Correlation Analysis of Antimicrobial Use and Common Bacterial Resistance in a Hospital in Yunnan From 2016 to 2019

Pu-mei CUI; Tai-fang CHEN; Chao CHEN; Yong-mei LIANG; Yue XU

doi:10.12259/j.issn.2095-610X.S20211127

Volume 42 Issue 11

Nov. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(11): 140-147

Pu-mei CUI, Tai-fang CHEN, Chao CHEN, Yong-mei LIANG, Yue XU. Correlation Analysis of Antimicrobial Use and Common Bacterial Resistance in a Hospital in Yunnan From 2016 to 2019[J]. Journal of Kunming Medical University, 2021, 42(11): 140-147. doi: 10.12259/j.issn.2095-610X.S20211127

Citation:

Pu-mei CUI, Tai-fang CHEN, Chao CHEN, Yong-mei LIANG, Yue XU. Correlation Analysis of Antimicrobial Use and Common Bacterial Resistance in a Hospital in Yunnan From 2016 to 2019[J]. Journal of Kunming Medical University, 2021, 42(11): 140-147. doi: 10.12259/j.issn.2095-610X.S20211127

Citation:

Pu-mei CUI, Tai-fang CHEN, Chao CHEN, Yong-mei LIANG, Yue XU. Correlation Analysis of Antimicrobial Use and Common Bacterial Resistance in a Hospital in Yunnan From 2016 to 2019[J]. Journal of Kunming Medical University, 2021, 42(11): 140-147. doi: 10.12259/j.issn.2095-610X.S20211127

PDF( 645 KB)

Correlation Analysis of Antimicrobial Use and Common Bacterial Resistance in a Hospital in Yunnan From 2016 to 2019

doi: 10.12259/j.issn.2095-610X.S20211127

1.
Dept. of Pharmacy
2.
Dept. of Clinical Laboratory
3.
Dept. of Oncology，The Anning First People’s Hospital，Kunming Yunnan 650302，China

Received Date: 2021-09-13
Publish Date: 2021-11-25

Abstract

Abstract

Objective To investigate the correlation between antimicrobial drug use and bacterial drug resistance, and to provide reference basis for clinical rational use of antimicrobial drugs. Methods DDDs and AUD of antimicrobial in Anning First People’ s Hospital from 2016 to 2019 were analyzed. WHONET5.6 software was used to calculate the drug resistance rate of bacteria isolated from clinical samples in the same period, and SPSS 23.0 software was used to analyze the correlation between the frequency of antimicrobial use and bacterial resistance. Results The usage of three generations of cephalosporins and quinolones in our hospital ranked the top, and the top 5 pathogens detected in clinical specimens were Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis and Acinetobacter baumannii. The drug resistance rate of Escherichia coli was correlated with the DDDs of amikacin （r = -0.959, P = 0.041）, Klebsiella pneumoniae was correlated with ceftazidime DDDs （ r = 0.999, P = 0.001）, Acinetobacter baumannii and Pseudomonas aeruginosa resistance rates were correlated with DDDs of imipenancetastatin （r = 0.999, P = 0.001 and r = 0. 967 , P = 0.033）, Streptococcus pneumoniae resistance rates were correlated with DDDs of moxifloxacin （r = 0.989, P = 0.011）. Conclusions There is a correlation between the amount of antimicrobial agents and bacterial drug resistance, so it is necessary to select antimicrobial agents according to the results of drug sensitivity test to reduce the bacterial resistance.
- Antimicrobial agents,
- Bacterial resistance,
- Correlation,
- Drug sensitive test

FullText(HTML)

References(18)

