Clinical Application of Linaclotide Combined with Compound Polyethylene Glycol Electrolyte in Bowel Preparation in Patients with Chronic Constipation

Zhenguang QI; Xiaoyun LI; Weiwei ZHANG

doi:10.12259/j.issn.2095-610X.S20221116

Volume 43 Issue 11

Nov. 2022

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Zhenguang QI, Xiaoyun LI, Weiwei ZHANG. Clinical Application of Linaclotide Combined with Compound Polyethylene Glycol Electrolyte in Bowel Preparation in Patients with Chronic Constipation[J]. Journal of Kunming Medical University, 2022, 43(11): 130-135. doi: 10.12259/j.issn.2095-610X.S20221116

Citation:

Zhenguang QI, Xiaoyun LI, Weiwei ZHANG. Clinical Application of Linaclotide Combined with Compound Polyethylene Glycol Electrolyte in Bowel Preparation in Patients with Chronic Constipation[J]. Journal of Kunming Medical University, 2022, 43(11): 130-135. doi: 10.12259/j.issn.2095-610X.S20221116

Citation:

Zhenguang QI, Xiaoyun LI, Weiwei ZHANG. Clinical Application of Linaclotide Combined with Compound Polyethylene Glycol Electrolyte in Bowel Preparation in Patients with Chronic Constipation[J]. Journal of Kunming Medical University, 2022, 43(11): 130-135. doi: 10.12259/j.issn.2095-610X.S20221116

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Clinical Application of Linaclotide Combined with Compound Polyethylene Glycol Electrolyte in Bowel Preparation in Patients with Chronic Constipation

doi: 10.12259/j.issn.2095-610X.S20221116

1.
The Second Department of Gastroenterology
2.
Dept. of Education，QingDao Eighth People’s Hospital，Qingdao Shandong 266000
3.
Dept. of Gastroenterology，East Hospital，Qingdao Municipal Hospital，Affiliated to Qingdao University School of Medicine，Qingdao Shandong 266000，China

Received Date: 2022-06-19
Available Online: 2022-10-28
Publish Date: 2022-11-14

Abstract

Abstract

Objective To study the effect and safety of linaclotide combined with compound polyethylene glycol electrolyte （PEG） in bowel preparation in patients with chronic constipation. Methods A total of 174 patients with chronic constipation who underwent colonoscopy in Qingdao Eighth People’s Hospital from March 2021 to February 2022 were selected as the research subjects, and they were divided into group A, group B, and group C by random number table method, with 58 cases in each group. Patients in group A were treated with 3LPEG fractionated bowel cleansing, patients in group B were treated with 3 capsules of linaclotide combined with 3LPEG fractional bowel cleansing, and group C patients were given 4LPEG fractional bowel cleansing. The quality of bowel preparation, colonoscopy time and incidence of adverse reactions were compared among the three groups. Results The scores of the left semicolon, transverse colon, right semicolon and Boston bowel preparation scale （BBPS） total score in groups B and C were higher than those in group A （P < 0.05）. There was no significant difference in the scores of the left semicolon, transverse colon, right semicolon and total BBPS score between group B and group C （P > 0.05）. Among the elderly patients with constipation, the scores of the left semicolon, transverse colon, right semicolon and BBPS total score in group B were higher than those in group C （P < 0.05）. The entry time, exit time and total colonoscopy time of groups B and C were all shorter than those of group A （P < 0.05）. Compared with group C, the entry time, exit time and total colonoscopy time of group B were shorter than those of group C （P < 0.05）. Compared with group C, the incidence of each adverse reaction in groups A and B was lower than that in group C （P < 0.05）. Conclusions Linaclotide combined with fractional oral 3LPEG improves the quality of bowel preparation and shortens the time of colonoscopy compared with single fractional oral 3LPEG. Compared with fractional oral 4LPEG alone, it can achieve the same bowel preparation effect and can reduce the incidence of adverse reactions, with high safety. For elderly patients with chronic constipation, linaclotide combined with fractional oral 3LPEG has a better bowel preparation effect than fractional oral 4LPEG alone.
- Bowel preparation,
- Compound polyethylene glycol electrolyte powder,
- Linaclotide,
- Chronic constipation

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References(23)

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