Volume 45 Issue 8
Aug.  2024
Turn off MathJax
Article Contents
Zhiye QI, Ying CHEN, Yan LI. Research Progress on Immunotoxicology of Pyrethroid Pesticides Exposures[J]. Journal of Kunming Medical University, 2024, 45(8): 154-160. doi: 10.12259/j.issn.2095-610X.S20240822
Citation: Zhiye QI, Ying CHEN, Yan LI. Research Progress on Immunotoxicology of Pyrethroid Pesticides Exposures[J]. Journal of Kunming Medical University, 2024, 45(8): 154-160. doi: 10.12259/j.issn.2095-610X.S20240822

Research Progress on Immunotoxicology of Pyrethroid Pesticides Exposures

doi: 10.12259/j.issn.2095-610X.S20240822
  • Received Date: 2024-02-20
    Available Online: 2024-07-08
  • Publish Date: 2024-08-25
  • Immune function is an important physiological function in the human body that plays a crucial role in maintaining human health. Pyrethroid pesticides (PYRs) and their metabolites can have immunotoxic effects on the body, increasing the risk of immune-related diseases. This review summarizes the effects of PYRs exposure on the body’ s immune organs, immune cells, and immune molecules, as well as the immunotoxic mechanisms, and provides a summary and outlook on the immunotoxicity caused by early-life PYRs exposure, offering new ideas and recommendations for human studies on the immunotoxicity of PYRs exposure.
  • loading
  • [1]
    Chrustek A,Holynska-Iwan I,Dziembowska I,et al. Current research on the safety of pyrethroids used as insecticides[J]. Medicina (Kaunas),2018,54(4):1-15.
    [2]
    Burns C J,Pastoor T P. Pyrethroid epidemiology: A quality-based review[J]. Crit Rev Toxicol,2018,48(4):297-311. doi: 10.1080/10408444.2017.1423463
    [3]
    Qi Z,Song X,Xiao X,et al. Effects of prenatal exposure to pyrethroid pesticides on neurodevelopment of 1-year- old children: A birth cohort study in China[J]. Ecotoxicol Environ Saf,2022,234(4):113384.
    [4]
    Chauhan R,Kumari B,Rana M K. Effect of fruit and vegetable processing on reduction of synthetic pyrethroid residues[J]. Rev Environ Contam Toxicol,2014,229(1):89-110.
    [5]
    Saillenfait A M,Ndiaye D,Sabate J P. Pyrethroids: Exposure and health effects-an update[J]. Int J Hyg Environ Health,2015,218(3): 281-292.
    [6]
    Kumar A,Sharma R,Rana D,et al. Protective effect of alpha-tocopherol in deltamethrin induced immunotoxicity[J]. Endocr Metab Immune Disord Drug Targets,2019,19(2):171-184. doi: 10.2174/1871530318666180801144822
    [7]
    Dawood M,Abdel-Kader M F,Moustafa E M,et al. Growth performance and hemato-immunological responses of Nile tilapia (Oreochromis niloticus) exposed to deltamethrin and fed immunobiotics[J]. Environ Sci Pollut Res Int,2020,27(11):11608-11617. doi: 10.1007/s11356-020-07775-8
    [8]
    Hussein M M,Ahmed M M. The Th1/Th2 paradigm in lambda cyhalothrin-induced spleen toxicity: The role of thymoquinone[J]. Environ Toxicol Pharmacol,2016,41(1):14-21.
    [9]
    Chauhan L K,Varshney M,Pandey V,et al. ROS-dependent genotoxicity,cell cycle perturbations and apoptosis in mouse bone marrow cells exposed to formulated mixture of cypermethrin and chlorpyrifos[J]. Mutagenesis,2016,31(6):635-642. doi: 10.1093/mutage/gew031
    [10]
    Prater M R,Gogal R J,Blaylock B L,et al. Single-dose topical exposure to the pyrethroid insecticide,permethrin in C57BL/6N mice: Effects on thymus and spleen[J]. Food Chem Toxicol,2002,40(12):1863-1873. doi: 10.1016/S0278-6915(02)00163-1
    [11]
    Kumar A,Sasmal D,Sharma N. Mechanism of deltamethrin induced thymic and splenic toxicity in mice and its protection by piperine and curcumin: In vivo study[J]. Drug Chem Toxicol,2018,41(1):33-41. doi: 10.1080/01480545.2017.1286352
    [12]
    Jin Y,Pan X,Fu Z. Exposure to bifenthrin causes immunotoxicity and oxidative stress in male mice[J]. Environ Toxicol,2014,29(9):991-999. doi: 10.1002/tox.21829
    [13]
    Aroonvilairat S,Tangjarukij C,Sornprachum T,et al. Effects of topical exposure to a mixture of chlorpyrifos,cypermethrin and captan on the hematological and immunological systems in male Wistar rats[J]. Environ Toxicol Pharmacol,2018,59(4):53-60.