References

[1]	Lucy McDonnell,David Armstrong,Mark Ashworth,et al. National disparities in the relationship between antimicrobial resistance and antimicrobial consumption in Europe:an observational study in 29 countries[J]. J Antimicrob Chemother,2017,72(25):3199-3204.
[2]	尚红, 王毓三, 申子瑜, 等. 全国临床检验操作规程[M]. 第4版. 北京: 人民卫生出版社, 2015: 640.
[3]	WS/T978-2020. Performance Standards for Antimicr obial Susceptibility Testing[S]. USA: Clinical and Laboratory Standards Institute, 2020.
[4]	王强, 金岩, 李婉. 药品的解剖学治疗学化学分类索引及规定日剂量[M]. 北京: 中国协和医科大学出版社, 2003: 105-125.
[5]	陈新谦, 金有豫, 汤光. 新编药物学[M]. 第18版. 北京: 人民卫生出版社, 2017: 39-183.
[6]	陈约慧,应芙蓉,詹玲玲,等. 1543株铜绿假单胞菌感染的临床分布及耐药性分析[J]. 中国临床药理学杂志,2018,34(24):2514-2817.
[7]	王鼎盛,杨学军,杨丽娟,等. 我院2010-2014年抗菌药物应用与细菌耐药情况的相关性分析[J]. 中国药房,2016,27(14):1915-1918. doi: 10.6039/j.issn.1001-0408.2016.14.13
[8]	范利红,苗彩云,邵淑容,等. 2010-2014年医院大肠埃希菌耐药性变迁与抗菌药物使用频度相关性分析[J]. 中华医院感染学杂志,2017,27(1):20-23.
[9]	张青,马慧娜. 大肠埃希菌生物膜形成与耐药机制的研究进展[J]. 中国抗生素杂志,2018,43(5):497-501. doi: 10.3969/j.issn.1001-8689.2018.05.001
[10]	王美玲. 2016-2018年我院抗菌药物的使用及细菌耐药性的分析[J]. 西北药学杂志,2020,35(2):304-308. doi: 10.3969/j.issn.1004-2407.2020.02.033
[11]	黎小妍,陆英,李炫城,等. 环丙沙星药物使用频度与细菌耐药性的相关性分析[J]. 中国微生态学杂志,2016,28(10):1165-1167.
[12]	胡付品,郭燕,朱德妹,等. 2017年CHINET中国细菌耐药性监测[J]. 中国感染与化疗杂志,2018,18(3):241-251.
[13]	盛雪鹤,许锦英,王幼林,等. 某三级医院常见细菌耐药性与抗菌药物使用相关性分析[J]. 中国临床药理学与治疗学,2019,24(7):778-785. doi: 10.12092/j.issn.1009-2501.2019.07.009
[14]	杨柳,张志洁,秦晓松. 肺炎克雷伯菌对碳青酶烯类的耐药机制和危险因素[J]. 中国抗生素杂志,2018,43(2):163-168. doi: 10.3969/j.issn.1001-8689.2018.02.008
[15]	国家卫生计生委合理用药专家委员会. 耐药革兰阴性菌感染诊疗手册[M]. 北京: 人民卫生出版社, 2015: 84-85.
[16]	陈代杰. 从靶标到网络-抗菌药物作用机制与细菌耐药机制的研究进展[J]. 中国感染与化疗杂志,2015,15(1):84-88. doi: 10.3969/j.issn.1009-7708.2015.01.025
[17]	陈华栋,张尚鹏,徐星娥,等. 细菌耐药性发展与抗菌药物使用的量效关系[J]. 中国医院感染学杂志,2012,2(7):1538-1540.
[18]	吴昭漩. 大肠埃希菌耐药性与5种头孢菌素用量变化的灰色关联分析[J]. 医药导报,2010,29(4):533-537. doi: 10.3870/yydb.2010.04.046

Relative Articles(20)

