Investigation on Occupational Exposure and Protection of Cytotoxic Drugs among PIVAS Personnel in Yunnan Province

Hongyin ZHANG; Hongmei ZHU; Huiqin ZHANG; Hongwen YAO; Guirong ZHU; Lin LI

doi:10.12259/j.issn.2095-610X.S20230722

Volume 44 Issue 7

Jul. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(7): 105-112

Hongyin ZHANG, Hongmei ZHU, Huiqin ZHANG, Hongwen YAO, Guirong ZHU, Lin LI. Investigation on Occupational Exposure and Protection of Cytotoxic Drugs among PIVAS Personnel in Yunnan Province[J]. Journal of Kunming Medical University, 2023, 44(7): 105-112. doi: 10.12259/j.issn.2095-610X.S20230722

Citation:

Hongyin ZHANG, Hongmei ZHU, Huiqin ZHANG, Hongwen YAO, Guirong ZHU, Lin LI. Investigation on Occupational Exposure and Protection of Cytotoxic Drugs among PIVAS Personnel in Yunnan Province[J]. Journal of Kunming Medical University, 2023, 44(7): 105-112. doi: 10.12259/j.issn.2095-610X.S20230722

Citation:

Hongyin ZHANG, Hongmei ZHU, Huiqin ZHANG, Hongwen YAO, Guirong ZHU, Lin LI. Investigation on Occupational Exposure and Protection of Cytotoxic Drugs among PIVAS Personnel in Yunnan Province[J]. Journal of Kunming Medical University, 2023, 44(7): 105-112. doi: 10.12259/j.issn.2095-610X.S20230722

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Investigation on Occupational Exposure and Protection of Cytotoxic Drugs among PIVAS Personnel in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20230722

1.
Dept. of Pharmacy，Yunnan Cancer Hospital，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan，650118
2.
Dept. of Pharmacy，The 2nd Affiliated Hospital of Yunnan University of Chinese Medicine，Kunming Yunnan 650041
3.
Key Laboratory of Natural Drug Pharmacology，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-05-08
Available Online: 2023-07-17
Publish Date: 2023-07-25

Abstract

Abstract

Objective To understand the occupational exposure situation of staff in the pharmacy intravenous admixture services （PIVAS） of Yunnan Province and identify the issues related to occupational protection in PIVAS staff. Methods Based on the “Quality Management Specification for Intravenous Dispensing of Cytotoxic Drugs in Medical Institutions” issued by the Chinese Pharmaceutical Association, a questionnaire survey was designed and tested using the Delphi method and reliability and validity analysis. The survey was conducted through “Wenjuanxing” in December 2021 among PIVAS staff in Yunnan Province hospitals. Results A total of 393 questionnaires were distributed and collected. After excluding invalid questionnaires based on inclusion and exclusion criteria, 382 valid questionnaires were obtained, with an effective response rate of 97.2%. The survey results showed that PIVAS staff in tertiary hospitals had more exposure to cytotoxic drugs and higher occupational exposure risks compared to staff in secondary hospitals. The hazards of cytotoxic drugs significantly increased with exposure time. There were issues with inadequate awareness of cytotoxic drug protection, improper handling of accidental exposure, and incomplete protection systems. Conclusions Occupational exposure is an important threat to the health of healthcare workers. It is necessary to establish and improve occupational protection management systems, enhance the awareness of occupational protection among healthcare workers, and implement effective occupational protection measures in order to reduce the hazards of occupational exposure.
- PIVAS,
- Chemotherapy drugs,
- Occupational exposure,
- Occupational protection

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References(20)

