Correlation of <i>ERAP</i> Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine

Yuhan SHI; Jing LI; Shuyuan LIU; Ting ZHAO; Jingsi YANG; Li SHI; Jiangli LIANG

doi:10.12259/j.issn.2095-610X.S20230711

Volume 44 Issue 7

Jul. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2023 > 44(7): 22-28

Yuhan SHI, Jing LI, Shuyuan LIU, Ting ZHAO, Jingsi YANG, Li SHI, Jiangli LIANG. Correlation of ERAP Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine[J]. Journal of Kunming Medical University, 2023, 44(7): 22-28. doi: 10.12259/j.issn.2095-610X.S20230711

Citation:

Yuhan SHI, Jing LI, Shuyuan LIU, Ting ZHAO, Jingsi YANG, Li SHI, Jiangli LIANG. Correlation of ERAP Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine[J]. Journal of Kunming Medical University, 2023, 44(7): 22-28. doi: 10.12259/j.issn.2095-610X.S20230711

Citation:

PDF( 619 KB)

Correlation of ERAP Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine

doi: 10.12259/j.issn.2095-610X.S20230711

1.
Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118
2.
College of Agronomy and Biotechnology，Yunnan Agricultural University，Kunming Yunnan 650201，China

Received Date: 2023-06-11
Available Online: 2023-07-17
Publish Date: 2023-07-25

Abstract

Abstract

Objective To analyze the relationship between endoplasmic reticulum aminopeptidases （ERAP） gene polymorphisms and serum polio antibodies induced by sequential polio vaccine immunization. Methods A total of 243 Zhuang individuals were selected from the Guangxi Zhuang Autonomous Region who received two doses of inactivated polio vaccine and one dose of bivalent oral polio vaccine. Polio-neutralizing antibodies types I, II and III were tested from pre-immunization and 28 days after immunizations, and six ERAP1 and two ERAP2 SNPs were genotyped using TaqMan probe genotyping. The allele frequency and genotype frequency were calculated for each SNP, and the association between the SNPs and the polio antibody response was analyzed. Results It was found that individuals carrying the rs2549782-G andrs2248374-A allele of the ERAP1 gene had lower levels of type I polio-neutralizing antibodies compared to those carrying the T and G alleles, respectively （both of 11.590±1.979 vs 11.950±1.895, Padj = 0.031）. In addition, it was observed that GT and AG genotypes of rs2549782 of rs2248374 exhibited lower GMT type I polio-neutralizing antibodies than those of TT and GG genotypes （both of 11.741±0.141 vs 12.378±0.157, Padj = 0.045）. Conclusion Polio vaccine-induced antibody responses may be associated with ERAP2 gene polymorphism.

FullText(HTML)

References(31)

