The Role of Macrophage Polarization in Thrombotic Diseases

Haopeng SHENTU; Jing YANG; Weiqing GE; Tao ZHOU; En SONG

doi:10.12259/j.issn.2095-610X.S20250101

Volume 46 Issue 1

Jan. 2025

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Haopeng SHENTU, Jing YANG, Weiqing GE, Tao ZHOU, En SONG. The Role of Macrophage Polarization in Thrombotic Diseases[J]. Journal of Kunming Medical University, 2025, 46(1): 1-8. doi: 10.12259/j.issn.2095-610X.S20250101

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Haopeng SHENTU, Jing YANG, Weiqing GE, Tao ZHOU, En SONG. The Role of Macrophage Polarization in Thrombotic Diseases[J]. Journal of Kunming Medical University, 2025, 46(1): 1-8. doi: 10.12259/j.issn.2095-610X.S20250101

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The Role of Macrophage Polarization in Thrombotic Diseases

doi: 10.12259/j.issn.2095-610X.S20250101

Department of Sports Medicine，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

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Corresponding author: 宋恩，男，博士，副主任医师，硕士研究生导师，昆明医科大学第一附属医院运动医学科医疗组长，主要从事脊柱创伤及退行性疾病的脊柱微创手术治疗，肩、膝关节病损的微创关节镜手术治疗。欧洲神经及脊柱外科协会(EANS)会员；国际神经内镜联盟(IFNE)会员；英国体育与运动医学学会杂志(BJSM)青年编委；中国医师协会骨科医师分会脊柱微创修复与重建学组委员；中国康复医学会骨伤康复专业委员会脊柱疼痛学组副主任委员；中国中西医结合骨伤科学会脊柱微创专家委员会委员；中国中西医结合骨伤科学会椎间盘退变与修复专家委员会委员；中国西部运动医学关节镜联盟会委员；云南省医学会运动医疗分会委员。荣获首届QCC国际大赛金奖。云南省“兴滇英才”青年人才、云南省医学“后备人才”。主持国家自然科学基金项目1项，云南省应用基础研究计划面上项目1项，云南省科技厅-昆明医科大学应用基础研究联合专项基金1项，发表论文9篇，主编专著1本，参编专著2本，执笔全国专家共识1篇，授权实用性新型专利4项。
Received Date: 2024-10-09
Available Online: 2024-12-25
Publish Date: 2025-01-17

Abstract

Abstract

Thrombotic diseases refer to a group of conditions characterized by abnormal blood coagulation within blood vessels, leading to the formation of blood clots and a series of clinical symptoms. This includes diseases such as deep vein thrombosis in the lower extremities, stroke, atherosclerosis, and diabetes. Thrombosis is a complex, progressive process that can be broadly summarized as the exposure of vascular endothelial damage, activation of the intrinsic coagulation system, platelet adhesion and aggregation, fibrin network formation, blood cell stasis. Macrophages play an important role in this process. They are involved in local inflammatory responses, regulating both the formation and resolution of thrombi. Macrophage polarization is a hot research topic in recent years, which mainly refers to the morphological and functional changes of macrophages in response different environmental stimuli. Macrophage polarization can be classified into classical （M1） and alternative （M2） types, as well as several specialized polarization states. The transition of macrophage polarization states plays an important role in immune responses, pathogen infections, tumor immunity, and autoimmune processes. This review discusses the regulatory relationship of macrophage polarization in thrombotic diseases, providing new directions for the treatment of these conditions.
- Thrombotic diseases,
- Deep vein thrombosis,
- Macrophages,
- Macrophage polarization

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References(49)

References

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