Correlation of Platelet Function，Coagulation and Fibrinolytic System Function in Elderly Patients with Type 2 Diabetes

Lin ZHANG; Yan-ying LI; Qi MENG; Can-hui LI; Yun SHEN; Hong-yan BI; Qiu-ping YANG; Yue XIONG

doi:10.12259/j.issn.2095-610X.S20211110

Volume 42 Issue 11

Nov. 2021

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Lin ZHANG, Yan-ying LI, Qi MENG, Can-hui LI, Yun SHEN, Hong-yan BI, Qiu-ping YANG, Yue XIONG. Correlation of Platelet Function，Coagulation and Fibrinolytic System Function in Elderly Patients with Type 2 Diabetes[J]. Journal of Kunming Medical University, 2021, 42(11): 62-67. doi: 10.12259/j.issn.2095-610X.S20211110

Citation:

Lin ZHANG, Yan-ying LI, Qi MENG, Can-hui LI, Yun SHEN, Hong-yan BI, Qiu-ping YANG, Yue XIONG. Correlation of Platelet Function，Coagulation and Fibrinolytic System Function in Elderly Patients with Type 2 Diabetes[J]. Journal of Kunming Medical University, 2021, 42(11): 62-67. doi: 10.12259/j.issn.2095-610X.S20211110

Citation:

Lin ZHANG, Yan-ying LI, Qi MENG, Can-hui LI, Yun SHEN, Hong-yan BI, Qiu-ping YANG, Yue XIONG. Correlation of Platelet Function，Coagulation and Fibrinolytic System Function in Elderly Patients with Type 2 Diabetes[J]. Journal of Kunming Medical University, 2021, 42(11): 62-67. doi: 10.12259/j.issn.2095-610X.S20211110

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Correlation of Platelet Function，Coagulation and Fibrinolytic System Function in Elderly Patients with Type 2 Diabetes

doi: 10.12259/j.issn.2095-610X.S20211110

1.
Dept. of General Medicine
2.
Geriatrics Department，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-09-26
Available Online: 2021-11-15
Publish Date: 2021-11-30

Abstract

Abstract

Objective To investigate the platelet function, coagulation function and fibrinolytic system in elderly patients with type 2 diabetes. Methods 193 patients were divided into type 2 diabetes group （group DM, 97 cases） and control group （group NC, 96 cases） according to WHO standard diagnostic criteria.The gender, age, duration of diabetes, smoking history, SBP, DBP, BMI, FPG, 2 h PG, HbA1c, FC, TC, TG, ACT, PF, and aggregation polymer were collected and compared among the patients. Pearson correlation analysis and multiple linear regression analysis were performed on the related factors of PF and D-2 polymer. Results （1） The levels of BMI, D-2 polymer and ACT in the DM group were higher than those in the control group （P < 0.05）. （2） Pearson correlation analysis: The value of D-2 aggregate was positively correlated with age, BMI, and duration of diabetes （P < 0.05）, and positively correlated with the percentage of glycosylated hemoglobin （P < 0.01）. PF had significant negative correlation with the levels of 2 h postprandial insulin and C peptide （P < 0.05）, and more significant positive correlation with fasting blood glucose （P < 0.01）. （3） Multiple linear regression analysis: age and percentage of glycosylated hemoglobin were positively correlated with D-2 polymer （P < 0.05）. There was a positive correlation between fasting blood glucose and PF, and a negative correlation between insulin and PF at 2 hours after meal （P < 0.05）. Conclusion There are abnormal platelet function, coagulation function and fibrous function system in elderly patients with type 2 diabetes mellitus, high state of blood glucose and poor function of isolated islets may be the main reasons.
- Elderly type 2 diabetes mellitus,
- Platelet function,
- Coagulation function,
- Fibrinolytic system function

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References(21)

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