References

[1]	Tan P L,Jacobson R M,Poland G A,et al. Twin studies of immunogenicity-determining the genetic contribution to vaccine failure[J]. Vaccine,2001,19(17-19):2434-2439. doi: 10.1016/S0264-410X(00)00468-0
[2]	Newport M J,Goetghebuer T,Weiss H A,et al. Genetic regulation of immune responses to vaccines in early life[J]. Genes Immun,2004,5(2):122-129. doi: 10.1038/sj.gene.6364051
[3]	Neefjes J,Jongsma M L,Paul P,et al. Towards a systems understanding of MHC class I and MHC class II antigen presentation[J]. Nat Rev Immunol,2011,11(12):823-836. doi: 10.1038/nri3084
[4]	Vyas J M,Van Der Veen A G,Ploegh H L. The known unknowns of antigen processing and presentation[J]. Nat Rev Immunol,2008,8(8):607-618. doi: 10.1038/nri2368
[5]	Yao Y,Liu N,Zhou Z,et al. Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations[J]. Hum Immunol,2019,80(5):325-334. doi: 10.1016/j.humimm.2019.02.011
[6]	Hattori A,Tsujimoto M. Endoplasmic reticulum aminopeptidases:Biochemistry,physiology and pathology[J]. J Biochem,2013,154(3):219-228. doi: 10.1093/jb/mvt066
[7]	Nguyen T T,Chang S C,Evnouchidou I,et al. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1[J]. Nat Struct Mol Biol,2011,18(5):604-613. doi: 10.1038/nsmb.2021
[8]	Evnouchidou I,Birtley J,Seregin S,et al. A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing[J]. J Immunol,2012,189(5):2383-2392. doi: 10.4049/jimmunol.1200918
[9]	傅宇婷,黄腾,英志芳,等. 脊髓灰质炎免疫策略调整进程中不同免疫程序接种效果的比较[J]. 中国生物制品学杂志,2019,32(7):786-793. doi: 10.13200/j.cnki.cjb.002680
[10]	赵志梅,傅宇婷,施红媛,等. Sabin株脊髓灰质炎灭活疫苗与不同剂型Ⅰ型Ⅲ型脊髓灰质炎减毒活疫苗序贯接种的抗体滴度比较[J]. 中华疾病控制杂志,2019,23(4):402-406. doi: 10.16462/j.cnki.zhjbkz.2019.04.007
[11]	Liao G,Li R,Li C,et al. Phase 3 Trial of a sabin strain-based inactivated poliovirus vaccine[J]. J Infect Dis,2016,214(11):1728-1734. doi: 10.1093/infdis/jiw433
[12]	Liao G,Li R,Li C,et al. Safety and immunogenicity of inactivated poliovirus vaccine made from sabin strains:A phase II,randomized,positive-controlled trial[J]. J Infect Dis,2012,205(2):237-243. doi: 10.1093/infdis/jir723
[13]	Chen H,Li L,Weimershaus M,et al. ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing[J]. Sci Rep,2016,6(1):28902. doi: 10.1038/srep28902
[14]	Stratikos E,Stamogiannos A,Zervoudi E,et al. A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition[J]. Front Oncol,2014,4(4):363.
[15]	Alvarez-Navarro C,López DE Castro J A. ERAP1 structure,function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases[J]. Mol Immunol,2014,57(1):12-21.
[16]	Stamogiannos A,Koumantou D,Papakyriakou A,et al. Effects of polymorphic variation on the mechanism of endoplasmic reticulum aminopeptidase 1[J]. Mol Immunol,2015,67(2 Pt B):426-435.
[17]	Coulombe-Huntington J,Lam K C,Dias C,et al. Fine-scale variation and genetic determinants of alternative splicing across individuals[J]. PLoS Genet,2009,5(12):e1000766. doi: 10.1371/journal.pgen.1000766
