Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province

Baining QIU; Yuebing WANG; Wu LONG; Sijie WEI; Rui WANG; Lin MA; Yanmei XI; Xue TANG; Puping LEI

doi:10.12259/j.issn.2095-610X.S20240821

Volume 45 Issue 8

Aug. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(8): 145-153

Baining QIU, Yuebing WANG, Wu LONG, Sijie WEI, Rui WANG, Lin MA, Yanmei XI, Xue TANG, Puping LEI. Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(8): 145-153. doi: 10.12259/j.issn.2095-610X.S20240821

Citation:

Baining QIU, Yuebing WANG, Wu LONG, Sijie WEI, Rui WANG, Lin MA, Yanmei XI, Xue TANG, Puping LEI. Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(8): 145-153. doi: 10.12259/j.issn.2095-610X.S20240821

Citation:

Baining QIU, Yuebing WANG, Wu LONG, Sijie WEI, Rui WANG, Lin MA, Yanmei XI, Xue TANG, Puping LEI. Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(8): 145-153. doi: 10.12259/j.issn.2095-610X.S20240821

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Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20240821

1.
Faculty of Forensic Medicine，Kunming Medical University，Kunming Yunnan 650500
2.
Yunnan Provincial Endemic Disease Control and Prevention Institute，Dali Yunnan 671000，China

Received Date: 2024-04-12
Available Online: 2024-07-05
Publish Date: 2024-08-25

Abstract

Abstract

Objective Compare the toxic effects of Amanita Manginiana from seven different regions in Yunnan Province on the livers and kidneys of mice. Methods The Kunming mice were randomly divided into 7 groups, each subgrouped into 6 h, 3 d, 7 d, and 14 d time points, with 5 mice in each time group. The experiment involved gastric lavage using Yunnan's Amanita Manginiana from 7 villages from different counties, with the control group （0 h） receiving an equivalent amount of saline lavage. Blood samples were taken from the eyes at different time points after each lavage to measure levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, and uric acid （UA） in the serum. The mice's liver and kidney weights were measured, their liver and kidney indices determined, and liver and kidney tissues were observed using HE staining. Results The Amanita Manginiana from Yuding Village, Mouding County （MDYD）, and Yongcui Village, Luquan County （LQYC）, caused acute damage to the livers and kidneys of mice. Within 6 hours of gavage, the mice's serum biochemical indicators began to rise, peaking on the 7th day, and started to decline by the 14th day, indicating a trend towards recovery of the damage （P < 0.05）. However, the Amanita Manginiana from Donghua Village, Tengchong City （TCDH）, and Yongcui Village, Luquan County （LQYC）, only damaged the livers of mice. Even after the 14th day, the levels of AST, ALT, and UA in the serum continued to rise, indicating a longer-lasting impact of the local Amanita Manginiana on the liver （P < 0.05）. The Amanita Manginiana from Moguang Village, Heqing County （HQMG）, Dean Village, Nanjian County （NJDA）, and Gaoping Village, Mouding County （MDGP）, caused damage to both the livers and kidneys of mice. After the 14th day, the levels of AST, ALT, and UA in the serum continued to increase （P < 0.05）, showing that the damage to the mice's liver and kidneys did not improve. Conclusion Amanita Manginiana from different villages in Yunnan Province contains varying levels of liver and kidney toxicity, posing a potential risk to the liver and kidneys. It is advisable to exercise caution when consuming Amanita Manginiana.
- Amanita manginiana,
- Hepatotoxicity,
- Renal toxicity,
- Yunnan

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