Effects of Perindopril on Intestinal Microecology in Obese Rats

Yandong GUO; Rudan HONG; Yanjiao WANG; Teng ZHANG; Yuemei FENG; Nishang ZHANG; Ying QIAN; Zaogai YANG; Fei MI; Jianzhong YIN

doi:10.12259/j.issn.2095-610X.S20221101

Volume 43 Issue 11

Nov. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(11): 9-16

Yandong GUO, Rudan HONG, Yanjiao WANG, Teng ZHANG, Yuemei FENG, Nishang ZHANG, Ying QIAN, Zaogai YANG, Fei MI, Jianzhong YIN. Effects of Perindopril on Intestinal Microecology in Obese Rats[J]. Journal of Kunming Medical University, 2022, 43(11): 9-16. doi: 10.12259/j.issn.2095-610X.S20221101

Citation:

Yandong GUO, Rudan HONG, Yanjiao WANG, Teng ZHANG, Yuemei FENG, Nishang ZHANG, Ying QIAN, Zaogai YANG, Fei MI, Jianzhong YIN. Effects of Perindopril on Intestinal Microecology in Obese Rats[J]. Journal of Kunming Medical University, 2022, 43(11): 9-16. doi: 10.12259/j.issn.2095-610X.S20221101

Citation:

Yandong GUO, Rudan HONG, Yanjiao WANG, Teng ZHANG, Yuemei FENG, Nishang ZHANG, Ying QIAN, Zaogai YANG, Fei MI, Jianzhong YIN. Effects of Perindopril on Intestinal Microecology in Obese Rats[J]. Journal of Kunming Medical University, 2022, 43(11): 9-16. doi: 10.12259/j.issn.2095-610X.S20221101

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Effects of Perindopril on Intestinal Microecology in Obese Rats

doi: 10.12259/j.issn.2095-610X.S20221101

1.
Basic Medical College of Baoshan College of Traditional Chinese Medicine，Baoshan Yunnan 678000
2.
School of Public Health，Kunming Medical University， Kunming Yunnan 650500，China

Received Date: 2022-03-28
Publish Date: 2022-11-25

Abstract

Abstract

Objective To study the effect of perindopril on body weight, blood lipids and intestinal flora of obese rats. Methods SPF Wistar rats were randomly divided into normal group, model group, perindopril low-dose and high-dose groups （0.4, 2 mg/（kg·d））. Changes in LDL-C, HDL-C, UA, GLU and intestinal flora in feces were compared. Results Compared with the normal group, the final body weight, body weight gain and Lee's index of the rats in the model group increased （P < 0.01）, indicating that the model was successfully established; compared with the model group, the body weight of the rats in the perindopril low and high dose groups significantly decreased （ P < 0.05, 0.01）. The results of 16S rRNA sequencing showed that perindopril could improve the level of intestinal flora diversity in rats, and the total number of OTUs in the perindopril low-dose group increased by 4.56%; at the phylum and genus levels, the perindopril low-dose group The species composition of Firmicutes was significantly decreased （P < 0.01）, and the species composition of Alloprevotella, NK4A214_group, no_rank_f__Erysipelotrichaceae, norank_f__Eubacterium_coprostanoligenes_group were significantly increased （P < 0.05, 0.01）, and The species compositions of Actinobacteriota, norank_f__Erysipelotrichaceae, Enterorhabdus and Staphylococcus were significantly increased in the perindopril high-dose group （P < 0.01）. Conclusion Perindopril can reduce the body weight of obese rats, and its effect may be related to the regulation of intestinal flora composition of rats.
- Perindopril,
- Obesity,
- Rats,
- Intestinal microecology

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