    [14]
    Righi D A,Xavier F G,Palermo-Neto J. Effects of type II pyrethroid cyhalothrin on rat innate immunity: A flow cytometric study[J]. Int Immunopharmacol,2009,9(1):148-152.
    [15]
    Emara A M,Draz E I. Immunotoxicological study of one of the most common over-the-counter pyrethroid insecticide products in Egypt[J]. Inhal Toxicol,2007,19(12):997-1009.
    [16]
    Punareewattana K,Smith B J,Blaylock B L,et al. Topical permethrin exposure inhibits antibody production and macrophage function in C57Bl/6N mice[J]. Food Chem Toxicol,2001,39(2):133-139. doi: 10.1016/S0278-6915(00)00116-2
    [17]
    Dutta R,Das N. Immunomodulation of serum complement (C3) and macrophages by synthetic pyrethroid fenvalerate: In vitro study[J]. Toxicology,2011,285(3):126-132. doi: 10.1016/j.tox.2011.04.012
    [18]
    Zhang Y,Zhao M,Jin M,et al. Immunotoxicity of pyrethroid metabolites in an in vitro model[J]. Environ Toxicol Chem,2010,29(11):2505-2510.
    [19]
    Diel F,Horr B,Borck H,et al. Pyrethroids and piperonyl-butoxide affect human T-lymphocytes in vitro[J]. Toxicol Lett,1999,107(1):65-74.
    [20]
    Ramos-Chavez L A,Sordo M,Calderon-Aranda E,et al. A permethrin/allethrin mixture induces genotoxicity and cytotoxicity in human peripheral blood lymphocytes[J]. J Toxicol Environ Health A,2015,78(1):7-14. doi: 10.1080/15287394.2015.956025
    [21]
    Calderon-Segura M E,Gomez-Arroyo S,Cortes-Eslava J,et al. In vitro cytotoxicity and genotoxicity of Furia((R))180 SC (zeta-cypermethrin) and Bulldock 125((R))SC (beta-cyfluthrin) pyrethroid insecticides in human peripheral blood lymphocytes[J]. Toxicol Mech Methods,2018,28(4):268-278. doi: 10.1080/15376516.2017.1402977
    [22]
    Kumar A,Sasmal D,Bhaskar A,et al. Deltamethrin-induced oxidative stress and mitochondrial caspase-dependent signaling pathways in murine splenocytes[J]. Environ Toxicol,2016,31(7):808-819. doi: 10.1002/tox.22091
    [23]
    Kumar A,Gupta M,Sharma R,et al. Deltamethrin-induced immunotoxicity and its protection by Quercetin: An experimental study[J]. Endocr Metab Immune Disord Drug Targets,2020,20(1):67-76. doi: 10.2174/1871530319666190410144540
    [24]
    Joshi U,Pearson A,Evans J E,et al. A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness[J]. Brain Behav Immun,2019,81(10):545-559.
    [25]
    Hadnagy W,Leng G,Sugiri D,et al. Pyrethroids used indoors-immune status of humans exposed to pyrethroids following a pest control operation-a one year follow-up study[J]. Int J Hyg Environ Health,2003,206(2): 93-102.
    [26]
    El O E,Abdel-Hamid M A,Hamdy A M. Immunological and genotoxic effects of occupational exposure to alpha-cypermethrin pesticide[J]. Int J Occup Med Environ Health,2017,30(4):603-615.
    [27]
    Rehman H,Mohan A,Tabassum H,et al. Deltamethrin increases candida albicans infection susceptibility in mice[J]. Scand J Immunol,2011,73(5):459-464. doi: 10.1111/j.1365-3083.2011.02521.x
    [28]
    Zhang L,Zhao X,Yan S,et al. The immune responses of the Chinese rare minnow (Gobiocypris rarus) exposed to environmentally relevant concentrations of cypermethrin and subsequently infected by the bacteria Pseudomonas fluorescens[J]. Environ Pollut,2019,250(7):990-997.
    [29]
    Aouey B,Derbali M,Chtourou Y,et al. Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure[J]. Environ Sci Pollut Res Int,2017,24(6):5841-5856. doi: 10.1007/s11356-016-8323-4
    [30]
    Moustafa G G,Hussein M M. Lambda cyhalothrin toxicity induces alterations in lipogenic genes and inflammatory factors in rat liver[J]. Jpn J Vet Res,2016,64(1):25-38.
    [31]
    Shi W,Zhang D,Wang L,et al. Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro-inflammatory cytokines and Nrf2/Ho-1 pathway[J]. J Biochem Mol Toxicol,2019,33(10):e22386.
