Study on Serum Markers of Intestinal Barrier Damage in Heroin Addicts at Different Withdrawal Times

Yuansen LI; Cheng CHEN; Yan TIAN; Ruo SHU; Yu XU; Yuanhua LI

doi:10.12259/j.issn.2095-610X.S20230709

Volume 44 Issue 7

Jul. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(7): 94-99

Yuansen LI, Cheng CHEN, Yan TIAN, Ruo SHU, Yu XU, Yuanhua LI. Study on Serum Markers of Intestinal Barrier Damage in Heroin Addicts at Different Withdrawal Times[J]. Journal of Kunming Medical University, 2023, 44(7): 94-99. doi: 10.12259/j.issn.2095-610X.S20230709

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Yuansen LI, Cheng CHEN, Yan TIAN, Ruo SHU, Yu XU, Yuanhua LI. Study on Serum Markers of Intestinal Barrier Damage in Heroin Addicts at Different Withdrawal Times[J]. Journal of Kunming Medical University, 2023, 44(7): 94-99. doi: 10.12259/j.issn.2095-610X.S20230709

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Study on Serum Markers of Intestinal Barrier Damage in Heroin Addicts at Different Withdrawal Times

doi: 10.12259/j.issn.2095-610X.S20230709

1.
Dept. of Gastrointestinal and Hernia Surgery
2.
Dept. of Anesthesiology，The 1st Affiliated of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2023-04-27
Available Online: 2023-07-18
Publish Date: 2023-07-25

Abstract

Abstract

Objective To investigate the mechanisms of intestinal barrier damage after heroin withdrawal by analyzing changes in markers of intestinal barrier damage at different withdrawal times, providing a new direction for the relationship between altered psychiatric symptoms and the intestinal barrier after heroin withdrawal. Methods 14 1-week heroin withdrawal subjects （HWS1W）, 24 3-months heroin withdrawal subjects （HWS3M） and 26 healthy controls （HCs） were recruited, and serum iFABP, D-LDH, iFABP, DAO, LBP, Zonulin, BDNF and D-LDH were determined by ELISA. Results Serum D-LDH, DAO, LBP, Zonulin and BDNF levels in HWS1W group were significantly higher than those in HCs （P < 0.001）. Serum iFABP, D-LDH, DAO, and BDNF in HWS3M group were significantly higher than those in HCs group （P < 0.001）. DAO increased significantly at 1 week of heroin withdrawal and decreased significantly at 3 months, but was still higher than the healthy control group （P < 0.001）. iFABP showed no change in the acute withdrawal period （1 week）, but increased at about 3 months of withdrawal. LBP and Zonulin increased significantly in the heroin abstention group for about one week, but there was no significant difference between the HWS3M group and the HCs group （P > 0.05）. The levels of D-LDH and BDNF were significantly increased in HWS1W and HWS3M groups （P < 0.001）. Conclusions The present study showed that intestinal barrier dysfunction occurred both 1 week and 3 months after heroin withdrawal. After 1 week of abstinence, intestinal barrier damage may be associated with intestinal flora disorder, changes in tight junction proteins, intestinal inflammation and intestinal epithelial integrity damage. After 3 months of abstinence, intestinal barrier damage is more likely to result from persistent damage to the intestinal barrier epithelium.
- Heroin,
- Intestinal barrier,
- iFABP,
- D-LDH,
- DAO,
- LBP,
- Zonulin,
- BDNF

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References(30)

References

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