Evaluation of Cardiac Toxicity of Anthracyclines in Children with Acute Leukemia Based on Tei Index

Xuemei CHEN; Pin GUO; Liufang CHUAN; Zi WANG; Xuejiao LI; Wenji HE

doi:10.12259/j.issn.2095-610X.S20240216

Volume 45 Issue 2

Feb. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(2): 117-122

Xuemei CHEN, Pin GUO, Liufang CHUAN, Zi WANG, Xuejiao LI, Wenji HE. Evaluation of Cardiac Toxicity of Anthracyclines in Children with Acute Leukemia Based on Tei Index[J]. Journal of Kunming Medical University, 2024, 45(2): 117-122. doi: 10.12259/j.issn.2095-610X.S20240216

Citation:

Xuemei CHEN, Pin GUO, Liufang CHUAN, Zi WANG, Xuejiao LI, Wenji HE. Evaluation of Cardiac Toxicity of Anthracyclines in Children with Acute Leukemia Based on Tei Index[J]. Journal of Kunming Medical University, 2024, 45(2): 117-122. doi: 10.12259/j.issn.2095-610X.S20240216

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Evaluation of Cardiac Toxicity of Anthracyclines in Children with Acute Leukemia Based on Tei Index

doi: 10.12259/j.issn.2095-610X.S20240216

Xuemei CHEN¹,
Pin GUO²,
Liufang CHUAN³,
Zi WANG³,
Xuejiao LI^{2
,
,},
Wenji HE^{2
,
,}

1.
The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital Clinical Research Department of National Institute for Drug Clinical Trials （GCP office），Kunming Yunnan 650118
2.
Dept. of Ultrasound/Cardiac Function，Kunming Children’s Hospital，Kunming Medical University/Kunming Children’s Hospital，Kunming Yunnan 650228
3.
Dept. of Clinical Medicine，Affiliated Hospital of Yunnan University，Kunming Yunnan 650051，China

Received Date: 2023-03-29
Available Online: 2024-02-27
Publish Date: 2024-02-25

Abstract

Abstract

Objective To apply ultrasound to monitor cardiac function changes after anthracycline exposure in children with acute leukemia, in order to obtain the indicators of early changes in their cardiac function. Methods Children with acute leukemia from 2018 March to December 2020 in the Children’ s Hospital of Kunming Medical University were enrolled according to the inclusion and exclusion criteria, their routine cardiac ultrasound and tissue Doppler condition were recorded, and the changes in systolic function were evaluated by Tei index including TeiS, TeiRL, TeiM and TeiT. Results The mean values of LVEF in the normal and the experimental group were both above 60%. FS, SV, and EDV were all in the normal range. While common indicant, the index of TDI or Tei was not statistically significant（P>0.05）. The levels of TeiM, TeiRL and TieT in the groups that received a total dose of 200 mg/m² anthracyclines and 250 mg/m² were significantly different from that before treatment（P<0.05）. Conclusion Tei index can be utilized as a sensitive indicator for early changes in left and right heart function after children with acute leukemia are exposed to anthracyclines.
- Anthracyclines,
- Cardiac toxicity,
- Cardiac ultrasound,
- TeiS,
- TeiRL,
- TeiM,
- TeiT

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References(23)

