Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace

Huajun ZHAO; Guoqing PAN; Ying TANG; Zhiyuan WANG; Xiaowei ZHAO; Xiaoyu TUO

doi:10.12259/j.issn.2095-610X.S20221128

Volume 43 Issue 11

Nov. 2022

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2022 > 43(11): 22-29

Yuting ZHENG, Yunshan LIAO, Na FAN, Wenying PAN, Wenjuan ZHENG, Yajuan HAN. Application of Internet Technology in Triage Prevention and Control of Pediatric Infectious Diseases[J]. Journal of Kunming Medical University, 2022, 43(6): 122-126. doi: 10.12259/j.issn.2095-610X.S20220624

Citation:

Huajun ZHAO, Guoqing PAN, Ying TANG, Zhiyuan WANG, Xiaowei ZHAO, Xiaoyu TUO. Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace[J]. Journal of Kunming Medical University, 2022, 43(11): 22-29. doi: 10.12259/j.issn.2095-610X.S20221128

Citation:

PDF( 7320 KB)

Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace

doi: 10.12259/j.issn.2095-610X.S20221128

1.
Mental Health Center Affiliated to Kunming Medical University，Kunming Yunnan 650224
2.
Dept. of Pathology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
3.
Electron Microscopy Lab，School of Basic Medicine，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2022-07-18
Available Online: 2022-10-28
Publish Date: 2022-11-14

Abstract

Abstract

Objective To study the relationship between the expression of receptor tyrosine kinase-like orphan receptor 1 （ROR1） and spread through air space （STAS） in lung adenocarcinoma tissues. Methods We collected 618 cases of lung adenocarcinoma from June 2017 to January 2, 2022, HE staining section was used to determine pathological subtypes and pathological characteristics, count STAS number and grade. The expression of ROR1 was detected by immunohistochemistry staining in different pathological subtypes of lung adenocarcinoma and the relationship with STAS quantity was analyzed. Results ROR1 expressions were higher in micropapillary and solid lung adenocarcinoma （poorly differentiated）（P < 0.001）; ROR1 expression rates were 88.0%, 94.1% in low STAS and high STAS groups, significantly higher than no STAS group （P < 0.001）. Conclusions ROR1 is highly expressed in poorly differentiated lung adenocarcinoma and suggests a higher incidence of STAS. ROR1 is expected to be a new diagnostic biomarker of lung adenocarcinoma for guiding clinical treatment and assisting prognostic judgment, and may be a potential therapeutic target for STAS-positive lung adenocarcinoma.
- Lung adenocarcinoma,
- ROR1,
- Spread through air space,
- Pathological subtypes,
- Immunohistochemistry

FullText(HTML)

References(27)

