Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation

Zhong FANG; Xiao-dong XU; Li-hua WANG; Ying ZHANG; Chao MA

doi:10.12259/j.issn.2095-610X.S20211120

Volume 42 Issue 11

Nov. 2021

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Zhong FANG, Xiao-dong XU, Li-hua WANG, Ying ZHANG, Chao MA. Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation[J]. Journal of Kunming Medical University, 2021, 42(11): 111-116. doi: 10.12259/j.issn.2095-610X.S20211120

Citation:

Zhong FANG, Xiao-dong XU, Li-hua WANG, Ying ZHANG, Chao MA. Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation[J]. Journal of Kunming Medical University, 2021, 42(11): 111-116. doi: 10.12259/j.issn.2095-610X.S20211120

Citation:

Zhong FANG, Xiao-dong XU, Li-hua WANG, Ying ZHANG, Chao MA. Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation[J]. Journal of Kunming Medical University, 2021, 42(11): 111-116. doi: 10.12259/j.issn.2095-610X.S20211120

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Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation

doi: 10.12259/j.issn.2095-610X.S20211120

Dept. of Cardiology，The People’s Hospital of Chizhou，Chizhou Anhui 247000，China

Received Date: 2021-09-07
Available Online: 2021-11-16
Publish Date: 2021-11-30

Abstract

Abstract

Objective To investigate the prognostic value of eGFR and serum NT-proBNP in patients with chronic heart failure complicated with atrial fibrillation. Methods From January 2018 to December 2019, 139 hospitalized patients with chronic heart failure complicated with atrial fibrillation were selected. The serum creatinine and NT-proBNP of the patients were measured, and the estimated glomerular filtration rate （eGFR） of the patients was calculated according to theequationofModification of Diet in Renal Disease. All-cause deaths after discharge were followed up. Logistic regression was used to analyze the risk factors of all-cause death in chronic heart failure complicated with atrial fibrillation during the follow-up period. ROC curve was used to analyze the prognostic value of eGFR and serum NT-proBNP in patients with chronic heart failure complicated with atrial fibrillation.Kaplan-meier method was used to draw the survival curve, and log-rank test was used for survival analysis. Results During the follow-up, 65 patients were found dead. The incidence was 46.76%. The area under the curve of eGFR-in predicting the absence of all-cause death in patients with chronic heart failure and atrial fibrillation was 0.651 （95%CI: 0.562 ～ 0.740）.The sensitivity was 57.70%, and the specificity was 69.20%. The area under the curve of serum NT-proBNP for predicting all-cause death in patients with chronic heart failure complicated with atrial fibrillation was 0.720 （95%CI: 0.638 ～ 0.803）.The sensitivity was 69.20%, and the specificity was 67.30%. The cumulative survival rate of patients in the low-eGFR group was significantly lower than that in the high-eGFR group during follow-up. The Log-rank value was 9.21, P = 0.002. During the follow-up, the cumulative survival rate of patients in the high level of NT-proBNP group was significantly lower than that in the low level of NT-proBNP group. The statistical value of Log-rank test was 16.91, P < 0.001. Conclusion eGFR and serum NT-proBNP have certain predictive value for the short-term prognosis of patients with chronic heart failure complicated with atrial fibrillation.
- Chronicheart failure,
- Atrial fibrillation,
- Evaluate glomerular filtration rate,
- N-terminal probrain natriuretic peptide,
- Prognosis

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References(24)

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