The Correlation between Vitamin D Receptor Gene Bg1I and Cdx-2 Polymorphism and Hashimoto’ s Thyroiditis

Xiao-hui RUAN; Qian XIANG; Yu-ming WANG; Zhi-han ZHOU; Xian ZHANG; Yan GUO; Xiao-rui YANG

doi:10.12259/j.issn.2095-610X.S20210824

Volume 42 Issue 8

Aug. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(8): 132-139

Xiao-hui RUAN, Qian XIANG, Yu-ming WANG, Zhi-han ZHOU, Xian ZHANG, Yan GUO, Xiao-rui YANG. The Correlation between Vitamin D Receptor Gene Bg1I and Cdx-2 Polymorphism and Hashimoto’ s Thyroiditis[J]. Journal of Kunming Medical University, 2021, 42(8): 132-139. doi: 10.12259/j.issn.2095-610X.S20210824

Citation:

Xiao-hui RUAN, Qian XIANG, Yu-ming WANG, Zhi-han ZHOU, Xian ZHANG, Yan GUO, Xiao-rui YANG. The Correlation between Vitamin D Receptor Gene Bg1I and Cdx-2 Polymorphism and Hashimoto’ s Thyroiditis[J]. Journal of Kunming Medical University, 2021, 42(8): 132-139. doi: 10.12259/j.issn.2095-610X.S20210824

Citation:

Xiao-hui RUAN, Qian XIANG, Yu-ming WANG, Zhi-han ZHOU, Xian ZHANG, Yan GUO, Xiao-rui YANG. The Correlation between Vitamin D Receptor Gene Bg1I and Cdx-2 Polymorphism and Hashimoto’ s Thyroiditis[J]. Journal of Kunming Medical University, 2021, 42(8): 132-139. doi: 10.12259/j.issn.2095-610X.S20210824

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The Correlation between Vitamin D Receptor Gene Bg1I and Cdx-2 Polymorphism and Hashimoto’ s Thyroiditis

doi: 10.12259/j.issn.2095-610X.S20210824

1.
Dept. of Endocrinology，The 5th Affiliated Hospital of Kunming Medical University Yunnan/Honghe South Yunnan Central Hospital ，Gejiu Yunnan 661000
2.
Dept. of Clinical Laboratory，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
3.
Dept. of Nuclear Medicine，The 5th Affiliated Hospital of Kunming Medical University Yunnan/Honghe South Central Hospital Gejiu，Gejiu Yunnan 661000，China

Received Date: 2021-06-06
Available Online: 2021-08-04
Publish Date: 2021-08-04

Abstract

Abstract

Objective To investigate the correlation between Vitamin D receptor gene Bg1I, Cdx-2 polymorphism with Hashimoto’ s thyroiditis （HT）. Methods The SNP of VDR gene Bg1I and CDX-2 in 178 HT patients were detected by TaqMan fluorescent probe, including 56 patients with normal thyroid function （H0 group）, 80 patients with subclinical hypothyroidism （H1 group）, 42 patients with hypothyroidism （H2 group） and 64 healthy controls （NT group）. The genotype frequency, allele frequency and related clinical data were compared and analyzed. Results Bg1I GG, GT and TT genotypes frequencies were 0.500, 0.405 and 0.095, respectively; alleles G and T were 0.7025 and 0.2975, respectively. CDX-2 GG, GA and AA genotypes frequencies were 0.2934, 0.5289 and 0.1777, respectively; alleles G and A frequencies were 0.5579 and 0.4421, respectively. The genotype frequency and allele frequency in two groups were not significantly different （P > 0.05）. Logistic regression analysis indicated 25 （OH） D deficiency might be an independent risk factor for HT （OR = 1.573, P = 0.046）; male （OR = 0.158, P < 0.001） and CDX-2 G genotype （OR = 0.301, P = 0.035） may be protective factors for hypothyroidism in HT patients. High titrate TPO-Ab （OR = 1.639, P = 0.045） and TG-Ab （OR = 1.779, P = 0.035） may be risk factors for hypothyroidism in HT patients. Conclusion （1）Single nucleotide polymorphisms （SNPs） were found at VDR BG1I and CDX-2 sites. （2）CDX-2 G genotype may be a protective factor of hypothyroidism in HT. （3）Bg1I single nucleotide polymorphism was not related to the occurrence and progression of HT.
- Vitamin D receptor gene,
- Single nucleotide polymorphism,
- 25 hydroxyvitamin D,
- Hashimoto’ s thyroiditis,
- Hypothyroidism

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