[18]	Cagliani R,Riva S,Biasin M,et al. Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection[J]. Hum Mol Genet,2010,19(23):4705-4714. doi: 10.1093/hmg/ddq401
[19]	Biasin M,Sironi M,Saulle I,et al. Endoplasmic reticulum aminopeptidase 2 haplotypes play a role in modulating susceptibility to HIV infection[J]. AIDS,2013,27(11):1697-1706. doi: 10.1097/QAD.0b013e3283601cee
[20]	Liu S,Cao D,Shen Y,et al. The ERAP gene is associated with HCV chronic infection in a Chinese Han population[J]. Hum Immunol,2017,78(11-12):731-738. doi: 10.1016/j.humimm.2017.10.005
[21]	Kuiper J J W,Setten J V,Devall M,et al. Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) uveitis[J]. Hum Mol Genet,2018,27(24):4333-4343.
[22]	Vanhille D L,Hill L D,Hilliard D D,et al. A novel ERAP2 haplotype structure in a chilean population: Implications for ERAP2 protein expression and preeclampsia risk[J]. Mol Genet Genomic Med,2013,1(2):98-107. doi: 10.1002/mgg3.13
[23]	Castro-Santos P,Moro-García M A,Marcos-Fernández R,et al. ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population[J]. Innate Immun,2017,23(5):476-481. doi: 10.1177/1753425917716527
[24]	Jiang R,Liu X,Sun X,et al. Immunogenicity and safety of the inactivated poliomyelitis vaccine made from sabin strains in a phase IV clinical trial for the vaccination of a large population[J]. Vaccine,2021,39(9):1463-1471. doi: 10.1016/j.vaccine.2021.01.027
[25]	He H,Wang Y,Deng X,et al. Immunogenicity of three sequential schedules with sabin inactivated poliovirus vaccine and bivalent oral poliovirus vaccine in Zhejiang,China: an open-label,randomised,controlled trial[J]. Lancet Infect Dis,2020,20(9):1071-1079. doi: 10.1016/S1473-3099(19)30738-8
[26]	Jacobson R M,Poland G A,Vierkant R A,et al. The association of class I HLA alleles and antibody levels after a single dose of measles vaccine[J]. Hum Immunol,2003,64(1):103-109. doi: 10.1016/S0198-8859(02)00741-3
[27]	Ovsyannikova I G,Jacobson R M,Vierkant R A,et al. Replication of rubella vaccine population genetic studies:Validation of HLA genotype and humoral response associations[J]. Vaccine,2009,27(49):6926-6931. doi: 10.1016/j.vaccine.2009.08.109
[28]	Mineta M,Tanimura M,Tana T,et al. Contribution of HLA class I and class II alleles to the regulation of antibody production to hepatitis B surface antigen in humans[J]. Int Immunol,1996,8(4):525-531. doi: 10.1093/intimm/8.4.525
[29]	Hayney M S,Poland G A,Dimanlig P,et al. Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus[J]. Vaccine,1997,15(1):3-6. doi: 10.1016/S0264-410X(96)00133-8
[30]	Yucesoy B,Talzhanov Y,Johnson V J,et al. Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations[J]. Vaccine,2013,31(46):5381-5391. doi: 10.1016/j.vaccine.2013.09.026
[31]	Lankat-Buttgereit B,Tampe R. The transporter associated with antigen processing:Function and implications in human diseases[J]. Physiol Rev,2002,82(1):187-204. doi: 10.1152/physrev.00025.2001

