunnan 650118，China

Received Date: 2021-05-09
Publish Date: 2021-07-25

Abstract

Abstract

Objective To study the distribution and drug sensitivity of Salmonella and Shigella in bacterial infectious diarrhea in children in Kunming and provide reliable basis for clinical rational drug use. Methods Salmonella and Shigella were cultured from the fecal samples of children with diarrhea in Kunming children’ s Hospital from 2017 to 2020. The pathogens were identified by Vitek compact, an automatic bacterial analyzer, and their drug sensitivity was determined. The agglutination serotyping was completed. Finally, the original data were analyzed and statistically analyzed by WHONET 5.6 software. Results A total of 226 strains of Shigella and Salmonella were isolated from 29674 specimen in our hospital from 2017 to 2020, including 75 strains of Shigella （33.2%）, 33 strains of Shigella flexneri （14.6%）, 42 strains of Shigella sonnei （18.6%）, and no Shigella dysentery and Shigella baumannii were detected. 151 strains （66.8%） of Salmonella were isolated and 5 serotypes were detected, including 106 strains （46.9%） of Salmonella typhimurium and 25 strains （11.1%） of Salmonella typhimurium. The main distribution of infectious diarrhea in Kunming children is from April to October, and the aggregation distribution is from May to October. 72.8% （110/151） of the population under 2 years old were susceptible to Salmonella infection. Diarrhea caused by Salmonella infection in children in Kunming is increasing year by year, and Salmonella typhimurium is the main Salmonella. This study showed that Shigella flexneri was the main Shigella species in 2017 and 2018, and changed to Shigella sonnei after 2019. In addition, amoxicillin/clavulanic acid （82%） was the first choice for children with infectious diarrhea caused by Salmonella in Kunming, while ceftazidime （97.6%） and amoxicillin/clavulanic acid （92.8%） were the first choice for Shigella sonnei. The sensitivity rates of Shigella flexneri to ceftazidime and cefepime were only 60% and 40%, which suggested that the susceptibility of Shigella serogroups to antibiotics is different. No imipenem resistance was found in Salmonella and Shigella. Conclusions Salmonella and Shigella are the main infectious diarrhea pathogen in children, while Salmonella shows an increasing trend year by year. The incidence of diarrhea is higher over 2 years old. Salmonella typhimurium is the main serotype. Amoxicillin/clavulanic acid is the first choice for empirical use. The drug resistance of Shigella serotypes to antibiotics is different. Therefore, it is necessary to strengthen the monitoring of pathogenic bacteria and drug resistance in feces of diarrhea children, It is necessary to strengthen the surveillance of pathogens and drug resistance of stools in children with diarrhea so as to provide clinicians with targeted anti infective treatment according to the results of drug sensitivity.
- Children,
- Infectious diarrhea,
- Pathogens,
- Drug resistance rate

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