Value of Color Doppler Ultrasonography, Fine Needle Aspiration Cytology, and the Level of Thyroglobulin in the Diagnosis of Cervical Lymph Node Metastasis of Papillary Thyroid Carcinoma

Ya CAO; Hui ZHANG; Lin MENG; Huan-ran NI; Yi ZHAO; Guang-yan WANG; Zhi-ying LIU; Xiao-mei YANG; Li-chun YANG

doi:10.12259/j.issn.2095-610X.S20211119

Volume 42 Issue 11

Nov. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(11): 105-110

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Ya CAO, Hui ZHANG, Lin MENG, Huan-ran NI, Yi ZHAO, Guang-yan WANG, Zhi-ying LIU, Xiao-mei YANG, Li-chun YANG. Value of Color Doppler Ultrasonography, Fine Needle Aspiration Cytology, and the Level of Thyroglobulin in the Diagnosis of Cervical Lymph Node Metastasis of Papillary Thyroid Carcinoma[J]. Journal of Kunming Medical University, 2021, 42(11): 105-110. doi: 10.12259/j.issn.2095-610X.S20211119

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Value of Color Doppler Ultrasonography, Fine Needle Aspiration Cytology, and the Level of Thyroglobulin in the Diagnosis of Cervical Lymph Node Metastasis of Papillary Thyroid Carcinoma

doi: 10.12259/j.issn.2095-610X.S20211119

1.
Dept. of Ultrasound Medicine
2.
Dept. of Hepatobiliary Surgery
3.
Dept. of General Practice
4.
Dept. of Pathology
5.
Dept. of Laboratory，The People’s Hospital of Chuxiong Yi Autonomo CDU Prefecture/The 4th Affiliated Hospital of Dali University，Chuxiong Yunnan 675000
6.
Dept. of Ultrasound Medicine， Yunnan Cancer Hospital，Kunming Yunnan 650118，China

Received Date: 2021-09-25
Available Online: 2021-11-16
Publish Date: 2021-11-30

Abstract

Abstract

Objective To explore the value of color Doppler ultrasonography （CDU） signs, fine needle aspiration cytology （FNA-C） of lymph nodes, and the level of thyroglobulin in lymph node fine needle aspiration eluate （FNA-Tg） in the diagnosis of cervical lymph node metastasis of papillary thyroid carcinoma （PTC）. Methods Firstly, CDU signs of cervical lymph nodes, FNA-C, FNA-Tg level, preoperative serum Tg level, and postoperative pathological results of patients with PTC were retrospectively analyzed and the specificity and positive prediction rate of them were also analyzed. Then, the receiver operating characteristic （ROC） curve and the optimal diagnostic threshold of FNA-Tg levels were determined. After that, the correlation between preoperative serum Tg, thyroid-stimulating hormone （TSH）, serum Tg antibody （TGAB） and lymph node FNA-Tg level were analyzed. Results As a result, in patients with typical ultrasound signs of cervical lymph node metastasis, the diagnostic rate of FNA-Tg was 100%, which is better than CDU and FNA-C. the cortical thickness of cervical lymph nodes is uneven and is ≥ 2mm, the diagnostic rate of FNA-Tg was 88.9%. The threshold value of FNA-Tg level in lymph nodes for diagnosing cervical lymph node metastasis of PTC was 2.57 ng/ml. There was no correlation between lymph node FNA-Tg and serum Tg level, serum TGAB （P > 0.05）, while there was a correlation between lymph node FNA-Tg and TSH （P < 0.05）. Conclusions For PTC patients with typical signs of cervical lymph node metastasis showed by CDU, the combination of CDU signs, lymph node FNA-C and FNA-Tg can accurately diagnose cervical lymph node metastasis. Attention should be paid to PTC patients with atypical signs of cervical lymph node metastasis （uneven cortical thickness ≥ 2 mm） showed by CDU, Lymph node lymph node FNA-C and FNA-Tg can significantly improve the diagnostic rate and form an important basis for clinical treatment of cervical lymph node metastasis in PTC patients.
- Cervical lymph node,
- Color Doppler ultrasonography,
- Fine needle aspiration cytology,
- FNA-Tg

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