Relative Articles

[1]	Xuelin ZHANG, Lu LIU, Yanzhi CHEN, Caijun ZHA, Yanli LI. The Distribution and Drug Resistance of Pathogenic Bacteria in Respiratory Tract Infections in Children from 2019 to 2022. Journal of Kunming Medical University, 2024, 45(1): 149-155. doi: 10.12259/j.issn.2095-610X.S20240125
[2]	Jianheng AO, Lei MIAO, Huiying WANG, Tianyun ZHANG, Tao WANG, Yonghang TANG, Liping HU, Shengjie NIE. Correlation between DNA Detection Rate and Sweat Pore Density of Palm Touch Biological Samples. Journal of Kunming Medical University, 2023, 44(6): 136-142. doi: 10.12259/j.issn.2095-610X.S20230601
[3]	Xiaohua LU, Hongxin YUAN. The Analysis of the Correlation between BTLA，CTLA-4 Gene Polymorphisms and the Efficacy and Prognosis of TACE Combined Targeted Therapy for Liver Cancer. Journal of Kunming Medical University, 2023, 44(9): 126-135. doi: 10.12259/j.issn.2095-610X.S20230927
[4]	Rong LIU, Yang SUN, Fameng LUO, Dezhi TAO, Haiyan ZHANG. Correlation between the Acceptance of Illness and Quality of Life in Patients with Inflammatory Bowel Disease. Journal of Kunming Medical University, 2022, 43(5): 173-178. doi: 10.12259/j.issn.2095-610X.S20220507
[5]	Yanfen MA, Jian HU, Depei CAI, Yongfeng QIAO, Xiaoqin WANG. Correlation between Serum Gamma-glutamyl Transferase Level and Blood Lipid Indexes in 3137 Checkup Population. Journal of Kunming Medical University, 2022, 43(10): 115-121. doi: 10.12259/j.issn.2095-610X.S20221001
[6]	Jinyi GU, Deyao DENG, Wenli YUAN, Qiuping YANG, Jianmei SONG, Yanjun SHEN, Yuanyuan GUO, Hongyun XU. Clinical Distribution and Drug Resistance Analysis of Acineto Bacterbaumannii from 2014 to 2020. Journal of Kunming Medical University, 2022, 43(5): 83-87. doi: 10.12259/j.issn.2095-610X.S20220504
[7]	Xueting YANG, Huifeng ZHANG. Evaluation of Drug Utilization in the Infected Patients with ESBLs Produced by Enterobacteriaceaein. Journal of Kunming Medical University, 2022, 43(6): 74-78. doi: 10.12259/j.issn.2095-610X.S20220621
[8]	Xin WU, Yun LI, Pin-fei ZOU, Mei-ling LI, Yong-bin PU. The Detection Rate of Musculoskeletal Ultrasound in Patients with Rheumatic Knee Arthritis and Its Correlation with Knee Function. Journal of Kunming Medical University, 2021, 42(8): 78-82. doi: 10.12259/j.issn.2095-610X.S20210814
[9]	Ying HUANG, Xiang LI, Shan JIANG, Bing LIU, Yan-ling ZHANG, Yang LI, Hua HE, Yan WU, Yun LUO, Jun XU. Correlation Analysis of Chest Imaging and Laboratory Indicators in Patients with 2019-nCoV Infection. Journal of Kunming Medical University, 2021, 42(12): 129-134. doi: 10.12259/j.issn.2095-610X.S20211232
[10]	Juan-juan WANG, Yu-qing CHEN, Qian DENG, Jian GAO. The Correlation between Myocardial Enzymes and the Severity of Ketoacidosis in Children with Type 1 Diabetes. Journal of Kunming Medical University, 2021, 42(1): 147-151. doi: 10.12259/j.issn.2095-610X.S20210129
[11]	Fu Yan , Li Xin Yi , Yuan Yong , Wang Wei Hua . . Journal of Kunming Medical University, 2019, 40(06): 121-124.
[12]	Zhao Xiao Li . . Journal of Kunming Medical University,
[13]	Fu Yuan Chun . . Journal of Kunming Medical University,
[14]	Mei Xue . . Journal of Kunming Medical University,
[15]	Zhao Jin You . . Journal of Kunming Medical University,
[16]	Zheng Hong Mei . . Journal of Kunming Medical University,
[17]	Qi Yan Wei . 云南省HIV/AIDS患者下呼吸道感染病原菌分布及耐药分析. Journal of Kunming Medical University,
[18]	Mao Jian . . Journal of Kunming Medical University,
[19]	Chen Rui Chun . . Journal of Kunming Medical University,
[20]	Zhou Shi Qiao . . Journal of Kunming Medical University,