References

[1]	Mahmoodi M,Soleyman-Jahi S,Zendehdel K,et al. Chromosomal aberrations,sister chromatid exchanges,and micronuclei in lymphocytes of oncology department personnel handling anti-neoplastic drugs[J]. Drug Chem Toxicol,2017,40(2):235-240. doi: 10.1080/01480545.2016.1209678
[2]	Myers C E. History of sterile compounding in U. S. hospitals: : learning from the tragic lessons of the past[J]. Am J Health Syst Pharm,2013,70(16):1414-1427. doi: 10.2146/ajhp130112
[3]	王宁,刘硕,杨雷,等. 2018全球癌症统计报告解读[J]. 肿瘤综合治疗电子杂志,2019,5(1):87-97.
[4]	Ramazani M,Jaktaji R P,Shirazi F H,et al. Analysis of apoptosis related genes in nurses exposed toantineoplastic drugs[J]. BMC Pharmacol Toxicol,2019,20(1):74. doi: 10.1186/s40360-019-0372-0
[5]	Turci R,Minoia C,Sottani C,et al. Occupational exposure to antineoplastic drugs in seven Italianhospitals: The effect of quality assurance and adherence to guidelines[J]. Journal of Oncology Pharmacy Practice,2011,17(4):320-332.
[6]	Forges F,Blanc E,Raymond B,et al. Evaluation of a safeinfusion device on reducing occupational exposure of nurses toantineoplastic drugs: A comparative prospective studyContamoins-1[J]. Int Arch Occup Environ Health,2021,94(6):1317-1325. doi: 10.1007/s00420-021-01679-x
[7]	张艳艳. 静脉用药调配中心调配化疗药物人员职业暴露与防护现状调查[D]. 滨州: 滨州医学院, 2020.
[8]	中国药学会医院药学专业委员会. 医疗机构静脉用细胞毒性药物调配质量管理工作规范[J]. 中国药学杂志,2020,55(1):77-80. doi: 10.11669/cpj.2020.01.016
[9]	梁昌昊, 尹冠翔, 王雅琪, 等. 中医药临床实践指南制订和修订中德尔菲法应用的方法流程及建议[J]. 协和医学杂志, 2023, 14（5）: doi: 10.12290/xhyxzz.2022-0649.
[10]	李慧珍,宗星煜,王晶亚,等. 基于改良德尔菲法与优序图法的中医药团体标准评价指标体系构建[J]. 中国中医基础医学杂志,2023,29(5):775-780.
[11]	孙世光,王婧婧,李自发,等. 旷场实验: 昆明小鼠行为学评价方法的重测信度检验[J]. 中华行为医学与眼科学,2010,19(12):1093-1095.
[12]	王莉,张淑敏,王昱杰,等. 城市中学生压力源评价量表编制及信效度研究[J]. 中国学校卫生,2023,44(6):875-879.
[13]	余超,李文学,李迎月,等. 省级食品安全监督抽检工作样本量的确定方法研究[J]. 食品安全质量检测学报,2019,10(12):3869-3872.
[14]	侯洁,郝志英,段金菊. 不同医院不同环境表面化疗药物污染情况调查[J]. 药物流行病学杂志,2018,15(10):145-146.
[15]	Izzo V,Charlier B,Bloise E,et al. A UHPLC-MS/MS-basedmethod for the simultaneous monitoring of eight antiblastic drugs inplasma and urine of exposed healthcare workers[J]. J Pharm Biomed Anal,2018,154:245-251. doi: 10.1016/j.jpba.2018.03.024
[16]	赫杰. 肿瘤学概论[M]. 第2版. 北京: 人民卫生出版社, 2018: 151-159.
[17]	沙永生. 静脉化疗药物配置中心护士的自我防护及管理[J]. 天津护理,2009(4):233-234.
[18]	叶珠赛,陈秀英,游永月. 我院静脉药物配置中心护理人员职业危害情况及防护措施[J]. 福建医药杂志,2020,42(3):167-168.
[19]	李海风,高书萍,霍红娟,等. 静脉药物配置中心对细胞毒药物职业防护的调查[J]. 河北医药,2014,36(10):1587-1588.
[20]	关富敏,蒙世文,贾云灿. 静脉用药调配中心在配置细胞毒性药物过程中的职业防护管理[J]. 中国卫生产业,2020,8(22):22-24.

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