Clinical Analysis of Peripheral Blood Cells and Coagulation Function in Patients with Adenomyosis

Fan XU; Fang-yuan GUO; Yan HE; Xiang-qun WEI

doi:10.12259/j.issn.2095-610X.S20211124

Volume 42 Issue 11

Nov. 2021

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Fan XU, Fang-yuan GUO, Yan HE, Xiang-qun WEI. Clinical Analysis of Peripheral Blood Cells and Coagulation Function in Patients with Adenomyosis[J]. Journal of Kunming Medical University, 2021, 42(11): 128-133. doi: 10.12259/j.issn.2095-610X.S20211124

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Fan XU, Fang-yuan GUO, Yan HE, Xiang-qun WEI. Clinical Analysis of Peripheral Blood Cells and Coagulation Function in Patients with Adenomyosis[J]. Journal of Kunming Medical University, 2021, 42(11): 128-133. doi: 10.12259/j.issn.2095-610X.S20211124

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Clinical Analysis of Peripheral Blood Cells and Coagulation Function in Patients with Adenomyosis

doi: 10.12259/j.issn.2095-610X.S20211124

Dept. of Gynecology，The Affiliated Hospital of Yunnan University， Kunming Yunnan 650021，China

Received Date: 2021-09-02
Available Online: 2021-11-16
Publish Date: 2021-11-30

Abstract

Abstract

Objective To investigate the changes of peripheral blood cells and their derived parameters and coagulation function in patients with adenomyosis, and to study the diagnostic value and clinical significance of the changes in adenomyosis. Methods The clinical data of 116 patients with adenomyosis （adenomyosis group） and 106 patients with benign ovarian cyst （control group） admitted to the Affiliated Hospital of Yunnan University from January 2010 to December 2020 are selected to compare the two groups Changes in peripheral blood cells, systemic immune inflammatory index （SII）, system-wide inflammatory response index （SIRI）, blood coagulation function and serum carbohydrate antigen 125 （CA125） and CA199 in patients’ peripheral blood cells, and plotting receiver operating characteristics （ROC） curve, calculate the area under the curve （AUC） of each parameter, and analyze its clinical significance in adenomyosis. Results （1） The uterine volume of adenomyosis group is （331.86±237.20） cm³ higher than that of control group （50.30±23.74） cm³ （P < 0.05）; （2）The levels of WBC, neutrophils, platelets, SII and SIRI in adenomyosis group [（6.65±2.41）×10⁹/L; （4.31±2.10）×10⁹/L; （298.33±80.09）×10⁹/L; （802.45±622. 22）; 1.34±1.70] is significantly higher than the control group [（5.93±1.30） x10⁹/L, （3.60±0.89） x 10⁹/L, （222.42±41.59） x 10⁹/L, 456.36±138.98; 456.36±138.98]（P < 0.05）; （3）The levels of CA125 （139.96±119.42KU/L） and CA199 （73.93±123.66KU/L） in peripheral blood of patients with adenomyosis are significantly higher than those in control group （10.98±8.72）; 14.30±7.98）（P < 0.05）; （4）Prothrombin time （PT）（11.11±0.67s） and activated partial thromboplastin time （APTT）（24.78±3.52s） in adenomyosis group are shorter than those in control group （11.34±0.65s）; 27.4±2.79s）（P < 0.05）; （5） AUC of WBC, NEU, PLT, SII, SIRI, CA125, CA199, PT and APTT are 0.5658, 0.5629, 0.7901, 0.7307, 0.5836, 0.9569, 0.7971, 0.6082, 0.7596 respectively. Conclusions The number of peripheral blood inflammatory cells in adenomyosis patients is increasing, and there are abnormal blood coagulation function. CA125 has high diagnostic value for adenomyosis.PLT, SII, CA199 and APTT also have certain accuracy in the diagnosis of adenomyosis.
- Adenomyosis,
- Inflammation,
- Blood coagulation

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