Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury

Sai-ge YIN; Jun SUN; Xin-wang YANG

doi:10.12259/j.issn.2095-610X.S20210929

Volume 42 Issue 9

Sep. 2021

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Sai-ge YIN, Jun SUN, Xin-wang YANG. Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury[J]. Journal of Kunming Medical University, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929

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Sai-ge YIN, Jun SUN, Xin-wang YANG. Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury[J]. Journal of Kunming Medical University, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929

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Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury

doi: 10.12259/j.issn.2095-610X.S20210929

Dept. of Anatomy and Histology & Embryology，Faculty of Basic Medical Science， Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2021-06-13
Available Online: 2021-09-28
Publish Date: 2021-09-30

Abstract

Abstract

Ischemic stroke （IS） is one of the main causes of long-term and severe disability due to its high incidence rate, mortality rate, disability rate, and recurrence rate. At present, there is only the only approved recombinant tissue-type plasminogen activator for the treatment of is in the clinic. However, due to its narrow time window and many relative contraindications, the clinical medication is greatly limited. Therefore, the development of new and efficient is neuroprotective drugs has important clinical significance. In recent years, peptide molecular have attracted extensive attention due to their low toxicity, high targeting, and specificity. The prevention and treatment effect of exogenous peptide molecular on IS has also been reported. In this paper, we reviewed the preventive and therapeutic effects and mechanisms of various peptide molecule on IS and provided new molecular biological templates and research ideas for the development of new and efficient neuroprotective drugs for IS.
- Peptide drugs,
- Ischemic stroke,
- Neuroprotection,
- Exogenous application

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References(41)

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