Expression and Significance of TGF - β 1，TIMP-1 and Collagen Ⅲ in Vaginal Wall of Patients with Pelvic Organ Prolapse

Zhi-hong LI; Yong HU; Zheng-hua XIONG; Xi-cui LONG; Shao-bo LU; Xue-song HAN

doi:10.12259/j.issn.2095-610X.S20210909

Volume 42 Issue 9

Sep. 2021

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Zhi-hong LI, Yong HU, Zheng-hua XIONG, Xi-cui LONG, Shao-bo LU, Xue-song HAN. Expression and Significance of TGF - β 1，TIMP-1 and Collagen Ⅲ in Vaginal Wall of Patients with Pelvic Organ Prolapse[J]. Journal of Kunming Medical University, 2021, 42(9): 95-100. doi: 10.12259/j.issn.2095-610X.S20210909

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Expression and Significance of TGF - β 1，TIMP-1 and Collagen Ⅲ in Vaginal Wall of Patients with Pelvic Organ Prolapse

doi: 10.12259/j.issn.2095-610X.S20210909

Dept. of Obstetrics and Gynecology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-07-11
Available Online: 2021-09-13
Publish Date: 2021-09-30

Abstract

Abstract

Objective To investigate the expression and significance of TGF-β1, TIMP-1 and Collagen Ⅲ in the vaginal wall of patients with pelvic organ prolapse （POP）. Methods A total of 28 POP patients who underwent surgery in the Department of Gynecology of the First Affiliated Hospital of Kunming Medical University from March 2020 to December 2020 were selected as the POP group, which were divided into 7 cases of grade Ⅱ, 16 cases of grade Ⅲ, and 5 cases of grade Ⅳ according to POP-Q staging method. Thirty patients with complete hysterectomy and/or bilateral adnexectomy without POP due to gynecological benign lesions were selected as the control group. The expressions of TGF-β1, TIMP-1 and Collagen Ⅲ in vaginal wall tissue were identified by immunohistochemistry. Results The IRS score of TGF-β1, TIMP-1 and Collagen Ⅲ in the POP group were significantly lower than those in the control group, with the statistical significance （P < 0.05）. The IRS scores of TGF-β1, TIMP-1 and collagen Ⅲ in patients with grade Ⅱ, grade Ⅲ and grade Ⅳ in the POP group gradually decreased with the increase of degree, and the differences were statistically significant （P < 0.05）. There was a positive correlation between TIMP-1 and TGF-β1 expression in the vaginal wall tissue of the POP group （r = 0.381, 0.519, P < 0.05）. TGF-β1 expression was positively correlated with TIMP-1 expression （r = 0.270, P < 0.05）. Conclusion Collagen Ⅲ, TIMP-1 and TGF-β1 are low expressed in vaginal wall tissue of pop patients, which may be involved in the occurrence and development of pop, and may be correlated with the severity of the disease. Collagen Ⅲ, TIMP-1 and TGF-β1 in the vaginal wall tissue of pop patients are correlated to some extent, and they have a certain synergistic effect, jointly participating in the occurrence and development of the disease.
- Transforming growth factor-β1,
- Tissue matrix metalloproteinase inhibitor-1,
- Collagen Ⅲ,
- Pelvic organ prolapse

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