    [32]
    Fedeli D,Montani M,Carloni M,et al. Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide[J]. Biomarkers,2012,17(7):604-609. doi: 10.3109/1354750X.2012.706641
    [33]
    Costa C,Rapisarda V,Catania S,et al. Cytokine patterns in greenhouse workers occupationally exposed to alpha-cypermethrin: An observational study[J]. Environ Toxicol Pharmacol,2013,36(3):796-800. doi: 10.1016/j.etap.2013.07.004
    [34]
    Wang X,He B,Kong B,et al. beta-Cypermethrin and its metabolite 3-phenoxybenzoic acid exhibit immunotoxicity in murine macrophages[J]. Acta Biochim Biophys Sin (Shanghai),2017,49(12):1083-1091. doi: 10.1093/abbs/gmx111
    [35]
    Diel F,Horr B,Borck H,et al. Pyrethroid insecticides influence the signal transduction in T helper lymphocytes from atopic and nonatopic subjects[J]. Inflamm Res,2003,52(4):154-163. doi: 10.1007/s000110300066
    [36]
    Scatena R,Martorana G E,Bottoni P,et al. Mitochondrial dysfunction by synthetic ligands of peroxisome proliferator activated receptors (PPARs)[J]. IUBMB Life,2004,56(8):477-482. doi: 10.1080/15216540400008416
    [37]
    Elbanna R,Osman K A,Salama M S. Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats[J]. Toxicol Ind Health,2023,39(12):735-753. doi: 10.1177/07482337231209360
    [38]
    Kumar A,Sasmal D,Sharma N. Deltamethrin induced an apoptogenic signalling pathway in murine thymocytes : Exploring the molecular mechanism[J]. J Appl Toxicol,2014,34(12): 1303-1310.
    [39]
    Diel F,Horr B,Detscher M,et al. Pyrethroids and the synergist piperonyl-butoxide (PBO) affect T-cells and basophils[J]. Inflamm Res,1999,48(1):15-16.
    [40]
    Diel F,Detscher M,Schock B,et al. In vitro effects of the pyrethroid S-bioallethrin on lymphocytes and basophils from atopic and nonatopic subjects[J]. Allergy,1998,53(11):1052-1059. doi: 10.1111/j.1398-9995.1998.tb03814.x
    [41]
    Enan E,Pinkerton K E,Peake J,et al. Deltamethrin-induced thymus atrophy in male Balb/c mice[J]. Biochem Pharmacol,1996,51(4):447-454. doi: 10.1016/0006-2952(95)02200-7
    [42]
    王甜甜,陈淳媛,杨雷,等. Nrf2/HO-1信号轴在氧化应激性疾病中的机制[J]. 中南大学学报(医学版),2019,44(1):74-80. doi: 10.11817/j.issn.1672-7347.2019.01.012
    [43]
    Li B,Wang Y,Zhao H,et al. Oxidative stress is involved in the activation of NF-kappaB signal pathway and immune inflammatory response in grass carp gill induced by cypermethrin and/or sulfamethoxazole[J]. Environ Sci Pollut Res Int,2022,29(13):19594-19607. doi: 10.1007/s11356-021-17197-9
    [44]
    Dietert R R. Developmental immunotoxicology: Focus on health risks[J]. Chem Res Toxicol,2009,22(1):17-23. doi: 10.1021/tx800198m
    [45]
    Santoni G,Cantalamessa F,Cavagna R,et al. Cypermethrin-induced alteration of thymocyte distribution and functions in prenatally-exposed rats[J]. Toxicology,1998,125(1):67-78. doi: 10.1016/S0300-483X(97)00152-2
    [46]
    Hocine L,Merzouk H,Merzouk S A,et al. The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns[J]. Pestic Biochem Physiol,2016,134(11):49-54.
    [47]
    Jin Y,Zheng S,Fu Z. Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio)[J]. Fish Shellfish Immunol,2011,30(4-5):1049-1054. doi: 10.1016/j.fsi.2011.02.001
    [48]
    Neta G,Goldman L R,Barr D,et al. Fetal exposure to chlordane and permethrin mixtures in relation to inflammatory cytokines and birth outcomes[J]. Environ Sci Technol,2011,45(4):1680-1687. doi: 10.1021/es103417j
    [49]
    Michael B,Gregory A R,Aleksandr Y A,et al. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations,1990–2021: A systematic analysis for the Global Burden of Disease Study 2021[J]. The Lancet,2024,403(10440):2162-2203. doi: 10.1016/S0140-6736(24)00933-4
    [50]
    Kuper C F,van Bilsen J,Cnossen H,et al. Development of immune organs and functioning in humans and test animals: Implications for immune intervention studies[J]. Reprod Toxicol,2016,64(9):180-190.
