Volume 42 Issue 7
Jul.  2021
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Article Navigation >  Journal of Kunming Medical University  > 2021  >  42(7): 130-136
Xiaoyue ZHOU, Ting YU. The Application of Narrative Education in the Clinical Teaching of Nursing Interns[J]. Journal of Kunming Medical University, 2024, 45(5): 190-194. doi: 10.12259/j.issn.2095-610X.S20240529
Citation: Yong-rui YANG, Hai-wen LI, Zhi-rong ZHAO, Lu WANG, Ting JIA, Zhi-jian DONG, Xiao-fei LI, Ni-hong LU. Clinical Efficacy and Safety of Sofosbuvir and Vipatavir in the Treatment of Patients with Chronic Hepatitis C and HCV/HIV co-infection[J]. Journal of Kunming Medical University, 2021, 42(7): 130-136. doi: 10.12259/j.issn.2095-610X.S20210722
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Clinical Efficacy and Safety of Sofosbuvir and Vipatavir in the Treatment of Patients with Chronic Hepatitis C and HCV/HIV co-infection

doi: 10.12259/j.issn.2095-610X.S20210722

  • Dept. of Hepatology，The 3rd People’s Hospital of Kunming/Yunnan Provincial Infectious Disease Clinical Medicine Center，Kunming Yunnan 650041，China

  • Received Date: 2021-04-25
    Available Online: 2021-07-19
  • Publish Date: 2021-07-21
    Abstract
  •   Objective  To observe the efficacy and safety of SofosbuvirVelpatasvir in the treatment to chronic hepatitis C combining with HCV/HIV.  Methods  419 patients with chronic hepatitis C and 56 patients with HCV/HIV that were admitted to Kunming Third People’ s Hospital were selected for this study. All kind of indicators such as virological response （SVR）, biochemical responses, and liver Fibrosis have been continuously monitored during the treatment of 4 weeks, 12 weeks, as well as additional 12th week follow-up after treatment termination.  Results  After 12-week treatment the genotype 1 patient solely with HCV has SVR12 of 97.56%; the genotype 2 patient has SVR12 of 98.97%; the genotype 3 patients has SVR12 of 97.54% while the genotype 6 has SVR12 of 97.85%, P = 0.870. In contrast, the patients with HCV/HIV co-infection were treated with SofosbuvirVelpatasvir besides their HIV treatment. After 12 weeks of the treatment, the genotype 1 patient showed SVR12 of 85.71%; the genotype 3 showed SVR12 of 92.11%; the genotype 6 shows SVR12 of 90.91%, P = 0.862. Also, after antiretroviral therapy both patients show the significant improvement in the biochemical indictors, AST, ALT and ALB as well as the renal function. The hepatic fibrosis index from both decreases significantly after the treatment. For the adverse reactions, diarrhea, nausea, vomiting and fatigue were found in GT3 genotype patients, while fatigue and headache were the most common in other genotypes patients and HCV/HIV co-infected patients.  Conclusion  Sofosbuvir and Vipatavir have high efficacy and good safety in the treatment to the patient with chronic hepatitis C and HCV/HIV co-infection.
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