References

[1]	Sung H,Ferlay J,Siegel R L,et al. Global cancer statistics 2020:GLOBOCAN estimatesof incidence and mortality world wide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2021,71(3):209-249. doi: 10.3322/caac.21660
[2]	Siegel R L,Miller K D,Jemal A. Cancer statistics,2020[J]. CA Cancer J Clin,2020,70(1):7-30. doi: 10.3322/caac.21590
[3]	Travis W D,Brambilla E,Noguchi M,et al. Interna-tional association for the study of lung cancer/American Thoracic Society/European Respiratory Society international multidiscipli-nary classification of lung adenocarcinoma[J]. J Thorac Oncol,2011,6(2):244-285. doi: 10.1097/JTO.0b013e318206a221
[4]	Travis W D,Brambilla E,Nicholson A G,et al. The 2015 World Health Organization classification of lung tumors:impact of genetic,clinical and radiologic advancessince the 2004 classification[J]. J Thorac Oncol,2015,10(9):1243-1260. doi: 10.1097/JTO.0000000000000630
[5]	Vaghjiani R G,Takahashi Y,Eguchi T,et al. Tumor spread through air spaces (STAS)is predictor of occult lymphnodeme-tastasis in clinical stage IA lung adenocarcinoma[J]. J Thorac Oncol,2020,15(5):792-802. doi: 10.1016/j.jtho.2020.01.008
[6]	Masiakowski P,Carroll R D. A novel family of cell surface receptors with tyrosine kinase-like domain[J]. J Biol Chem,1992,267(36):26181-26190. doi: 10.1016/S0021-9258(18)35733-8
[7]	Borcherding N,Kusner D,Liu G H,et al. ROR1,an embryonic protein with an emerg-ing role in cancer biology[J]. Protein Cell,2014,5(7):496-502. doi: 10.1007/s13238-014-0059-7
[8]	Kipps T J. ROR1:An orphan becomes apparent[J]. Blood,2022,140(14):1583-1591. doi: 10.1182/blood.2021014760
[9]	Green J L, Kuntz S G, Sternberg P W. Ror receptor tyrosine kinases: orphans no more[J]. Trends Cell Biol, 2008, 18（11）: 536-544.
[10]	Chiang C L,Goswami S,Frissora F,et al. ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in CLL mouse model[J]. Blood,2019,134(5):432-444. doi: 10.1182/blood.2018882290
[11]	Zhang S,Cui B,Lai H,et al. Ovarian cancer stem cells express ROR1,which can be targeted for anti-cancer-stem-cell therapy[J]. Proc Natl Acad Sci USA,2014,111(48):17266-17271. doi: 10.1073/pnas.1419599111
[12]	Rich B E,Hojjat-Farsangi M,Ghaemimanesh F,et al. Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells[J]. PLoS One,2013,8(4):e61167. doi: 10.1371/journal.pone.0061167
[13]	Zhang S P,Chen L G,Cui B,et al. ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth[J]. PLoS One,2012,7(3):e31127. doi: 10.1371/journal.pone.0031127
[14]	Villalbalj A,Shih A R,Sayo T M S,et al. Accuracy andreproducibility of intraop-erative assessment on tumor spread through air spaces(STAS)in stage l lung adenocarcinomas[J]. J Thorac Oncol,2021,16(4):619-629. doi: 10.1016/j.jtho.2020.12.005
[15]	Kadota K,Nitadori J I,Sima C S,et al. Tumor spread through air spaces is an important pattern of invasion and impacts the frequency and location of recurrences after limited resection for small stage I lung adenocarcinomas[J]. J Thorac Oncol,2015,10(5):806-814.
[16]	Uruga H,Fujii T,Fujimori S,et al. Semiquantitative assessment of tumor spread through air spaces (STAS) in early-stage lung adenocarcinomas[J]. Journal of Thoracic Oncology,2017,12(7):1046-1051. doi: 10.1016/j.jtho.2017.03.019
[17]	Toyokawa G,Yamada Y,Tagawa T,et al. Significance of spread through air spaces in resected pathological stage I lung adenocarcinoma[J]. Ann Thorac Surg,2018,105(6):1655-1663. doi: 10.1016/j.athoracsur.2018.01.037
[18]	Alvarez Moreno J C,Aljamal A A,Bahmad H F,et al. Correlation between spread through air spaces (STAS) and other clinicopathological parameters in lung cancer[J]. Pathol Res Pract,2021,220(4):153376. doi: 10.1016/j.prp.2021.153376.Epub2021Feb16
[19]	王作刚,冯彦,于亮,等. ROR1对人肺癌A549细胞上皮-间质转化的影响[J]. 肿瘤防治研究,2018,45(7):458-462.
[20]	Gentile A,Lazzari L,Benvenuti S,et al. The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells[J]. Int J Cancer,2014,135(10):2305-2316. doi: 10.1002/ijc.28879
[21]	Cui B,Zhang S,Chen L,et al. Targeting RORI inhibits epithelial-mesenchymal transition and metastasis[J]. Cancer Res,2013,73(12):3649-3660. doi: 10.1158/0008-5472.CAN-12-3832
[22]	马文琦,何鑫,张红丽,等. 下调结直肠癌细胞受体酪氨酸激酶样孤儿受体抑制细胞生长并促进其凋亡[J]. 细胞与分子免疫学杂志,2016,32(5):655-659,665. doi: 10.13423/j.cnki.cjcmi.007760
[23]	Tomoya,Yamaguchi,Can Lu,et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1[J]. Nature Communications,2016,7(4):10060. doi: 10.1038/ncomms10060
[24]	Zheng Y Z,Ma R,Zhou J,et al. ROR1 is a novel prognostic biomarker in patients with lung adenocarcinoma[J]. Scientific Reports,2016,6(10):36447.
[25]	Onozato Y,Nakajima T,Yokota H,et al. Radiomics is feasible for prediction of spread through air spaces in patients with nonsmall cell lung cancer[J]. Scientific Reports,2021,11(1):13526. doi: 10.1038/s41598-021-93002-4
[26]	Han Y B,Kim H,Mino-Kenudson M,et al. Tumor spread through air spaces (STAS):prognostic significance of grading in non-small cell lung cancer[J]. Mod Pathol,2021,34(3):549-561. doi: 10.1038/s41379-020-00709-2
[27]	Chae M,Jeon J H,Chung J H,et al. Prognostic significance of tumor spread through air spaces in patients with stage IA part-solid lung adenocarcinoma after sublobar resection[J]. Lung Cancer,2021,152(2):21-26.