    [51]
    Huang J,Eskenazi B,Bornman R,et al. Maternal peripartum serum DDT/E and urinary pyrethroid metabolite concentrations and child infections at 2 years in the VHEMBE birth cohort[J]. Environ Health Perspect,2018,126(6):67006. doi: 10.1289/EHP2657
  • Relative Articles

    [1] Jihong LIU, Zhiqiang MA, Lin WANG, Xiaoyan WANG, Weiguang TIAN, Baoping LI, Rui DONG, Yujia LV. Correlation Analysis of Immune Function of Tuberculosis Patients Infected with COVID-19. Journal of Kunming Medical University, 2024, 45(4): 157-162.  doi: 10.12259/j.issn.2095-610X.S20240423
    [2] Ying ZHANG, Fengxia YANG, Jing GUO, Qingling ZHANG. Effects of Systematic Psychological Intervention Based on S-ABC Framework on Perioperative Psychological Distress and Immune Function in Patients with Primary Liver Cancer. Journal of Kunming Medical University, 2023, 44(11): 170-174.  doi: 10.12259/j.issn.2095-610X.S20231126
    [3] Lin WANG, Lingjun SHEN, Haiwen LI, Xiaoyan WANG, Jianpeng GAO, Zhiqiang MA. Analysis of Nutritional Status and Immune Function of Tuberculosis Patients in Yunnan. Journal of Kunming Medical University, 2023, 44(1): 109-115.  doi: 10.12259/j.issn.2095-610X.S20230116
    [4] Ling HE, Zehao YU. Correlation between CD3+ HLA-DR Expression and Vita Level in Severe Mycoplasma Pneumoniae Pneumonia. Journal of Kunming Medical University, 2022, 43(5): 103-107.  doi: 10.12259/j.issn.2095-610X.S20220528
    [5] Nihong LU, Honglu LIU, Jiawei XIA, Yangjun CHEN, Linjun SHEN, Yongrui YANG, Jie LI. Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs. Journal of Kunming Medical University, 2022, 43(4): 50-54.  doi: 10.12259/j.issn.2095-610X.S20220410
    [6] Zhang-ping ZHOU, Xiao-qiong HE, Ling DUAN, Song TENG, Zhuo-xuan LIANG. Evaluation of Toxicology and Safety of Natural Active Compound Usenamine. Journal of Kunming Medical University, 2021, 42(6): 22-28.  doi: 10.12259/j.issn.2095-610X.S20210642
    [7] Ma Rui , Li Yan . Research Progress of Exposure to Pyrethroid Pesticides Impact on Reproductive System of Human and Physical Development of Infants. Journal of Kunming Medical University, 2019, 40(03): 126-130.
    [8] Tang Xue Mei , Li Yong , Li Ting Ting . A Study of Emergency Measures and Curative Effect of Respiratory Failure Caused by Organophosphorus Pesticide Poisoning. Journal of Kunming Medical University, 2018, 39(06): 71-75.
    [9] Sun Lin , Xiao Xia , Li Yan , Yang Si Wei , Xu Qing Hua , Ma Rui , Wu Jie , Zhang Chao , Guo Guang Ping . Pyrethroid Exposure and Related Factors among Pregnant Women in the First Trimester in Rural Yunnan Province, China. Journal of Kunming Medical University, 2018, 39(06): 39-43.
    [10] Xu Jing Xiao , Cheng Xin Yuan , Guo Shi Yu , Gu Li Hua , Wei Dan Xia , Yang Ren Hua . Effect of Qingre Runzao Oral Liquid on the Immune Function of BALB/C Mice. Journal of Kunming Medical University, 2017, 38(09): 11-14.
    [11] Yang Kai Yun . Effect of Single-port Video-assisted Thoracoscopic Surgery for Lung Cancer Radical Resection on Immune Function of Patients. Journal of Kunming Medical University,
    [12] He Yun Fa . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen. Journal of Kunming Medical University,
    [13] He Yun Fa , He Xiao Qiong , Jiang Zhong Yang , Wang Jing , Hu Song Shan , Shui Jing Lin . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen. Journal of Kunming Medical University, 2016, 37(11): 1-4.
    [14] Hong Xu Hua . Effects of Tuberculosis Drugs Combined with Rifapentine on the Immune Function, Inflammatory Factors, VEGF and MMP-9 of TB Patients. Journal of Kunming Medical University,
    [15] Li Bin . . Journal of Kunming Medical University,
    [16] Gu Xin . . Journal of Kunming Medical University,
    [17] . Correlation between Pain and Depression and Their Effect on Immune Function in Elderly Cancer Patients. Journal of Kunming Medical University,
    [18] Shen Li Da . . Journal of Kunming Medical University,
    [19] Zhu Xing Bao . . Journal of Kunming Medical University,
    [20] Zhang Yan Li . . Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)

    Article Metrics

    Article views (298) PDF downloads(11) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return