Analysis of Influencing Factors of Early Rejection after Heart Transplantation

Li SHUAI; Xiao-ye FU; Jie WEI; Xiao MA; Lv ZHOU; Xi-lin KANG

doi:10.12259/j.issn.2095-610X.S20220122

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > Accepted Manuscript

Li SHUAI, Xiao-ye FU, Jie WEI, Xiao MA, Lv ZHOU, Xi-lin KANG. Analysis of Influencing Factors of Early Rejection after Heart Transplantation[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S20220122

Citation:

Li SHUAI, Xiao-ye FU, Jie WEI, Xiao MA, Lv ZHOU, Xi-lin KANG. Analysis of Influencing Factors of Early Rejection after Heart Transplantation[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S20220122

Citation:

PDF( 633 KB)

Analysis of Influencing Factors of Early Rejection after Heart Transplantation

doi: 10.12259/j.issn.2095-610X.S20220122

1.
Dept. of Blood Transfusion
2.
Dept. of Heart Vascular Surgery，Yan’an Hospital Affiliated of Kunming Medical University，Kunming Yunnan 650051，China

Received Date: 2021-12-11
Available Online: 2021-12-20

Abstract

Abstract

Objective To analyze and explore the relationship between HLA matching and acute rejection after the heart transplantation. Methods From May 2003 to January 2021, 24 patients who underwent heart transplantation in Yan’an Hospital affiliated to Kunming Medical University were included as the research subjects. Follow-up observations were made on the early curative effect and rejection of patients 3 to 12 months after transplantation. HLA typing was performed by PCR-SSP and the forward stepwise （conditional） method of SPSS statistics 17.0 software was used for binary logistic regression to analyze the influencing factors of acute rejection in heart transplantation patients. Results For the HLA six-antigen matching between the 24 donors and recipients of heart transplantation, the rejection rate was lower when the number of mismatches was less than 3 to 4 compared with the number of mismatches of 5 or 6 antigens （P < 0.05） The difference was statistically significant. According to the principle of ABO blood group compatibility, in 2 cases of type O donor heart transplantation to type A recipients, both of the 2 cases had the early rejection, while 3 of the 7 donors and recipients of different genders had the early rejection. Conclusion Many factors can cause the rejection of heart transplantation, and the number of HLA six antigen mismatches is one of the important factors for the rejection of heart transplantation.
- Heart transplantation,
- HLA matching,
- Blood type,
- Gender,
- Transplant rejection

FullText(HTML)

References(17)

References

[1]	孟莹,张毛毛. 平衡免疫抑制剂在心脏移植中的关键作用[J]. 心血管康复医学杂志,2020,29(5):645-647. doi: 10.3969/j.issn.1008-0074.2020.05.31
[2]	张正刚郑芳. 心脏移植物血管病变研究进展[J]. 器官移植,2020,11(1):104-109. doi: 10.3969/j.issn.1674-7445.2020.01.017
[3]	TENDERIcH G,KOERNER M M,STuETTGEN B,et a1. Pre-existing elevated pulmonary vascular resistance:Long-term hemodynamic follow-up and outcome of recipients after orthotopic heart transplantation[J]. Cardiovasc Surg,2000,41(2):215-219.
[4]	胡盛寿,王春生,董念国. 心脏移植的多中心研究[J]. 中华器官移植杂志,2012,33(5):264-266. doi: 10.3760/cma.j.issn.0254-1785.2012.05.002
[5]	Pei R,Lee J H,Shih N J,et al. Single human leukocyte antigenflow cytometry beads for accurate identification of human leukocyteantigen antibody specificities[J]. Transplantation,2003,75(1):43-49. doi: 10.1097/00007890-200301150-00008
[6]	Stiller C R,Sinclair N R,Abrahams S,et al. Lymphocytedependentantibody and renal graft rejection[J]. Lancet,1971(7913):953-954.
[7]	YUsEN R D,EDwARDs L B,DIPcHAND A I,et a1. Registry of the internatinal society for heart and 1ung transplantation:33rd adult 1ung and heart-1ung transplant report-2016;Focus theme:Primary diagnostic indicatins for transplant[J]. Heart Lung Transplant,2016,35(10):1185-1195. doi: 10.1016/j.healun.2016.08.018
[8]	孙菲菲,房孝生,姜玉杰,等. 57例急性淋巴细胞白血病异基因造血干细胞移植后抗宿主病的发生及影响因素分析[J]. 山东大学学报:医学版,2019,57(7):61-66.
[9]	赵子进,霍治,陈璐瑶. 同种异体心脏移植中急性排斥反应免疫学机制及进展[J]. 现代生物医学进展,2009,9(23):4587-4589.
[10]	TAYLOR D O,EDWARDS L B,BoUCEK M M,et a1. Registry of the international society for heart and lung transplantation:Twenty-third offlcial adult heart transplantation report-2006[J]. Heart Lung Transplant,2006,25(8):869-879. doi: 10.1016/j.healun.2006.05.002
[11]	Avery R K. Cardiac-allograft vasculopathy[J]. N Engl J med,2003,349(9):829-830. doi: 10.1056/NEJMp038124
[12]	Itescu,Silviu,Tung,C M Thomas,Burke E M,et al. An immunological algorithm to predict risk of high-grade rejection in cardiac transplant recipients[J]. Lancet,1998,352(1):263-270.
[13]	姜兆磊. 心脏移植物血管病变的临床研究现状[J]. 国际心血管病杂志,2011,38(1):41-43. doi: 10.3969/j.issn.1673-6583.2011.01.012
[14]	薛梅,梁涛,邱建丽,等. 心脏移植受者生存质量现状的研究[J]. 中华护理杂志,2014,49(8):924-927.
[15]	杨建飞, 魏来, 周亚滨. 心脏移植慢性排斥反应的免疫学研究进展 [J]. 求医问药, 2013, 11（4）: 334-344
[16]	Caro-Oleas J L,González-Escribano M F,González-Roncero F M,et al. Clinical relevance of HLA donor-specific antibodies detectedby single antigen assay in kidney transplantation[J]. Nephrol Dial Transplant,2012,27(3):1231-1238.
[17]	Tait B D,Süsal C,Gebel H M,et al. Consensus guidelines on the testing and clinical management issues associated with HLA and Non-HLA antibodies in transplantation[J]. Transplantation,2013,95(1):19-47. doi: 10.1097/TP.0b013e31827a19cc

