Changes of Rifampicin Concentration in Cerebrospinal Fluid of Patients with Tuberculous Meningoencephalitis

Yang LI; Hua HE; Yan-ling ZHANG; Ying HUANG; Jun-long WANG

doi:10.12259/j.issn.2095-610X.S20210718

Volume 42 Issue 7

Jul. 2021

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Yang LI, Hua HE, Yan-ling ZHANG, Ying HUANG, Jun-long WANG. Changes of Rifampicin Concentration in Cerebrospinal Fluid of Patients with Tuberculous Meningoencephalitis[J]. Journal of Kunming Medical University, 2021, 42(7): 110-114. doi: 10.12259/j.issn.2095-610X.S20210718

Citation:

Yang LI, Hua HE, Yan-ling ZHANG, Ying HUANG, Jun-long WANG. Changes of Rifampicin Concentration in Cerebrospinal Fluid of Patients with Tuberculous Meningoencephalitis[J]. Journal of Kunming Medical University, 2021, 42(7): 110-114. doi: 10.12259/j.issn.2095-610X.S20210718

Citation:

Yang LI, Hua HE, Yan-ling ZHANG, Ying HUANG, Jun-long WANG. Changes of Rifampicin Concentration in Cerebrospinal Fluid of Patients with Tuberculous Meningoencephalitis[J]. Journal of Kunming Medical University, 2021, 42(7): 110-114. doi: 10.12259/j.issn.2095-610X.S20210718

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Changes of Rifampicin Concentration in Cerebrospinal Fluid of Patients with Tuberculous Meningoencephalitis

doi: 10.12259/j.issn.2095-610X.S20210718

1.
Dept. of Infections Diseases
2.
Dept. of Pharmacyt，The 3rd People’s Hospital，Kumming Yunnan 650041，China

Received Date: 2021-04-07
Publish Date: 2021-07-25

Abstract

Abstract

Objective To investigate the concentration and efficacy of rifampicin （RIF） in cerebrospinal fluid during intrathecal injection of RIF in the treatment of tuberculous meningitis. Methods Forty patients with tuberculous meningitis were randomly divided into two groups according to the admission criteria, and both groups were given HRZE regimen, A1 group was non-intrathecal injection control group, A2 group was given intrathecal injection of rifampicin 40 mg + dexamethasone 2.5 mg once a day, and the concentration of RIF in blood and cerebrospinal fluid （expressed by bC_xh and cC_xh） was monitored at 0 h, 4 h and 8 h, respectively. Results At the 0th hour, the value of RIF in cerebrospinal fluid in A2 group was significantly higher than that in A1 group, P < 0.01. The concentration of rifampicin in serum reached the peak at 4 h, and the concentration of rifampicin in cerebrospinal fluid was higher at 8 h （cC _{8 h}）, 3.34 （1.03, 51.60） µg/mL, The results showed that there were significant differences in cC_{0 h}, cC_{4 h} and cC_{8 h} （P < 0.01）. Conclusions Intrathecal injection of RIF helps to increase the concentration of RIF in cerebrospinal fluid, and the curative effect is more significant. Intrathecal injection of Rifampin can keep the concentration of Rifampin at a high level at the 8th hour.
- Tuberculous meningoencephalitis,
- Rifampicin,
- Cerebrospinal fluid drug concentration,
- Blood drug concentration

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References(17)

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