References

[1]	吴剑秋,沈波,曹军宁,等. 中国蒽环类药物治疗淋巴瘤专家共识[J]. 癌症,2021,40(11):465-474.
[2]	Banke A,Fosbol E L,Moller J E,et al. Long-term effect of epirubicin on incidence of heart failure in women with breast cancer: insight from a randomized clinical trial[J]. Eur J Heart Fail,2018,20(10):1447-1453. doi: 10.1002/ejhf.1168
[3]	Lipshultz E R,Chow E J,Doody D R,et al. Cardiometabolic risk in childhood cancer survivors: a report from the children’s oncology group[J]. Cancer Epidemiol Biomarkers Prev,2022,31(3):536-542. doi: 10.1158/1055-9965.EPI-21-0360
[4]	Samosir S M,Utamayasa I,Andarsini M R,et al. Risk factors of daunorubicine induced early cardiotoxicity in childhood acute lymphoblastic leukemia: A retrospective study[J]. Asian Pac J Cancer Prev,2021,22(5):1407-1412. doi: 10.31557/APJCP.2021.22.5.1407
[5]	Bayram C,Cetin I,Tavil B,et al. Evaluation of cardiotoxicity by tissue doppler imaging in childhood leukemia survivors treated with low-dose anthracycline[J]. Pediatr Cardiol,2015,36(4):862-866. doi: 10.1007/s00246-015-1096-6
[6]	Leger K,Slone T,Lemler M,et al. Subclinical cardiotoxicity in childhood cancer survivors exposed to very low dose anthracycline therapy[J]. Pediatr Blood Cancer,2015,62(1):123-127. doi: 10.1002/pbc.25206
[7]	Amedro P,Vincenti M,Abassi H,et al. Use of speckle tracking echocardiography to detect late anthracycline-induced cardiotoxicity in childhood cancer: A prospective controlled cross-sectional study[J]. Int J Cardiol,2022,354(5):75-83.
[8]	Seara F,Kasai-Brunswick T H,Nascimento J,et al. Anthracycline-induced cardiotoxicity and cell senescence: New therapeutic option?[J]. Cell Mol Life Sci,2022,79(11):568. doi: 10.1007/s00018-022-04605-7
[9]	中国蒽环类药物治疗骨肉瘤专家共识[J]. 癌症, 2022, 41（8）: 368-384.
[10]	国家卫生健康委办公厅. 儿童急性早幼粒细胞白血病诊疗规范（2018年版）[S], 国卫办医函〔2018〕868号.
[11]	国家卫生健康委办公厅. 儿童急性淋巴细胞白血病诊疗规范（2018年版）[S], 国卫办医函〔2018〕868号.
[12]	Chang H M,Moudgil R,Scarabelli T,et al. Cardiovascular complications of cancer therapy: best practices in diagnosis,prevention,and management: Part 1[J]. J Am Coll Cardiol,2017,70(20):2536-2551. doi: 10.1016/j.jacc.2017.09.1096
[13]	Ganatra S,Nohria A,Shah S,et al. Upfront dexrazoxane for the reduction of anthracycline-induced cardiotoxicity in adults with preexisting cardiomyopathy and cancer: A consecutive case series[J]. Cardiooncology,2019,5(1):1-12.
[14]	邰宵辉,张玲芳,党春艳,等. 抗肿瘤药物致心脏损伤的药物防治进展[J]. 临床肿瘤学杂志,2023,28(1):70-76.
[15]	欧晓霞. 超声心动图E/Em、TDI-Tei指数及STI评价乳腺癌患者蒽环类化疗后早期心脏损伤[D]. 长沙: 湖南中医药大学, 2022.
[16]	Klaeboe L G,Edvardsen T. Echocardiographic assessment of left ventricular systolic function[J]. J Echocardiogr,2019,17(1):10-16. doi: 10.1007/s12574-018-0405-5
[17]	van den Bogaard V,van Luijk P,Hummel Y M,et al. Cardiac function after radiation therapy for breast cancer[J]. Int J Radiat Oncol Biol Phys,2019,104(2):392-400. doi: 10.1016/j.ijrobp.2019.02.003
[18]	罗银丽,陶方依,陈小维,等. 组织多普勒Tei指数评价蒽环类药物对乳腺癌患者左室功能的影响[J]. 温州医科大学学报,2022,52(1):47-50.
[19]	徐海燕,茅玲,刘海浪,等. 三维斑点追踪成像对乳腺癌病人蒽环类化疗早期心室收缩功能障碍的评价研究[J]. 中西医结合心脑血管病杂志,2023,21(3):515-519.
[20]	Tei C,Ling L H,Hodge D O,et al. New index of combined systolic and diastolic myocardial performance: A simple and reproducible measure of cardiac function-a study in normals and dilated cardiomyopathy[J]. J Cardiol,1995,26(6):357-366.
[21]	Kang Y,Scherrer-Crosbie M. Echocardiography imaging of cardiotoxicity[J]. Cardiol Clin,2019,37(4):419-427. doi: 10.1016/j.ccl.2019.07.006
[22]	邓曼,彭格红. 超声心动图用于蒽环类药物乳腺癌化疗后右心功能评估的研究进展[J]. 海南医学,2021,32(4):522-525.
[23]	韩若凌,尹笑笑,赵娜. Tei指数评价蒽环类药物对恶性肿瘤患儿的右心损害[J]. 中华医学超声杂志(电子版),2018,15(6):433-439.

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