Relative Articles(20)

Relative Articles

[1]	Ying ZHAO, Yandan SU, Ruizhu TANG, Yong DUAN, Wenping SHAO. Vitamin D Status of 2563 Subjects in Kunming. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220405
[2]	Gong Chen Yu , Yang Kai Run , Jiang Hua , Wang Zi Qi , Li Lan Jiang , Hu Li Ping , Wu Jian . . Journal of Kunming Medical University,
[3]	Cao Qing , Li Lan , Zou Ying , Li Yun Chuan , Li Yong , Long Jun Jun , Liu Hao Wen , He Liu Yu , Tian Er Miao . . Journal of Kunming Medical University,
[4]	Long Jun Jun , Li Lan . . Journal of Kunming Medical University,
[5]	Zhang Ru Qiang , Ma Yuan Ping , Lv Pin Die , Liu Ping , Wang Fang . Risk Factors of Myocardial Infarction in Chinese Han Population of Yunnan Province. Journal of Kunming Medical University,
[6]	He Li Ping , Yu Jian , Meng Qiong , Chen Ying , Li Xiao Mei . The Influence Factors Analysis of Required Hospitalization among Rural Residents with Different Gender in Zhaotong. Journal of Kunming Medical University,
[7]	Wen Xiao Ling , Luo Jia Hong , Li Xin , Wang Ye Ying , Zhou Yan Mei , Peng Lin Zhen . Analysis of Quality of Life of Elderly People of The Wa Nationality of Different Gender in Rural Areas. Journal of Kunming Medical University,
[8]	Chen Jing Yi . . Journal of Kunming Medical University,
[9]	Liang Yun. . Journal of Kunming Medical University,
[10]	Wang Dong Mei . . Journal of Kunming Medical University,
[11]	Sun Xuan . . Journal of Kunming Medical University,
[12]	Mei Xue . . Journal of Kunming Medical University,
[13]	Zheng Hong Mei . . Journal of Kunming Medical University,
[14]	Wang Fang . . Journal of Kunming Medical University,
[15]	Wang Fang . . Journal of Kunming Medical University,
[16]	Mei Li Jun . . Journal of Kunming Medical University,
[17]	Yang Peng . . Journal of Kunming Medical University,
[18]	Wang Lin . One Case Analysis of Ex-vivo Liver Resection Combined with Partial Liver Autotransplantation for Hepatocellular Carcinoma. Journal of Kunming Medical University,
[19]	Tao Hong Fei . . Journal of Kunming Medical University,
[20]	Yan Ming Liang . . Journal of Kunming Medical University,