Research Progress on the Mechanisms of Action of Artemisinin and Its Derivatives in Cancer Therapy

Weixing ZENG; Yongwen HE

doi:10.12259/j.issn.2095-610X.S20250401

Volume 46 Issue 4

Apr. 2025

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Weixing ZENG, Yongwen HE. Research Progress on the Mechanisms of Action of Artemisinin and Its Derivatives in Cancer Therapy[J]. Journal of Kunming Medical University, 2025, 46(4): 1-7. doi: 10.12259/j.issn.2095-610X.S20250401

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Weixing ZENG, Yongwen HE. Research Progress on the Mechanisms of Action of Artemisinin and Its Derivatives in Cancer Therapy[J]. Journal of Kunming Medical University, 2025, 46(4): 1-7. doi: 10.12259/j.issn.2095-610X.S20250401

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Research Progress on the Mechanisms of Action of Artemisinin and Its Derivatives in Cancer Therapy

doi: 10.12259/j.issn.2095-610X.S20250401

Weixing ZENG,
Yongwen HE^,

Department of Oral and Maxillofacial Surgery，The Affiliated Stomatological Hospital of Kunming Medical University，Kunming Yunnan 650032，China

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Corresponding author: 何永文，医学博士，二级教授，博士生导师，教育部新世纪优秀人才支持计划入选者，云南省中青年学术和技术带头人、口腔颌面疾病防治省级创新团队带头人、口腔医学领军人才、万人计划名医专项人才，中华口腔医学会第一届、第二届及第三届口腔生物医学专业委员会委员，主要从事口腔肿瘤生物学研究。先后主持国家自然科学基金7项、云南省科技计划重点项目1项、应用基础研究基金2项。以第一作者或通讯作者在《Cell Research》《Cancer Research》等期刊上发表SCI收录论文20余篇，参编专著2本，获云南省科技进步二等奖2项、三等奖2项、卫生科技成果二等奖1项。
Received Date: 2024-11-19
Available Online: 2025-04-05
Publish Date: 2025-04-25

Abstract

Abstract

Due to their unique peroxide bridge structure, artemisinin and its derivatives have demonstrated the remarkable efficacy in treating severe malaria and exhibited the potent anticancer properties. These compounds interfere with the cancer cell growth through the multiple mechanisms, including the inhibition of cell proliferation, induction of various forms of cell death, cell cycle arrest, suppression of angiogenesis and modulation of the tumor microenvironment. Clinical trials have confirmed the significant anticancer activity of artemisinin-based compounds. This paper summarizes the recent advances and findings regarding the mechanisms of action of artemisinin and its derivatives as the potential anticancer agents, providing the valuable insights for future researches on the anticancer mechanisms of these compounds.
- Artemisinin,
- Artemisinin derivatives,
- Anticancer,
- Mechanisms of action

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References(54)

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