Relative Articles(20)

Relative Articles

[1]	Zhixin NIU, Lihua TANG, Lei SHI, Chao HONG, Yufeng YAO, Zhiling YAN. Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population. Journal of Kunming Medical University, 2024, 45(5): 8-15. doi: 10.12259/j.issn.2095-610X.S20240502
[2]	Xueya CHEN, Jinmei XU, Zhi LI, Yan LIANG, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia. Journal of Kunming Medical University, 2024, 45(11): 16-21. doi: 10.12259/j.issn.2095-610X.S20241103
[3]	Chao HONG, Xudong XIANG, Yingfu LI, Yang CAO, Xueya CHEN, Shuai LI, Anhao XING, Mu LIN, Qianli MA. Association of Polymorphisms in the 3' UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer. Journal of Kunming Medical University, 2024, 45(3): 7-17. doi: 10.12259/j.issn.2095-610X.S20240302
[4]	Ni GUO, Cheng ZHANG, Chao HONG, Weipeng LIU, Yufeng YAO, Zhiling YAN. Correlation of KRAS Gene 3′ UTR Polymorphisms with Cervical Cancer and Cervical Intraepithelial Neoplasia in Chinese Han Population in Yunnan Province. Journal of Kunming Medical University, 2024, 45(2): 14-22. doi: 10.12259/j.issn.2095-610X.S20240203
[5]	Yuhan SHI, Jianghong CHAI, Jinmei XU, Mu LIN, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association between miR-146a Gene Polymorphism and Cervical Intraepithelial Neoplasia. Journal of Kunming Medical University, 2024, 46(): 1-7.
[6]	Runan QI, Lei SHI, Shuyuan LIU, Jing LI, Li SHI. Correlation Analysis of HLA-DM Gene Polymorphisms with Polio Vaccine-induced Antibody Response. Journal of Kunming Medical University, 2024, 45(1): 8-14. doi: 10.12259/j.issn.2095-610X.S20240102
[7]	Tiantian CHENG, Wensa YIN, Jia WANG, Yumei LU, Xuanyu CHEN, Shengjie NIE, Linlin LIU. Association between TMTC1 Gene Polymorphisms and Schizophrenia. Journal of Kunming Medical University, 2023, 44(10): 161-167. doi: 10.12259/j.issn.2095-610X.S20231014
[8]	Rongshuang WU, Jiangli PENG, Yonggang CHEN, Jie CHEN, Guowei MA, Xianrui LI, Xie LI, Chunhong YU. Associations between SLC2A9 Single Nucleotide Polymorphisms and Susceptibility to Pyrazinamide Induced Hyperuricemia. Journal of Kunming Medical University, 2023, 44(4): 40-47. doi: 10.12259/j.issn.2095-610X.S20230409
[9]	Shujin LI, Yanfei YANG, Min SU, Yu LING, Yanqiong RAO, Jihua CUI. Single Nucleotide Polymorphisms in Children with Attention Deficit Hyperactivity Disorder Comorbid Emotion Problems. Journal of Kunming Medical University, 2023, 44(4): 139-147. doi: 10.12259/j.issn.2095-610X.S20230420
[10]	Cong MEI, Xiao-chun WENG, Bao-kun PENG, Sui-jun YAN, Chun LI, Qiong ZHOU, Zhe TANG. Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality. Journal of Kunming Medical University, 2021, 42(3): 135-139. doi: 10.12259/j.issn.2095-610X.S20210332
[11]	Dong-yun LI, Shun-kui GANG, Jie LI, Ming-xing ZHANG, Lei LI. Association of ABCG2，SLC2A9，SLC17A3 and PRKG2 SNPs Variants with Gout in the Hani Population in China. Journal of Kunming Medical University, 2021, 42(3): 54-60. doi: 10.12259/j.issn.2095-610X.S20210320
[12]	Xiao-hui RUAN, Qian XIANG, Yu-ming WANG, Zhi-han ZHOU, Xian ZHANG, Yan GUO, Xiao-rui YANG. The Correlation between Vitamin D Receptor Gene Bg1I and Cdx-2 Polymorphism and Hashimoto’ s Thyroiditis. Journal of Kunming Medical University, 2021, 42(8): 132-139. doi: 10.12259/j.issn.2095-610X.S20210824
[13]	Xiang Xi , Wang Yu Ming , Yang Yan Run , Li Wan Bi , Zhang Xian , Yang Cai , Liu Hua . The Relationship between Vitamin D Receptor (VDR) Gene ApaI, FokI, TaqI, Tru9I Single Nucleotide Polymorphism and Hashimoto's Thyroiditis. Journal of Kunming Medical University, 2018, 39(04): 88-94.
[14]	Xiang Xi , Li Wan Bi , Zhang Xian , Liu Hua , Wang Yu Ming , Yang Cai , Bai Yun Xia . Correlation between Vitamin D Receptor (VDR) Gene ApaⅠ, BsmⅠ Single Nucleotide Polymorphism and Diabetic Kidney Disease in Type 2 Diabetic Patients. Journal of Kunming Medical University, 2017, 38(08): 79-85.
[15]	Liu Cheng Xiu . Association Study of TNF-α and ALCAM Polymorphisms with Chronic HCV Infection in Yunnan Han Population. Journal of Kunming Medical University,
[16]	Xiang Xi . The Correlation between Vitamin D Receptor Gene FokI Single Nucleotide Polymorphism and Diabetic Kidney Disease. Journal of Kunming Medical University,
[17]	Dai Shu Ying . . Journal of Kunming Medical University,
[18]	Li Ying . . Journal of Kunming Medical University,
[19]	Liu Li Li . . Journal of Kunming Medical University,
[20]	Yang Xiao Lei . . Journal of Kunming Medical University,