Relative Articles(20)

Relative Articles

[1]	Haijun LOU, Zhenyu ZHANG, Sureyan ALIMUJIANG, Menggen MENG, Hang CHEN, Muli WUDU. Expression Characteristics and Clinical Pathological Features of TMEM33 in Lung Adenocarcinoma. Journal of Kunming Medical University, 2025, 46(3): 19-26. doi: 10.12259/j.issn.2095-610X.S20250304
[2]	Hongxiu YANG, Zhongshan ZHU. Effect of HPRT1 Gene Expression on Overall Survival of Patients with Lung Adenocarcinoma. Journal of Kunming Medical University, 2024, 45(8): 17-23. doi: 10.12259/j.issn.2095-610X.S20240803
[3]	Wangxun SHEN, Yinyu YANG, Canwei LI, Jinrong YANG, Sijing WU, Huajun ZHAO, Xiaoyu TUO. Expression and Clinical Significance of ROR1 in Different Histologic Types of Invasive Lung Adenocarcinoma. Journal of Kunming Medical University, 2024, 45(5): 60-65. doi: 10.12259/j.issn.2095-610X.S20240509
[4]	Bangqing LIU, Jianfeng LI, Xiaohui LIU, Jinnan ZHANG, Jinping LIANG. MiR-196b Promotes Proliferation and Migration of Lung Adenocarcinoma by Targeting ERG. Journal of Kunming Medical University, 2023, 44(10): 83-91. doi: 10.12259/j.issn.2095-610X.S20231023
[5]	Maofang WU, Yongchun ZHOU, Jingjing CAI, Xin MO, Yinwei LI, Jiahui MAO. EGFR Gene Mutation State and Its Clinical Significance in Multi-nodular Lung Adenocarcinoma in Yunnan Province. Journal of Kunming Medical University, 2022, 43(2): 60-66. doi: 10.12259/j.issn.2095-610X.S20220215
[6]	Xilan WU, Hong SHEN, Susheng SHI, Zhihui ZHANG, Lei GUO, Fang WANG. The Expression of PD-L1, BRAF^V600E, CD68 Protein and the Significance of Tumor Infiltrating Lymphocytes in the Diagnosis of Malignant Melanoma. Journal of Kunming Medical University, 2022, 43(9): 13-18. doi: 10.12259/j.issn.2095-610X.S20220923
[7]	Hong SHEN, Hairong HUA, Liping GAO, Yixiao HE, Xuezhi YANG, Xiangfei ZENG, Fang WANG, Jingling SONG. Expressions and Clinical Significance of LEA and CDw75 in Colorectal Adenocarcinoma. Journal of Kunming Medical University, 2022, 43(7): 9-17. doi: 10.12259/j.issn.2095-610X.S20220717
[8]	Zhongshan ZHU, Zhou YANG, Chengchuan JIANG, Xiaobing LI, Dou REN, Cheng HUANG, Weiwei ZHANG, Xiangjun LI, Shunli ZHAO. An Analysis of PLA2G1B Expression and Prognosis in Patients with Lung Adenocarcinoma. Journal of Kunming Medical University, 2022, 43(9): 70-76. doi: 10.12259/j.issn.2095-610X.S20220912
[9]	Wu Qi Yan , Bian Ge Yuan , Cheng Hui Jun, Li Jiao Xia , Wang Shu Ting , Huang Zhao Lue . . Journal of Kunming Medical University, 2020, 41(09): 32-37.
[10]	Zhu Zhong Shan , Yan Wen Hui , Li Xiao Bing , Yang Zhou , Bai Peng . Driver Genes Mutation and Survival Analysis in 200 Patients with Pulmonary Adenocarcinoma Brain Metastasis. Journal of Kunming Medical University, 2018, 39(08): 47-50.
[11]	Xu Jian Xin . . Journal of Kunming Medical University,
[12]	Zhao Yun Hong . . Journal of Kunming Medical University,
[13]	Li Yun Fen . . Journal of Kunming Medical University,
[14]	Zhou Shu . . Journal of Kunming Medical University,
[15]	Yu Jie . . Journal of Kunming Medical University,
[16]	. Effects of Cyclosporine A on RAF-1 Expression in Skeletal Muscles of Hindlimbs in Adult Rats after Spinal Cord Transaction. Journal of Kunming Medical University,
[17]	Li Xiao Ming . . Journal of Kunming Medical University,
[18]	Su Xing . . Journal of Kunming Medical University,
[19]	. . Journal of Kunming Medical University,
[20]	Wang Xiao Li . . Journal of Kunming Medical University,

Supplements(0)

Cited By

Cited by

Periodical cited type(2)

1.	宋楠，吕娟，王春立，刘文，迟巍，刘洋，邓卓，孙宏国. 智能化导诊信息系统在儿童专科医院的构建及应用. 中国护理管理. 2024(09): 1394-1398 .
2.	李喜明. 计划免疫健康教育在儿童传染病预防控制中的应用效果. 中国民康医学. 2023(04): 170-173 .