Pharmacokinetic Study of Dexmedetomidine in Patients with Different Degrees of Burn

Ling ZHAO; Shulan JIAO; Yongyu SI; Liu YANG; Yinghui BU

doi:10.12259/j.issn.2095-610X.S20230725

Volume 44 Issue 7

Jul. 2023

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Ling ZHAO, Shulan JIAO, Yongyu SI, Liu YANG, Yinghui BU. Pharmacokinetic Study of Dexmedetomidine in Patients with Different Degrees of Burn[J]. Journal of Kunming Medical University, 2023, 44(7): 100-104. doi: 10.12259/j.issn.2095-610X.S20230725

Citation:

Ling ZHAO, Shulan JIAO, Yongyu SI, Liu YANG, Yinghui BU. Pharmacokinetic Study of Dexmedetomidine in Patients with Different Degrees of Burn[J]. Journal of Kunming Medical University, 2023, 44(7): 100-104. doi: 10.12259/j.issn.2095-610X.S20230725

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Pharmacokinetic Study of Dexmedetomidine in Patients with Different Degrees of Burn

doi: 10.12259/j.issn.2095-610X.S20230725

1.
Dept. of Anesthesiology
2.
Dept. of Pharmacy，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2023-05-08
Available Online: 2023-07-10
Publish Date: 2023-07-25

Abstract

Abstract

Objective To investigate the pharmacokinetics of dexmedetomidine in burn patients with different degrees in order to improve the quality of anesthesia in burn patients. Methods Forty-five burn patients undergoing elective surgery were selected in this study. Among them, patients undergoing scar excision and skin grafting were included in group A, and patients with moderate and severe burns were respectively included in group B and group C, with 15 cases in each group. Patients in the three groups were respectively pumped dexmedetomidine 1µg/kg intravenously at a constant rate 10min before anesthesia induction. Before dexmedetomidine administration, during the administration of 1 （TCI1）, 3 （TCI3）, 5 （TCI5） and 10 （TCI10）min, after discontinuation of 2 （T2）, 5 （T5）, 10 （T10）, 15 （T15）, 20 （T20）, 25 （T25）, 30 （T30）, 45 （T45）, 60 （T60）, 90 （T90）, 120 （T120） min, we collected the arterial blood, and determined the plasma drug concentration （Cm） of dexmedetomidine. At last, we calculated the pharmacokinetic parameters. Results The Vd CL, K12, and K10 in group C were all higher than those in group A, the Vd, CL in group C were higher than those in group B, and the Vd in group B was higher than that in group A. Conclusions In severe burn patients, the Vd, CL, K12, and K10 of dexmedetomidine are increased, and Cm is decreased. The dose of dexmedetomidine can be appropriately increased to improve the quality of anesthesia and reduce complications.
- Burn,
- Dexmedetomidine,
- Pharmacokinetic

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References(17)

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